910297-51-7
Chemical Structure
N-Deshydroxyethyl Dasatinib
Synonym(s): N-Deshydroxyethyl BMS-354825
- CAS. Nr.: 910297-51-7
- Formula:C20H22ClN7OS
- Molecular Weight:443.95
IUPAC Name: N-(2-chloro-6-methylphenyl)-2-((2-methyl-6-(piperazin-1-yl)pyrimidin-4-yl)amino)thiazole-5-carboxamide
InChIKey: DOBZFFWLHXORTB-UHFFFAOYSA-N
SMILES: O=C(C1=CN=C(NC2=NC(C)=NC(N3CCNCC3)=C2)S1)NC4=C(C)C=CC=C4Cl
Biological Activity: N-Deshydroxyethyl Dasatinib (N-Deshydroxyethyl BMS-354825) is a metabolite of Dasatinib, Dasatinib is a multi-kinase inhibitor that potently inhibits Bcr-Abl, Src family and platelet-derived growth factor receptor kinases. N-Deshydroxyethyl Dasatinib can be used in cancer and immune disease research[1][2].
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N-Deshydroxyethyl Dasatinib | 97.19% | N-Deshydroxyethyl Dasatinib (N-Deshydroxyethyl BMS-354825) is a metabolite of Dasatinib, Dasatinib is a multi-kinase inhibitor that potently inhibits Bcr-Abl, Src family and platelet-derived growth factor receptor kinases. N-Deshydroxyethyl Dasatinib can be used in cancer and immune disease research. | ||||||||||||||||||||
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N-Deshydroxyethyl Dasatinib (Standard) | ≥98% | N-Deshydroxyethyl Dasatinib (Standard) is the analytical standard of N-Deshydroxyethyl Dasatinib. This product is intended for research and analytical applications. N-Deshydroxyethyl Dasatinib (N-Deshydroxyethyl BMS-354825) is a metabolite of Dasatinib, Dasatinib is a multi-kinase inhibitor that potently inhibits Bcr-Abl, Src family and platelet-derived growth factor receptor kinases. N-Deshydroxyethyl Dasatinib can be used in cancer and immune disease research. | ||||||||||||||||||||
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N-Deshydroxyethyl Dasatinib-d8 | N-Deshydroxyethyl Dasatinib-d8 is the deuterium labeled N-Deshydroxyethyl Dasatinib. N-Deshydroxyethyl Dasatinib (N-Deshydroxyethyl BMS-354825), the Dasatinib-based moiety, binds to IAP ligand via a linker to form SNIPER to degrade ABL. | |||||||||||||||||||||
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References
- [1]. Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666. [Content Brief]
- [2]. Thappali SR, et al. Simultaneous determination of methotrexate, dasatinib and its active metabolite N- deshydroxyethyl dasatinib in rat plasma by LC-MS/MS: method validation and application to pharmacokinetic study. Arzneimittelforschung. 2012 Dec;62(12):624-30. [Content Brief]
