2. Cell Cycle/DNA Damage Epigenetics
  3. PARP
  4. OUL245

OUL245 is a 7-Hydroxy derivative, and a selectively PARP2 inhibitor (IC50=44 nM). OUL245 also inhibits other PARP and TNKS enzymes with IC50s of 2.9-8.8 μM.

For research use only. We do not sell to patients.

OUL245 Chemical Structure

OUL245 Chemical Structure

CAS No. : 1023814-45-0

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OUL245 Related Antibodies

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Description

OUL245 is a 7-Hydroxy derivative, and a selectively PARP2 inhibitor (IC50=44 nM). OUL245 also inhibits other PARP and TNKS enzymes with IC50s of 2.9-8.8 μM[1].

IC50 & Target[1]

PARP2

44 nM (IC50)

PARP-1

570 nM (IC50)

PARP3

8.8 μM (IC50)

PARP4

6.0 μM (IC50)

TNKS1

1.6 μM (IC50)

TNKS2

370 μM (IC50)

PARP10

2.9 μM (IC50)

PARP14

6.7 μM (IC50)

PARP15

2.0 μM (IC50)

In Vitro

OUL245 (1 μM; 10-12 d) unlike other derivatives, does not save cells overexpressing PARP10 from ADP ribosylation-dependent cell death[1].


Pharmacokinetic Analysis[1]

water solubility μg/mL GI Papp×10-6 cm/s (RM %) BBB Papp×10-6 cm/s (RM %) metabolic stablity % stab in human plasma stab. in MeOH stab in PBS pH 7.4
24.91 0.019 0.164 95.05 >24 >24 >24

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

OUL245 Related Antibodies
Molecular Weight

191.21

Formula

C8H5N3OS
CAS No.
SMILES

C1=CC2=C(C=C1O)SC3=NN=CN23
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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OUL245 Related Classifications

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× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OUL2451023814-45-0OUL 245OUL-245PARPpoly ADP ribose polymeraseInhibitorinhibitorinhibit

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HY-W294889
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