1. Cell Cycle/DNA Damage
    Epigenetics
  2. PARP
  3. TC-E 5001

TC-E 5001 

Cat. No.: HY-108516
Handling Instructions

TC-E 5001 is an inhibitor of Wnt pathway that inhibits tankyrase 1/2 (TNKS1/2) via novel adenosine pocket binding, with Kds of 79 nM and 28 nM, respectively. TC-E 5001 also inhibits Axin2 and STF, with IC50s of 0.709 μM and 0.215 μM, respectively.

For research use only. We do not sell to patients.

TC-E 5001 Chemical Structure

TC-E 5001 Chemical Structure

CAS No. : 865565-29-3

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Description

TC-E 5001 is an inhibitor of Wnt pathway that inhibits tankyrase 1/2 (TNKS1/2) via novel adenosine pocket binding, with Kds of 79 nM and 28 nM, respectively. TC-E 5001 also inhibits Axin2 and STF, with IC50s of 0.709 μM and 0.215 μM, respectively[1][2].

IC50 & Target[1]

TNKS1

79 nM (Ki)

TNKS2

28 nM (Ki)

In Vitro

TC-E 5001 inhibits TNKS2, with an IC50 of 33 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

409.46

Formula

C₂₀H₁₉N₅O₃S

CAS No.
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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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TC-E 5001
Cat. No.:
HY-108516
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