ART-IN-1
Based on 1 Customer Validation
ART-IN-1 (compound 7) is a selective PARP inhibitor with IC50s of 19, 22, 2.4, >100, 1.1 µM for PARP2, TNKS2, PARP10, PARP14, PARP15, respectively.
For research use only. We do not sell to patients.
- Purity: 98.91%
- CAS No.: 2418014-98-7
- Formula: C14H13NO2S
- Molecular Weight:259.32
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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MCE Bioactive Compound Library
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Bioactive Compound Library
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High-Throughput Bioactive Compound Library
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Cell Cycle/DNA Damage Compound Library
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Epigenetics Compound Library
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Anti-Cancer Compound Library
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Anti-Aging Compound Library
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Anti-Breast Cancer Compound Library
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Anti-Pancreatic Cancer Compound Library
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Heterocyclic Compound Library
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Highly Selective Inhibitors Library
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Anti-Ovarian Cancer Compound Library
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Multi-Target Compound Library
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Bioactive Compound Library Max
HY-L181
Biological Activity
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PARP15 1.1 μM (IC50) |
PARP10 2.4 μM (IC50) |
PARP2 19 μM (IC50) |
TNKS2 22 μM (IC50) |
PARP14 >100 μM (IC50) |
Chemical Information
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CAS No. 2418014-98-7
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Appearance Solid
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Molecular Weight 259.32
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Formula C14H13NO2S
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Color White to off-white
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SMILES
CC(OC1=CC2=C(C(NC3=C2C=CS3)=O)C=C1)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (385.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (9.64 mM); Clear solution; Need ultrasonic
This protocol yields a clear solution of 2.5 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.5 mg/mL (9.64 mM); Clear solution; Need ultrasonic
This protocol yields a clear solution of 2.5 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.8562 mL | 19.2812 mL | 38.5624 mL | 96.4060 mL |
| 5 mM | 0.7712 mL | 3.8562 mL | 7.7125 mL | 19.2812 mL | |
| 10 mM | 0.3856 mL | 1.9281 mL | 3.8562 mL | 9.6406 mL | |
| 15 mM | 0.2571 mL | 1.2854 mL | 2.5708 mL | 6.4271 mL | |
| 20 mM | 0.1928 mL | 0.9641 mL | 1.9281 mL | 4.8203 mL | |
| 25 mM | 0.1542 mL | 0.7712 mL | 1.5425 mL | 3.8562 mL | |
| 30 mM | 0.1285 mL | 0.6427 mL | 1.2854 mL | 3.2135 mL | |
| 40 mM | 0.0964 mL | 0.4820 mL | 0.9641 mL | 2.4101 mL | |
| 50 mM | 0.0771 mL | 0.3856 mL | 0.7712 mL | 1.9281 mL | |
| 60 mM | 0.0643 mL | 0.3214 mL | 0.6427 mL | 1.6068 mL | |
| 80 mM | 0.0482 mL | 0.2410 mL | 0.4820 mL | 1.2051 mL | |
| 100 mM | 0.0386 mL | 0.1928 mL | 0.3856 mL | 0.9641 mL |
ART-IN-1 Related Classifications
HY-143338 Related Classifications
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