2. Cell Cycle/DNA Damage Epigenetics
  3. PARP
  4. TIQ-A

TIQ-A is a potent TNKS (poly-ART, PARP) inhibitor, with an IC50 of 24 nM for TNKS2. TIQ-A is a potential anti-ischemic agent.

For research use only. We do not sell to patients.

TIQ-A Chemical Structure

TIQ-A Chemical Structure

CAS No. : 420849-22-5

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 210 In-stock
Solution
10 mM * 1 mL in DMSO USD 210 In-stock
Solid
1 mg USD 95 In-stock
5 mg USD 200 In-stock
10 mg USD 350 In-stock
25 mg USD 650 In-stock
50 mg   Get quote  
100 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

TIQ-A Related Antibodies

Top Publications Citing Use of Products

View All PARP Isoform Specific Products:

View All Isoforms
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

TIQ-A is a potent TNKS (poly-ART, PARP) inhibitor, with an IC50 of 24 nM for TNKS2. TIQ-A is a potential anti-ischemic agent[1].

IC50 & Target

TNKS2

24 nM (IC50)

PARP2

210 nM (IC50)

PARP15

230 nM (IC50)

PARP10

>10 μM (IC50)

PARP14

>10 μM (IC50)

Molecular Weight

201.24

Formula

C11H7NOS
CAS No.
Appearance

Solid

Color

Light green to green

SMILES

O=C1NC2=C(C3=C1C=CC=C3)C=CS2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (621.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.9692 mL 24.8460 mL 49.6919 mL
5 mM 0.9938 mL 4.9692 mL 9.9384 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.9692 mL 24.8460 mL 49.6919 mL 124.2298 mL
5 mM 0.9938 mL 4.9692 mL 9.9384 mL 24.8460 mL
10 mM 0.4969 mL 2.4846 mL 4.9692 mL 12.4230 mL
15 mM 0.3313 mL 1.6564 mL 3.3128 mL 8.2820 mL
20 mM 0.2485 mL 1.2423 mL 2.4846 mL 6.2115 mL
25 mM 0.1988 mL 0.9938 mL 1.9877 mL 4.9692 mL
30 mM 0.1656 mL 0.8282 mL 1.6564 mL 4.1410 mL
40 mM 0.1242 mL 0.6211 mL 1.2423 mL 3.1057 mL
50 mM 0.0994 mL 0.4969 mL 0.9938 mL 2.4846 mL
60 mM 0.0828 mL 0.4141 mL 0.8282 mL 2.0705 mL
80 mM 0.0621 mL 0.3106 mL 0.6211 mL 1.5529 mL
100 mM 0.0497 mL 0.2485 mL 0.4969 mL 1.2423 mL
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TIQ-A Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TIQ-A420849-22-5PARPpoly ADP ribose polymeraseADP-ribosylationADP-ribosyltransferasetankyrasespoly-ARTInhibitorinhibitorinhibit

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