PARP1-IN-15
PARP1-IN-15 (Compound 6) is a PARP1 inhibitor. PARP1-IN-15 inhibits tankyrase (TNKS) and facilitates DNA double-strand breaks damage. PARP1-IN-15 induces tumor cell apoptosis. PARP1-IN-15 has anti-cancer activity in triple-negative breast cancer (TNBC) cells and TNBC patient-derived organoids. PARP1-IN-15 can be used for research of TNBC with or without BRCA1 mutations.
For research use only. We do not sell to patients.
- Formula: C16H12N2O2
- Molecular Weight:264.28
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A2780 | GI50 |
0.3 μM
Compound: 63
|
Antiproliferative activity against human A2780 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human A2780 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
|
[PMID: 38784470] |
| A-431 | GI50 |
0.28 μM
Compound: 63
|
Antiproliferative activity against human A-431 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human A-431 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
|
[PMID: 38784470] |
| BE(2)-C | GI50 |
0.25 μM
Compound: 63
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Antiproliferative activity against human BE2C cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human BE2C cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
|
[PMID: 38784470] |
| DU-145 | GI50 |
0.35 μM
Compound: 63
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Antiproliferative activity against human DU-145 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human DU-145 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
|
[PMID: 38784470] |
| HT-29 | GI50 |
0.35 μM
Compound: 63
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Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human HT-29 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
|
[PMID: 38784470] |
| MCF-10A | GI50 |
0.38 μM
Compound: 63
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Cytotoxicity against human MCF-10A cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Cytotoxicity against human MCF-10A cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
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[PMID: 38784470] |
| MCF7 | GI50 |
0.22 μM
Compound: 63
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Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
|
[PMID: 38784470] |
| MIA PaCa-2 | GI50 |
0.34 μM
Compound: 63
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Antiproliferative activity against human MIA PaCa-2 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human MIA PaCa-2 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
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[PMID: 38784470] |
| NCI-H460 | GI50 |
0.37 μM
Compound: 63
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Antiproliferative activity against human NCI-H460 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human NCI-H460 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
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[PMID: 38784470] |
| U-87MG ATCC | GI50 |
0.48 μM
Compound: 63
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Antiproliferative activity against human U87 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Antiproliferative activity against human U87 cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
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[PMID: 38784470] |
Chemical Information
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Molecular Weight 264.28
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Formula C16H12N2O2
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SMILES
O=C1NC(/C=C/C2=CC=C(O)C=C2)=NC3=CC=CC=C31
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PARP1-IN-15 Related Classifications
HY-155246 Related Classifications
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