2. Metabolic Enzyme/Protease
  3. Drug Metabolite
  4. N-Deshydroxyethyl Dasatinib

N-Deshydroxyethyl Dasatinib  (Synonyms: N-Deshydroxyethyl BMS-354825)

Cat. No.: HY-107447 Purity: 98.58%
COA Handling Instructions

N-Deshydroxyethyl Dasatinib (N-Deshydroxyethyl BMS-354825) is a metabolite of Dasatinib, Dasatinib is a multi-kinase inhibitor that potently inhibits Bcr-Abl, Src family and platelet-derived growth factor receptor kinases. N-Deshydroxyethyl Dasatinib can be used in cancer and immune disease research.

For research use only. We do not sell to patients.

N-Deshydroxyethyl Dasatinib Chemical Structure

N-Deshydroxyethyl Dasatinib Chemical Structure

CAS No. : 910297-51-7

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Solution
10 mM * 1 mL in DMSO USD 275 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
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10 mg USD 380 In-stock
50 mg USD 980 In-stock
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Based on 1 publication(s) in Google Scholar

N-Deshydroxyethyl Dasatinib Related Antibodies

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Description

N-Deshydroxyethyl Dasatinib (N-Deshydroxyethyl BMS-354825) is a metabolite of Dasatinib, Dasatinib is a multi-kinase inhibitor that potently inhibits Bcr-Abl, Src family and platelet-derived growth factor receptor kinases. N-Deshydroxyethyl Dasatinib can be used in cancer and immune disease research[1][2].

In Vivo

1.19 Pharmacokinetic Parameters of N-Deshydroxyethyl Dasatinib in Wistar Rats[2].

Analyte Cmax (ng/mL) AUC0-t (h*ng/mL) AUC0-inf (h*ng/mL) Tmax (h) T1/2 (h) Kel (h-1)
N-Deshydroxyethyl Dasatinib 2.05 8.7 23.9 2.0 10.293 0.072

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

443.95

Appearance

Solid

Formula

C20H22ClN7OS
CAS No.
SMILES

O=C(C1=CN=C(NC2=NC(C)=NC(N3CCNCC3)=C2)S1)NC4=C(C)C=CC=C4Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 55 mg/mL (123.89 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2525 mL 11.2625 mL 22.5251 mL
5 mM 0.4505 mL 2.2525 mL 4.5050 mL
10 mM 0.2253 mL 1.1263 mL 2.2525 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.75 mg/mL (6.19 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.75 mg/mL (6.19 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.75 mg/mL (6.19 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 98.58%

COA (248 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References
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N-Deshydroxyethyl Dasatinib Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

N-Deshydroxyethyl Dasatinib910297-51-7N-Deshydroxyethyl BMS-354825Drug Metabolitecancerimmune diseaseInhibitorinhibitorinhibit

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