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Cat. No.: HY-145111

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TNK2-IN-1

TNK2-IN-1 is a TNK2 inhibitor. TNK2-IN-1 has an IC₅₀ of 224 nM for TNK2. TNK2-IN-1 can be used for the research of cancer.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2574456-10-1
화학식: C₂₃H₂₄N₆O₂
분자량:416.48

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

TNK2-IN-1 Chemical Structure

CAS No.: 2574456-10-1

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

TNK2-IN-1 is a TNK2 inhibitor. TNK2-IN-1 has an IC₅₀ of 224 nM for TNK2. TNK2-IN-1 can be used for the research of cancer^[1].

IC₅₀ & Target

^[1]

TNK2

224 nM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
BaF3	IC₅₀	9.62 μM Compound: 39	Cytotoxicity against mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by cell titer glo luminescent cell viability assay Cytotoxicity against mouse BaF3 cells assessed as reduction in cell viability incubated for 72 hrs by cell titer glo luminescent cell viability assay	[PMID: 32739400]

In Vitro

TNK2-IN-1 (compound 21) has an IC₅₀ of 0.15 μM for cell viability of Ba/F3 cells expressing TNK2 D163E^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2574456-10-1
분자량 416.48
화학식 C₂₃H₂₄N₆O₂
SMILES

O=C1NC2=CN=C(NC3=C(OC)C=C(CCN(C4)C)C4=C3)N=C2C5=C(N1)C=C(C)C=C5
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li Z, et al. Discovery of a series of benzopyrimidodiazepinone TNK2 inhibitors via scaffold morphing. Bioorg Med Chem Lett. 2020 Oct 1;30(19):127456. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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