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ARF6 - ADP ribosylation factor 6 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 382

About ARF6

Cytogenetic location: 14q21.3 Genomic coordinates (GRCh38): 14:49,893,082-49,897,054 (from NCBI)

This gene has 3 transcripts (splice variants), 197 orthologues and 30 paralogues. Ubiquitous expression in esophagus (RPKM 54.5), colon (RPKM 38.8) and 25 other tissues.

Summary

This gene encodes a member of the human ARF gene family, which is part of the Ras superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of Phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling. A pseudogene of this gene is located on chromosome 7. [provided by RefSeq, Jul 2008]

ARF6 Products (1)

mRNA	Protein	Name
NM_001663.4	NP_001654.1	ADP-ribosylation factor 6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables G protein activity	IDA IDA: Inferred from direct assay	32103017	GOA
enables GDP binding	IDA IDA: Inferred from direct assay	15126638	GOA
enables GTP binding	IDA IDA: Inferred from direct assay	10391955	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9312003	GOA
enables signaling adaptor activity	IDA IDA: Inferred from direct assay	37461827	GOA
enables thioesterase binding	IPI IPI: Inferred from physical interaction	15509780	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cortical actin cytoskeleton organization	IDA IDA: Inferred from direct assay	10036235	GOA
involved in cortical actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	10913182	GOA
involved in endocytic recycling	IDA IDA: Inferred from direct assay	10036235	GOA
involved in positive regulation of actin filament polymerization	IMP IMP: Inferred from mutant phenotype	10036235	GOA
involved in positive regulation of mitotic cytokinetic process	IMP IMP: Inferred from mutant phenotype	17628206	GOA
involved in positive regulation of neuron projection development	IDA IDA: Inferred from direct assay	36250347	GOA
involved in positive regulation of protein secretion	IMP IMP: Inferred from mutant phenotype	27044754	GOA
involved in protein localization to cleavage furrow	IMP IMP: Inferred from mutant phenotype	16148947	GOA
involved in protein localization to endosome	IMP IMP: Inferred from mutant phenotype	21951725	GOA
involved in protein localization to plasma membrane	IDA IDA: Inferred from direct assay	37461827	GOA
involved in regulation of Rac protein signal transduction	IDA IDA: Inferred from direct assay	10036235	GOA
involved in regulation of filopodium assembly	IDA IDA: Inferred from direct assay	14978216	GOA
involved in ruffle assembly	IDA IDA: Inferred from direct assay	10036235	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Flemming body	IDA IDA: Inferred from direct assay	23603394	GOA
located in cell cortex	IDA IDA: Inferred from direct assay	10913182	GOA
located in cleavage furrow	IDA IDA: Inferred from direct assay	23603394	GOA
is active in cleavage furrow	IMP IMP: Inferred from mutant phenotype	16148947	GOA
is active in cytosol	IDA IDA: Inferred from direct assay	32103017	GOA
located in cytosol	IDA IDA: Inferred from direct assay	10391955	GOA
located in endocytic vesicle	IDA IDA: Inferred from direct assay	19948740	GOA
located in endosome	IDA IDA: Inferred from direct assay	20682791	GOA
located in filopodium membrane	IDA IDA: Inferred from direct assay	14978216	GOA
located in membrane	IDA IDA: Inferred from direct assay	10391955	GOA
is active in midbody	IMP IMP: Inferred from mutant phenotype	16148947	GOA
is active in plasma membrane	IDA IDA: Inferred from direct assay	32103017	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	10036235	GOA
located in recycling endosome membrane	IDA IDA: Inferred from direct assay	10036235	GOA
located in ruffle	IDA IDA: Inferred from direct assay	9312003	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARF6 Protein Structure

Arf

0
100
175 a.a.

Protein Preferred Names	Protein Names
ADP-ribosylation factor 6

ARF6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ARF6	P62330	SPAG9	Homo sapiens	O60271	SPR	19644450
Intra	ARF6	P62330	SPAG9	Homo sapiens	O60271	Solution Sedimentation	19644450
Intra	ARF6	P62330	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	ARF6	P62330	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	ARF6	P62330	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Cross	ARF6	P62330	P0DTD1-PRO_0000449632	SARS-CoV-2	P0DTD1-PRO_0000449632	Y2H Array	36217030
Intra	ARF6	P62330	KIF23	Homo sapiens	Q02241	Y2H	22580824
Intra	ARF6	P62330	KIF23	Homo sapiens	Q02241	Pull Down	22580824
Intra	ARF6	P62330	GGA3	Homo sapiens	Q9NZ52	Pull Down	24056087
Intra	ARF6	P62330	ARFIP2	Homo sapiens	P53365	Y2H	9312003
Intra	ARF6	P62330	ARFIP2	Homo sapiens	P53365	Beta Galactosidase	9312003
Intra	ARF6	P62330	APBB1	Homo sapiens	O00213	Pull Down	24056087
Intra	ARF6	P62330	APBB1	Homo sapiens	O00213	Anti Tag CoIP	24056087
Intra	ARF6	P62330	ATP6V1C1	Homo sapiens	P21283	Anti Bait CoIP	16415858

Cross: Cross-species interaction Intra: Intraspecies interaction

ARF6 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810848	ARF6 Antibody	WB, IHC-P, ICC/IF	Human, Mouse, Rat
HY-P83271	ARF6 Antibody (YA3016)	WB, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Cholera	Vibrio Cholerae Infection Cholera - Vibrio Cholerae Cholera Due To Vibrio Cholerae Vibrio Cholerae Cholera Syndrome Asiatic Cholera Epidemic Cholera
Deafness, Onychodystrophy, Osteodystrophy, Mental Retardation, And Seizures Syndrome	Door Syndrome Doors Syndrome Digitorenocerebral Syndrome Autosomal Recessive Deafness-Onychodystrophy Syndrome Deafness-Onychoosteodystrophy-Intellectual Disability Syndrome DOORS Drc Syndrome Eronen Syndrome Deafness-Onychodystrophy-Osteodystrophy-Intellectual Disability Syndrome Brachydactyly Due To Absence Of Distal Phalanges Deafness-Onychodystrophy-Osteodystrophy-Intellectual Disability-Seizures Syndrome Deafness, Onychodystrophy, Osteodystrophy, And Mental Retardation Syndrome Deafness-Oncychodystrophy-Osteodystrophy-Intellectual Disability Syndrome Autosomal Recessive Hearing Loss-Onychodystrophy Syndrome Hearing Loss-Onychodystrophy-Osteodystrophy-Intellectual Disability Syndrome Hearing Loss-Onychodystrophy-Osteodystrophy-Intellectual Disability-Seizures Syndrome Hearing Loss-Onychoosteodystrophy-Intellectual Disability Syndrome Deafness, Onychodystrophy, Osteodystrophy, Intellectual Disability, And Seizures Syndrome Deafness, Congenital Onychodystrophy, Recessive Form Deafness, Onychodystrophy, Osteodystrophy, Mental Retardation Syndrome
Warburg Micro Syndrome 1	Warburg Micro Syndrome Micro Syndrome Warbm WARBM1 Warburg Sjo Fledelius Syndrome Warburg-Sjo-Fledelius Syndrome Micro Syndrome 1 Microcephaly, Microcornea, Congenital Cataract, Intellectual Disability, Optic Atrophy And Hypogenitalism
Non-Syndromic X-Linked Intellectual Disability	X-Linked Non-Syndromic Intellectual Disability Non-Specific X-Linked Mental Retardation X-Linked Non-Specific Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112473	Grassofermata	Inhibitor	99.10%	Unkown
HY-139950	Rasarfin	Inhibitor	99.57%	Unkown
HY-RS00898	ARF6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-P10178	Myristoylated ARF6 (2-13)	Inhibitor	/	Unkown
HY-P10179	ARF6 (2-13)		/	Unkown
HY-RS18229	Arf6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24708	Arf6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ARF6	VGNC	VGNC:26061
Macaca mulatta	ARF6	VGNC	VGNC:84306
Mus musculus	ARF6	MGD	MGI:99435
Canis familiaris	ARF6	VGNC	VGNC:38031
Felis catus	ARF6	VGNC	VGNC:68044
Rattus norvegicus	ARF6	RGD	RGD:621279
Others	ARF6	NCBI