TNKS1/2-IN-2
TNKS1/2-IN-2 (Compound 21) is a potent and selective tankyrases inhibitor. TNKS1/2-IN-2 exhibits IC50 values of 4 nM and 63 nM against TNK1 and TNK2 in the enzymatic assay, respectively. TNKS1/2-IN-2 inhibits proliferation of A549 and H292 cell lines with IC50 values of 39.5 nM and 12.8 nM, respectively. TNKS1/2-IN-2 can be used for the research of cancer.
For research use only. We do not sell to patients.
- CAS No.: 1498300-35-8
- Formula: C26H24F3N3O4
- Molecular Weight:499.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
IC50: 4 nM (TNK1); 63 nM (TNK2); 39.5 nM (A549 cell); 12.8 nM (H292 cell)[1].
Chemical Information
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CAS No. 1498300-35-8
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Molecular Weight 499.48
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Formula C26H24F3N3O4
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SMILES
O=C(N(C1=O)C[C@@H]2CC[C@H](CC2)C(O)=O)C(C(N1CC3=C(C(C(F)(F)F)=CC=C3)C#N)=CC=C4)=C4C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)