2. Apoptosis Epigenetics Cell Cycle/DNA Damage
  3. PARP Apoptosis
  4. PARP1-IN-15

PARP1-IN-15 (Compound 6) is a PARP1 inhibitor. PARP1-IN-15 inhibits tankyrase (TNKS) and facilitates DNA double-strand breaks damage. PARP1-IN-15 induces tumor cell apoptosis. PARP1-IN-15 has anti-cancer activity in triple-negative breast cancer (TNBC) cells and TNBC patient-derived organoids. PARP1-IN-15 can be used for research of TNBC with or without BRCA1 mutations.

For research use only. We do not sell to patients.

PARP1-IN-15

PARP1-IN-15 Chemical Structure

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PARP1-IN-15 Related Antibodies

Top Publications Citing Use of Products

View All PARP Isoform Specific Products:

View All Isoforms
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

  • Biological Activity

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Description

PARP1-IN-15 (Compound 6) is a PARP1 inhibitor. PARP1-IN-15 inhibits tankyrase (TNKS) and facilitates DNA double-strand breaks damage. PARP1-IN-15 induces tumor cell apoptosis. PARP1-IN-15 has anti-cancer activity in triple-negative breast cancer (TNBC) cells and TNBC patient-derived organoids. PARP1-IN-15 can be used for research of TNBC with or without BRCA1 mutations[1].

Cellular Effect
Cell Line Type Value Description References
A-431 GI50
0.28 μM
Compound: 63
Antiproliferative activity against human A-431 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human A-431 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 38784470]
A2780 GI50
0.3 μM
Compound: 63
Antiproliferative activity against human A2780 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human A2780 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 38784470]
BE(2)-C GI50
0.25 μM
Compound: 63
Antiproliferative activity against human BE2C cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human BE2C cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 38784470]
DU-145 GI50
0.35 μM
Compound: 63
Antiproliferative activity against human DU-145 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human DU-145 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 38784470]
HT-29 GI50
0.35 μM
Compound: 63
Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 38784470]
MCF-10A GI50
0.38 μM
Compound: 63
Cytotoxicity against human MCF-10A cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Cytotoxicity against human MCF-10A cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 38784470]
MCF7 GI50
0.22 μM
Compound: 63
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 38784470]
MIA PaCa-2 GI50
0.34 μM
Compound: 63
Antiproliferative activity against human MIA PaCa-2 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human MIA PaCa-2 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 38784470]
NCI-H460 GI50
0.37 μM
Compound: 63
Antiproliferative activity against human NCI-H460 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human NCI-H460 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 38784470]
U-87MG ATCC GI50
0.48 μM
Compound: 63
Antiproliferative activity against human U87 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human U87 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
[PMID: 38784470]
Molecular Weight

264.28

Formula

C16H12N2O2
SMILES

O=C1NC(/C=C/C2=CC=C(O)C=C2)=NC3=CC=CC=C31
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PARP1-IN-15 Related Classifications

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  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PARP1-IN-15PARPApoptosispoly ADP ribose polymerase cancertumorMDA-MB-436TNBCbreast cancerDNA damageorganoidInhibitorinhibitorinhibit

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