EXQ-2d
EXQ-2d is the inhibitor for tankyrase and inhibits TNKS1 and TNKS2 with an IC50 of 48.8 nM and 13.8 nM (pIC50=7.31 and 7.86). EXQ-2d inhibits WNT/β-catenin signaling pathway with IC50 of 515 nM. EXQ-2d exhibits anti-proliferative activity in cancer cells COLO 320DM and RKO with GI50 of 4.9 μM and 77 μM.
For research use only. We do not sell to patients.
- Formula: C18H17N3O3
- Molecular Weight:323.35
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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TNKS2 13.8 nM (IC50) |
TNKS1 48.8 nM (IC50) |
Chemical Information
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Molecular Weight 323.35
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Formula C18H17N3O3
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SMILES
O=C1NC(C2=CC=C(C(C)(C)C)C=C2)=NC3=C([N+]([O-])=O)C=CC=C31
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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