DESI2 - desumoylating isopeptidase 2 Gene

Also Known as DESI; DESI1; DeSI-2; PNAS-4; PPPDE1; CGI-146; FAM152A; C1orf121

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51029

About DESI2

Cytogenetic location: 1q44 Genomic coordinates (GRCh38): 1:244,653,126-244,709,033 (from NCBI)

This gene has 4 transcripts (splice variants), 208 orthologues and 1 paralogue. Broad expression in testis (RPKM 26.2), thyroid (RPKM 11.1) and 24 other tissues.

Summary

Enables Lys48-specific Deubiquitinase activity; Lys63-specific Deubiquitinase activity; and thiol-dependent Deubiquitinase. Predicted to be involved in protein deubiquitination. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

DESI2 Products (2)

mRNA Protein Name
NM_001297746.2 NP_001284675.1 deubiquitinase DESI2 isoform 2
NM_016076.5 NP_057160.2 deubiquitinase DESI2 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables K48-linked deubiquitinase activity IMP
IMP: Inferred from mutant phenotype
28483520 GOA
enables K63-linked deubiquitinase activity IMP
IMP: Inferred from mutant phenotype
28483520 GOA
enables cysteine-type deubiquitinase activity IDA
IDA: Inferred from direct assay
28483520 GOA
enables long-chain fatty acyl-CoA hydrolase activity IDA
IDA: Inferred from direct assay
35427157 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28483520 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DESI2 Protein Structure

Peptidase_C97

Peptidase_C97: PPPDE putative peptidase domain (7 - 149)

  • 0
  • 100
  • 194 a.a.
Protein Preferred Names Protein Names

deubiquitinase DESI2

  • PPPDE peptidase domain-containing protein 1

DESI2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DESI2 Q9BSY9 SEMA3G Homo sapiens Q9NS98
Validated Y2H
32296183
Intra
DESI2 Q9BSY9 SH3GLB1 Homo sapiens Q9Y371
Validated Y2H
32296183
Intra
DESI2 Q9BSY9 MYG1 Homo sapiens Q9HB07
Validated Y2H
32296183
Intra
DESI2 Q9BSY9 NFU1 Homo sapiens Q9UMS0
Validated Y2H
32296183
Intra
DESI2 Q9BSY9 THAP7 Homo sapiens Q9BT49
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Amyotrophic Lateral Sclerosis Type 5

  • Amyotrophic Lateral Sclerosis 5

  • Als5
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-180561 WWQ-03-012 98.04% Unkown
HY-RS03704 DESI1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03705 DESI2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta DESI2 VGNC VGNC:71695
Canis familiaris DESI2 VGNC VGNC:39907
Mus musculus DESI2 MGD MGI:1926075
Bos taurus DESI2 VGNC VGNC:28015
Rattus norvegicus DESI2 RGD RGD:1359392
Felis catus DESI2 VGNC VGNC:61452
Others DESI2 NCBI