1498300-35-8
Chemical Structure
TNKS1/2-IN-2
- CAS No.: 1498300-35-8
- Formula:C26H24F3N3O4
- Molecular Weight:499.48
IUPAC Name: (1r,4r)-4-((1-(2-cyano-3-(trifluoromethyl)benzyl)-5-methyl-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)methyl)cyclohexane-1-carboxylic acid
InChIKey: QDVBJHFEZRTDHU-QAQDUYKDSA-N
SMILES: O=C(N(C1=O)C[C@@H]2CC[C@H](CC2)C(O)=O)C(C(N1CC3=C(C(C(F)(F)F)=CC=C3)C#N)=CC=C4)=C4C
Biological Activity:
TNKS1/2-IN-2 (Compound 21) is a potent and selective tankyrases inhibitor. TNKS1/2-IN-2 exhibits IC50 values of 4 nM and 63 nM against TNK1 and TNK2 in the enzymatic assay, respectively. TNKS1/2-IN-2 inhibits proliferation of A549 and H292 cell lines with IC50 values of 39.5 nM and 12.8 nM, respectively. TNKS1/2-IN-2 can be used for the research of cancer[1].
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TNKS1/2-IN-2 | TNKS1/2-IN-2 (Compound 21) is a potent and selective tankyrases inhibitor. TNKS1/2-IN-2 exhibits IC50 values of 4 nM and 63 nM against TNK1 and TNK2 in the enzymatic assay, respectively. TNKS1/2-IN-2 inhibits proliferation of A549 and H292 cell lines with IC50 values of 39.5 nM and 12.8 nM, respectively. TNKS1/2-IN-2 can be used for the research of cancer. |
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Keywords
