SCAMP5 - secretory carrier membrane protein 5 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 192683

About SCAMP5

Cytogenetic location: 15q24.2 Genomic coordinates (GRCh38): 15:74,995,563-75,021,495 (from NCBI)

This gene has 18 transcripts (splice variants), 278 orthologues and 4 paralogues. Biased expression in brain (RPKM 81.6), duodenum (RPKM 16.5) and 6 other tissues.

Summary

Involved in positive regulation of cytokine production; regulation of vesicle-mediated transport; and response to endoplasmic reticulum stress. Located in Golgi apparatus; plasma membrane; and recycling endosome membrane. Is integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

SCAMP5 Products (3)

mRNA Protein Name
NM_001178111.2 NP_001171582.1 secretory carrier-associated membrane protein 5
NM_001178112.2 NP_001171583.1 secretory carrier-associated membrane protein 5
NM_138967.4 NP_620417.1 secretory carrier-associated membrane protein 5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15840657 GOA
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
19234194 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of endocytosis IDA
IDA: Inferred from direct assay
19240033 GOA
involved in positive regulation of calcium ion-dependent exocytosis IDA
IDA: Inferred from direct assay
19234194 GOA
involved in positive regulation of cytokine production IDA
IDA: Inferred from direct assay
19234194 GOA
involved in response to endoplasmic reticulum stress IDA
IDA: Inferred from direct assay
19240033 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi membrane IDA
IDA: Inferred from direct assay
19234194 GOA
located in membrane IDA
IDA: Inferred from direct assay
19234194 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
19234194 GOA
located in recycling endosome membrane IDA
IDA: Inferred from direct assay
15840657 GOA
located in trans-Golgi network membrane IDA
IDA: Inferred from direct assay
15840657 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCAMP5 Protein Structure

SCAMP

SCAMP: SCAMP family (5 - 180)

  • 0
  • 100
  • 200
  • 235 a.a.
Protein Preferred Names Protein Names

secretory carrier-associated membrane protein 5

  • hSCAMP5

SCAMP5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SCAMP5 Q8TAC9 SGPL1 Homo sapiens O95470
Y2H Array
32296183
Intra
SCAMP5 Q8TAC9 SGPL1 Homo sapiens O95470
Y2H Prey Pooling
32296183
Intra
SCAMP5 Q8TAC9 TLCD4 Homo sapiens Q96MV1
Y2H Prey Pooling
32296183
Intra
SCAMP5 Q8TAC9 TLCD4 Homo sapiens Q96MV1
Validated Y2H
32296183
Intra
SCAMP5 Q8TAC9 TLCD4 Homo sapiens Q96MV1
Y2H Array
32296183
Intra
SCAMP5 Q8TAC9 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
SCAMP5 Q8TAC9 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
SCAMP5 Q8TAC9 PITPNC1 Homo sapiens Q9UKF7-2
Validated Y2H
32296183
Intra
SCAMP5 Q8TAC9 MUC1 Homo sapiens P15941-11
Y2H Array
32296183
Intra
SCAMP5 Q8TAC9 MUC1 Homo sapiens P15941-11
Y2H Prey Pooling
32296183
Intra
SCAMP5 Q8TAC9 PIGP Homo sapiens P57054
Y2H Array
32296183
Intra
SCAMP5 Q8TAC9 PIGP Homo sapiens P57054
Y2H Prey Pooling
32296183
Intra
SCAMP5 Q8TAC9 SHISAL1 Homo sapiens Q3SXP7
Y2H Array
32296183
Intra
SCAMP5 Q8TAC9 SHISAL1 Homo sapiens Q3SXP7
Y2H Prey Pooling
32296183
Intra
SCAMP5 Q8TAC9 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
Intra
SCAMP5 Q8TAC9 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
Intra
SCAMP5 Q8TAC9 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra
SCAMP5 Q8TAC9 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra
SCAMP5 Q8TAC9 CERS4 Homo sapiens Q9HA82
Y2H Prey Pooling
32296183
Intra
SCAMP5 Q8TAC9 CERS4 Homo sapiens Q9HA82
Validated Y2H
32296183
Intra
SCAMP5 Q8TAC9 CERS4 Homo sapiens Q9HA82
Y2H Array
32296183
Cross
SCAMP5 Q8TAC9 Syt1 Mus musculus P46096
Pull Down
19234194
Cross
SCAMP5 Q8TAC9 Syt1 Mus musculus P46096
Anti Bait CoIP
19234194
Cross
SCAMP5 Q8TAC9 Syt2 Mus musculus P46097
Pull Down
19234194
Cross
SCAMP5 Q8TAC9 Syt2 Mus musculus P46097
Anti Bait CoIP
19234194
Intra
SCAMP5 Q8TAC9 TIMMDC1 Homo sapiens Q9NPL8
Y2H Array
32296183
Intra
SCAMP5 Q8TAC9 TIMMDC1 Homo sapiens Q9NPL8
Y2H Prey Pooling
32296183
Intra
SCAMP5 Q8TAC9 TIMMDC1 Homo sapiens Q9NPL8
Validated Y2H
32296183
Intra
SCAMP5 Q8TAC9 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra
SCAMP5 Q8TAC9 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra
SCAMP5 Q8TAC9 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra
SCAMP5 Q8TAC9 SH3GL1 Homo sapiens Q99961
Validated Y2H
32296183
Intra
SCAMP5 Q8TAC9 FATE1 Homo sapiens Q969F0
Validated Y2H
32296183
Intra
SCAMP5 Q8TAC9 FATE1 Homo sapiens Q969F0
Y2H Prey Pooling
32296183
Intra
SCAMP5 Q8TAC9 FATE1 Homo sapiens Q969F0
Y2H Array
32296183
Intra
SCAMP5 Q8TAC9 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Intra
SCAMP5 Q8TAC9 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra
SCAMP5 Q8TAC9 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Chromosome 15q24 Deletion Syndrome

  • 15q24 Microdeletion Syndrome

  • Del(15)(Q24)

  • Monosomy 15q24

  • 15q24 Microdeletion

  • 15q24 Deletion

  • Interstitial Deletion Of Chromosome 15q24
Atrial Septal Defect 1

  • ASD1

  • Atrial Heart Septal Defect 1

  • Asd
Autosomal Recessive Intellectual Developmental Disorder

  • Mental Retardation, Autosomal Recessive

  • Autosomal Recessive Mental Retardation

  • Autosomal Recessive Non-Syndromic Mental Retardation

  • Autosomal Recessive Non-Syndromic Intellectual Disability
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12482 SCAMP5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SCAMP5 RGD RGD:68356
Mus musculus SCAMP5 MGD MGI:1928948
Bos taurus SCAMP5 VGNC VGNC:34319
Felis catus SCAMP5 VGNC VGNC:64897
Canis familiaris SCAMP5 VGNC VGNC:45893
Macaca mulatta SCAMP5 VGNC VGNC:77136
Others SCAMP5 NCBI