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United States

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製品番号: HY-155246

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PARP1-IN-15

PARP1-IN-15 (Compound 6) is a PARP1 inhibitor. PARP1-IN-15 inhibits tankyrase (TNKS) and facilitates DNA double-strand breaks damage. PARP1-IN-15 induces tumor cell apoptosis. PARP1-IN-15 has anti-cancer activity in triple-negative breast cancer (TNBC) cells and TNBC patient-derived organoids. PARP1-IN-15 can be used for research of TNBC with or without BRCA1 mutations.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₁₆H₁₂N₂O₂
分子量:264.28

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

PARP1-IN-15 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

PARP アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	GI₅₀	0.3 μM Compound: 63	Antiproliferative activity against human A2780 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human A2780 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 38784470]
A-431	GI₅₀	0.28 μM Compound: 63	Antiproliferative activity against human A-431 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human A-431 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 38784470]
BE(2)-C	GI₅₀	0.25 μM Compound: 63	Antiproliferative activity against human BE2C cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human BE2C cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 38784470]
DU-145	GI₅₀	0.35 μM Compound: 63	Antiproliferative activity against human DU-145 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human DU-145 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 38784470]
HT-29	GI₅₀	0.35 μM Compound: 63	Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 38784470]
MCF-10A	GI₅₀	0.38 μM Compound: 63	Cytotoxicity against human MCF-10A cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Cytotoxicity against human MCF-10A cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 38784470]
MCF7	GI₅₀	0.22 μM Compound: 63	Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 38784470]
MIA PaCa-2	GI₅₀	0.34 μM Compound: 63	Antiproliferative activity against human MIA PaCa-2 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human MIA PaCa-2 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 38784470]
NCI-H460	GI₅₀	0.37 μM Compound: 63	Antiproliferative activity against human NCI-H460 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human NCI-H460 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 38784470]
U-87MG ATCC	GI₅₀	0.48 μM Compound: 63	Antiproliferative activity against human U87 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay Antiproliferative activity against human U87 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay	[PMID: 38784470]

化学情報

分子量 264.28
分子式 C₁₆H₁₂N₂O₂
SMILES

O=C1NC(/C=C/C2=CC=C(O)C=C2)=NC3=CC=CC=C31
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (265 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Gong R, et al. Identification and evaluation of a novel PARP1 inhibitor for the treatment of triple-negative breast cancer. Chem Biol Interact. 2023 Sep 1;382:110567. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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