2. PROTAC
  3. Ligands for Target Protein for PROTAC
  4. Dasatinib carbaldehyde

Dasatinib carbaldehyde  (Synonyms: BMS-354825 carbaldehyde; PROTAC ABL binding moiety 4)

Cat. No.: HY-111857 Purity: 98.04%
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Dasatinib carbaldehyde (BMS-354825 carbaldehyde), the Dasatinib (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER .

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Dasatinib carbaldehyde Chemical Structure

Dasatinib carbaldehyde Chemical Structure

CAS No. : 2112837-79-1

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Based on 1 publication(s) in Google Scholar

Dasatinib carbaldehyde Related Antibodies

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Description

Dasatinib carbaldehyde (BMS-354825 carbaldehyde), the Dasatinib (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER [1].

Molecular Weight

471.96

Formula

C21H22ClN7O2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC1=C(NC(C2=CN=C(NC3=CC(N4CCN(C=O)CC4)=NC(C)=N3)S2)=O)C(Cl)=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (70.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1188 mL 10.5941 mL 21.1882 mL
5 mM 0.4238 mL 2.1188 mL 4.2376 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.74%

COA (250 KB) HNMR (120 KB) RP-HPLC (138 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1188 mL 10.5941 mL 21.1882 mL 52.9706 mL
5 mM 0.4238 mL 2.1188 mL 4.2376 mL 10.5941 mL
10 mM 0.2119 mL 1.0594 mL 2.1188 mL 5.2971 mL
15 mM 0.1413 mL 0.7063 mL 1.4125 mL 3.5314 mL
20 mM 0.1059 mL 0.5297 mL 1.0594 mL 2.6485 mL
25 mM 0.0848 mL 0.4238 mL 0.8475 mL 2.1188 mL
30 mM 0.0706 mL 0.3531 mL 0.7063 mL 1.7657 mL
40 mM 0.0530 mL 0.2649 mL 0.5297 mL 1.3243 mL
50 mM 0.0424 mL 0.2119 mL 0.4238 mL 1.0594 mL
60 mM 0.0353 mL 0.1766 mL 0.3531 mL 0.8828 mL
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Dasatinib carbaldehyde Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dasatinib carbaldehyde2112837-79-1BMS-354825 carbaldehyde PROTAC ABL binding moiety 4PROTAC ABL binding moiety4PROTAC ABL binding moiety 4PROTAC ABL binding moiety-4Ligands for Target Protein for PROTACTarget Protein-binding MoietyInhibitorinhibitorinhibit

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