1. Cell Cycle/DNA Damage
    Epigenetics
  2. PARP

G007-LK 

Cat. No.: HY-12438 Purity: 99.24%
Data Sheet SDS Handling Instructions

G007-LK displays high selectivity toward tankyrases 1 and 2 with biochemical IC50 values of 46 nM and 25 nM, respectively, and a cellular IC50 value of 50 nM combined with an excellent pharmacokinetic profile in mice.

For research use only. We do not sell to patients.
G007-LK Chemical Structure

G007-LK Chemical Structure

CAS No. : 1380672-07-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO $140 In-stock
5 mg $120 In-stock
10 mg $190 In-stock
50 mg $750 In-stock
100 mg $970 In-stock
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

G007-LK displays high selectivity toward tankyrases 1 and 2 with biochemical IC50 values of 46 nM and 25 nM, respectively, and a cellular IC50 value of 50 nM combined with an excellent pharmacokinetic profile in mice. IC50 value: 46 nM/23 nM (TNKS1/TNKS2) [1] Target: Tankyrase inhibitor G007-LK shows a favorable combination of high target specificity to TNKS1/2, high potency, and in vitro as well as in vivo stability, leading to a good pharmacokinetic profile in mice. G007-LK shows a greater selectivity toward TNKS proteins. G007-LK extends the possibilities to selectively inhibit TNKS1/2 in vitro and in vivo. G007-LK provides an excellent small molecule for analyzing the functions of TNKS1/2 and Wnt/β-catenin signaling in cell biology, cancer, and disease models.

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 1.8869 mL 9.4347 mL 18.8693 mL
5 mM 0.3774 mL 1.8869 mL 3.7739 mL
10 mM 0.1887 mL 0.9435 mL 1.8869 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

529.96

Formula

C₂₅H₁₆ClN₇O₃S

CAS No.

1380672-07-0

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 30 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 99.24%

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Product Name:
G007-LK
Cat. No.:
HY-12438
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