1. Cell Cycle/DNA Damage
    Epigenetics
    Apoptosis
  2. PARP
    Apoptosis
  3. PARP1/2/TNKS1/2-IN-1

PARP1/2/TNKS1/2-IN-1 

Cat. No.: HY-146336
Handling Instructions

PARP1/2/TNKS1/2-IN-1 (Compound I-9) is a dual PARP-1, PARP-2, TNKS1 and TNKS2 inhibitor with IC50 values of 0.25 nM, 1.2 nM, 13.5 nM and 4.15 nM against PARP-1, PARP-2, TNKS1 and TNKS2, respectively. PARP1/2/TNKS1/2-IN-1 exhibits favorable synergistic antitumor efficacy and induces apoptosis.

For research use only. We do not sell to patients.

PARP1/2/TNKS1/2-IN-1 Chemical Structure

PARP1/2/TNKS1/2-IN-1 Chemical Structure

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Description

PARP1/2/TNKS1/2-IN-1 (Compound I-9) is a dual PARP-1, PARP-2, TNKS1 and TNKS2 inhibitor with IC50 values of 0.25 nM, 1.2 nM, 13.5 nM and 4.15 nM against PARP-1, PARP-2, TNKS1 and TNKS2, respectively. PARP1/2/TNKS1/2-IN-1 exhibits favorable synergistic antitumor efficacy and induces apoptosis[1].

IC50 & Target

PARP-1

0.25 nM (IC50)

PARP-2

1.2 nM (IC50)

TNKS2

4.15 nM (IC50)

TNKS1

13.5 nM (IC50)

Molecular Weight

685.70

Formula

C38H32FN7O5

SMILES

COC1=CC=NC2=C1C=CC=C2NC(C3=CC=C(C=C3)NC(N4CCN(CC4)C(C5=CC(CC6=NNC(C7=CC=CC=C76)=O)=CC=C5F)=O)=O)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
PARP1/2/TNKS1/2-IN-1
Cat. No.:
HY-146336
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