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Dasatinib hydrochloride

(Synonyms: BMS-354825 hydrochloride)
175 Cited Publications
Customer Review

Based on 175 publication(s) in Google Scholar

Dasatinib (BMS-354825) hydrochloride is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The Kis are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib hydrochloride inhibits Bcr-Abl and Src with IC50s of <1.0 nM and 0.5 nM, respectively. Dasatinib hydrochloride also induces apoptosis and autophagy.

For research use only. We do not sell to patients.

  • Purity: 99.31%
  • CAS No.: 854001-07-3
  • Formula: C22H27Cl2N7O2S
  • Molecular Weight:524.47
  • Storage:

    4°C, stored under nitrogen

    * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

  • Dasatinib hydrochloride Chemical Structure
    Dasatinib hydrochloride Chemical Structure
  • Experimental Validation Results for Dasatinib hydrochloride
  • Experimental Validation Results for Dasatinib hydrochloride
  • Experimental Validation Results for Dasatinib hydrochloride
  • Experimental Validation Results for Dasatinib hydrochloride
  • Experimental Validation Results for Dasatinib hydrochloride
  • Experimental Validation Results for Dasatinib hydrochloride
  • Experimental Validation Results for Dasatinib hydrochloride
  • Experimental Validation Results for Dasatinib hydrochloride
  • Experimental Validation Results for Dasatinib hydrochloride
  • Experimental Validation Results for Dasatinib hydrochloride
  • Experimental Validation Results for Dasatinib hydrochloride
  • Experimental Validation Results for Dasatinib hydrochloride
  • Experimental Validation Results for Dasatinib hydrochloride
  • Experimental Validation Results for Dasatinib hydrochloride
  • Experimental Validation Results for Dasatinib hydrochloride
  • Experimental Validation Results for Dasatinib hydrochloride
  • Experimental Validation Results for Dasatinib hydrochloride
  • Experimental Validation Results for Dasatinib hydrochloride
CAS No.: 854001-07-3
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  • Dasatinib hydrochloride Chemical Structure
    Dasatinib hydrochloride Chemical Structure
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    Dasatinib hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Aging. 2024 Apr;4(4):527-545. [Abstract]

    Customer Validation
     Dasatinib (100 nM; 24 h). mRNA relative expression of CDKN2A, IL-6 and IL-8 in si-FOXP1 COV434 treated with fisetin (F), quercetin (Q) and Dasatinib (D).

  • 1/16

    Dasatinib hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Aging. 2024 Apr;4(4):527-545. [Abstract]

    Customer Validation
     Dasatinib (100 nM; 24 h). Immunofluorescence staining of Ki67 upon administration of fisetin (F), quercetin (Q) and Dasatinib (D) in COV434 with knockdown of FOXP1.

  • 1/16

    Dasatinib hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Aging. 2024 Apr;4(4):527-545. [Abstract]

    Customer Validation
     Dasatinib (100 nM; 24 h). Immunofluorescence staining of γH2AX upon administration of fisetin (F), quercetin (Q) and dasatinib (D) in COV434 with knockdown of FOXP1.

  • 1/16

    Dasatinib hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Aging. 2024 Apr;4(4):527-545. [Abstract]

    Customer Validation
     Fisetin (10 μM, 24 h), Quercetin (10 μM, 24 h), or Dasatinib (100 nM, 24 h) delayed FOXP1 gene silencing-induced cellular senescence in COV434 cells.

  • 1/16

    Dasatinib hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2023 Mar;25(3):493-507. [Abstract]

    Customer Validation
     Dasatinib (50 nM; 24 or 48 h) significantly decreases MED8A and D458 cell migration.

  • 1/16

    Dasatinib hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2023 Mar;25(3):493-507. [Abstract]

    Customer Validation
     Dasatinib (50 nM;24 h-48 h) significantly decreases MED8A cell migration.

  • 1/16

    Dasatinib hydrochloride purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2023 Aug 29:14:1250383. [Abstract]

    Customer Validation
     Dasatinib hydrochloride (Dasatinib; 20 μM; 2 h) suppressed silica particle (SP)-induced cell death. Bone marrow-derived macrophages (BMDMs) were primed with lipopolysaccharide (LPS) (200 ng/mL) for 6 h. The cells were then treated with 20 µM of bosutinib, dasatinib, PD-161570, or PD-166285 and were stimulated or not stimulated with SPs (1,500 nm in diameter, 300 μg/mL) for 2 h. The cell death rate was determined by measuring lactate dehydrogenase (LDH) activity in the culture supernatant.

  • 1/16

    Dasatinib hydrochloride purchased from MedChemExpress. Usage Cited in: J Hematol Oncol. 2018 Aug 29;11(1):109. [Abstract]

    Customer Validation
     YSE450-R and EC109-R cells are treated with 200 nM BIBW 2992 alone or in combination with 100 nM Dasatinib for 48 h.

  • 1/16

    Dasatinib hydrochloride purchased from MedChemExpress. Usage Cited in: J Hematol Oncol. 2018 Aug 29;11(1):109. [Abstract]

    Customer Validation
     Resistant cells were treated with the indicated concentrations of afatinib in the presence or absence of 100 nM Dasatinib hydrochloride (Dasatinib) for 72 h, and CCK-8 assays were performed to assess cell viability.

  • 1/16

    Dasatinib hydrochloride purchased from MedChemExpress. Usage Cited in: J Hematol Oncol. 2018 Aug 29;11(1):109. [Abstract]

    Customer Validation
     Dasatinib hydrochloride (dasatinib; 15 mg/kg; daily for 21 days) showed anti-cancer activity in the xenograft growth of KYSE450-R and PDX03-R mice.

  • 1/16

    Dasatinib hydrochloride purchased from MedChemExpress. Usage Cited in: J Hematol Oncol. 2018 Aug 29;11(1):109. [Abstract]

    Customer Validation
     Dasatinib hydrochloride (dasatinib; 15 mg/kg; daily for 21 days) decreased the expression of phosphorylated S6 and ERK after afatinib combined with dasatinib treatment in xenografts growth of KYSE450-R and PDX03-R mice.

  • 1/16

    Dasatinib hydrochloride purchased from MedChemExpress. Usage Cited in: J Hematol Oncol. 2018 Aug 29;11(1):109. [Abstract]

    Customer Validation
     Dasatinib hydrochloride (Dasatinib; 20 μM; 2 h) suppressed silica particle (SP)-induced IL-1α and IL-1β release in BMDMs. Bone marrow-derived macrophages (BMDMs) were primed with lipopolysaccharide (LPS) (200 ng/mL) for 6 h. The cells were then treated with 20 µM of bosutinib, dasatinib, PD-161570, or PD-166285 and were stimulated or not stimulated with SPs (1,500 nm in diameter, 300 μg/mL) for 2 h. IL-1α and IL-1 beta (β) levels in the culture supernatants were measured using enzyme-linked immunosorbent assay (ELISA).

  • 1/16

    Dasatinib hydrochloride purchased from MedChemExpress. Usage Cited in: J Hematol Oncol. 2018 Aug 29;11(1):109. [Abstract]

    Customer Validation
     Dasatinib hydrochloride (Dasatinib; 20 μM; 4 h) suppressed SP-induced cell death accompanied by IL-1α and IL-1β release in phorbol 12-myristate 13-acetatetreated macrophage-like THP-1 cells. Phorbol 12-myristate 13-acetate-differentiated THP-1 cells were primed with LPS (50 ng/mL) for 16 h. The cells were then treated with dasatinib (20 µM) and were stimulated or not stimulated with SPs (1,500 nm in diameter, 500 μg/mL) for 4 h.

  • 1/16

    Dasatinib hydrochloride purchased from MedChemExpress. Usage Cited in: J Hematol Oncol. 2018 Aug 29;11(1):109. [Abstract]

    Customer Validation
     Dasatinib hydrochloride (Dasatinib; 20 μM; 2 h) suppressed silica particle (SP)-induced cell death. Bone marrow-derived macrophages (BMDMs) were primed with lipopolysaccharide (LPS) (200 ng/mL) for 6 h. The cells were then treated with 20 µM of bosutinib, dasatinib, PD-161570, or PD-166285 and were stimulated or not stimulated with SPs (1,500 nm in diameter, 300 μg/mL) for 2 h. The cell death rate was determined by measuring lactate dehydrogenase (LDH) activity in the culture supernatant.

  • 1/16

    Dasatinib hydrochloride purchased from MedChemExpress. Usage Cited in: Biol Pharm Bull. 2017;40(10):1747-1753. [Abstract]

    Customer Validation
     Synergistic Decrease Bcl-2 Expression by the Combination of SAHA with Dasatinib in MCF-7 Cells.

  • 1/16

    Dasatinib hydrochloride purchased from MedChemExpress. Usage Cited in: Chem Pharm Bull (Tokyo). 2017 Aug 1;65(8):768-775. [Abstract]

    Customer Validation
     Changes in Bcl-2 protein expression in MCF-7 cells after treatment with NSC 105014, Dasatinib or ZD1839 alone or in combination for 12 h. Expression of Bcl-2 protein is analyzed by western blotting analysis.

  • 1/16

    Dasatinib hydrochloride purchased from MedChemExpress. Usage Cited in: Kawasaki Medical Journal. 43(2)：63-78，2017.

    Customer Validation
     Western blot analysis of effects of Dasatinib (10 or 100nM) on c-Src, p-SrcY416, FAK and p-FAKY861 expression levels in KTC-1 cells and band intensities for p-SrcY416.

  • 1/16

    Dasatinib hydrochloride purchased from MedChemExpress. Usage Cited in: Leukemia. 2012 Oct;26(10):2233-44. [Abstract]

    Customer Validation
     Drug combination effect on phosphorylation of AKT. Expression of phospho-AKT and total AKT in MOLM13 cells treated for 15 minutes with DMSO vehicle, PKC412 (2.5 nM), Dasatinib (165 nM), or a combination of both. Protein lysates are prepared from MOLM13 cells, and are analyzed via immunoblotting with antibodies to phospho-AKT and total AKT.

  • Dasatinib hydrochloride