Dasatinib-d8
Based on 1 publication(s) in Google Scholar
Dasatinib-d8 (BMS-354825-d8) is a deuterium labeled Dasatinib. Dasatinib is a dual Bcr-Abl and Src family tyrosine kinase inhibitor.
For research use only. We do not sell to patients.
- Purity: 99.15%
- CAS No.: 1132093-70-9
- Formula: C22H18D8ClN7O2S
- Molecular Weight:496.05
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Dasatinib-d8
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1132093-70-9
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Unlabeled Cas 302962-49-8
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Appearance Solid
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Molecular Weight 496.05
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Formula C22H18D8ClN7O2S
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Color White to off-white
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SMILES
O=C(C1=CN=C(NC2=NC(C)=NC(N3C([2H])([2H])C([2H])([2H])N(CCO)C([2H])([2H])C3([2H])[2H])=C2)S1)NC4=C(C)C=CC=C4Cl
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Synonyms
BMS-354825-d8
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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J Chromatogr B Analyt Technol Biomed Life Sci
Development of a validated and sensitive ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method to simultaneous determination of crizotinib, alectinib and lorlatinib in human plasma. [Abstract]2025 Aug 28:1267:124770. PMID: 40902417
Solvent & Solubility
DMSO : 250 mg/mL (503.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (246 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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Handling Instructions (2659 KB)
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0159 mL | 10.0796 mL | 20.1593 mL | 50.3981 mL |
| 5 mM | 0.4032 mL | 2.0159 mL | 4.0319 mL | 10.0796 mL | |
| 10 mM | 0.2016 mL | 1.0080 mL | 2.0159 mL | 5.0398 mL | |
| 15 mM | 0.1344 mL | 0.6720 mL | 1.3440 mL | 3.3599 mL | |
| 20 mM | 0.1008 mL | 0.5040 mL | 1.0080 mL | 2.5199 mL | |
| 25 mM | 0.0806 mL | 0.4032 mL | 0.8064 mL | 2.0159 mL | |
| 30 mM | 0.0672 mL | 0.3360 mL | 0.6720 mL | 1.6799 mL | |
| 40 mM | 0.0504 mL | 0.2520 mL | 0.5040 mL | 1.2600 mL | |
| 50 mM | 0.0403 mL | 0.2016 mL | 0.4032 mL | 1.0080 mL | |
| 60 mM | 0.0336 mL | 0.1680 mL | 0.3360 mL | 0.8400 mL | |
| 80 mM | 0.0252 mL | 0.1260 mL | 0.2520 mL | 0.6300 mL | |
| 100 mM | 0.0202 mL | 0.1008 mL | 0.2016 mL | 0.5040 mL |
Dasatinib-d8 Related Classifications
HY-10181S Related Classifications
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