KIF23 - kinesin family member 23 Gene

Also Known as CHO1; KNSL5; MKLP1; CDAN3A; MKLP-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9493

About KIF23

Cytogenetic location: 15q23 Genomic coordinates (GRCh38): 15:69,414,349-69,448,427 (from NCBI)

This gene has 16 transcripts (splice variants), 268 orthologues, 41 paralogues and is associated with 2 phenotypes. Broad expression in bone marrow (RPKM 9.3), testis (RPKM 8.0) and 17 other tissues.

Summary

The protein encoded by this gene is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013]

KIF23 Products (5)

mRNA	Protein	Name
NM_001281301.2	NP_001268230.1	kinesin-like protein KIF23 isoform 3
NM_001367804.2	NP_001354733.1	kinesin-like protein KIF23 isoform 4
NM_001367805.3	NP_001354734.1	kinesin-like protein KIF23 isoform 5
NM_004856.7	NP_004847.2	kinesin-like protein KIF23 isoform 2
NM_138555.4	NP_612565.1	kinesin-like protein KIF23 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables microtubule binding	IDA IDA: Inferred from direct assay	11782313	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11782313	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mitotic cytokinesis	IMP IMP: Inferred from mutant phenotype	15843429	GOA
involved in mitotic spindle midzone assembly	IMP IMP: Inferred from mutant phenotype	16103226	GOA
involved in positive regulation of cytokinesis	IMP IMP: Inferred from mutant phenotype	16103226	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of centralspindlin complex	IDA IDA: Inferred from direct assay	11782313	GOA
located in centrosome	IDA IDA: Inferred from direct assay	20186884	GOA
located in midbody	IDA IDA: Inferred from direct assay	11782313	GOA
located in mitotic spindle	IDA IDA: Inferred from direct assay	16236794	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11782313	GOA
located in spindle	IDA IDA: Inferred from direct assay	15197175	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KIF23 Protein Structure

Kinesin

0
200
400
600
800
960 a.a.

Protein Preferred Names	Protein Names
kinesin-like protein KIF23	kinesin-like 5 (mitotic kinesin-like protein 1)

KIF23 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KIF23	Q02241	BIRC6	Homo sapiens	Q9NR09	IF	18329369
Intra	KIF23	Q02241	BIRC6	Homo sapiens	Q9NR09	Anti Bait CoIP	18329369
Intra	KIF23	Q02241	BIRC6	Homo sapiens	Q9NR09	Anti Tag CoIP	18329369
Intra	KIF23	Q02241	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
Intra	KIF23	Q02241	YWHAZ	Homo sapiens	P63104	Pull Down	20451386
Intra	KIF23	Q02241	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	26496610
Intra	KIF23	Q02241	YWHAG	Homo sapiens	P61981	CoIP	15324660
Intra	KIF23	Q02241	ARF6	Homo sapiens	P62330	Y2H	22580824
Intra	KIF23	Q02241	ARF6	Homo sapiens	P62330	IF	22522702
Intra	KIF23	Q02241	ARF6	Homo sapiens	P62330	Pull Down	22580824
Intra	KIF23	Q02241	RACGAP1	Homo sapiens	Q9H0H5	Density Sedimentation	11782313
Intra	KIF23	Q02241	RACGAP1	Homo sapiens	Q9H0H5	Anti Tag CoIP	26496610
Intra	KIF23	Q02241	RACGAP1	Homo sapiens	Q9H0H5	Y2H	22580824
Intra	KIF23	Q02241	RACGAP1	Homo sapiens	Q9H0H5	Anti Tag CoIP	35271311
Intra	KIF23	Q02241	RACGAP1	Homo sapiens	Q9H0H5	Anti Bait CoIP	18201571
Intra	KIF23	Q02241	RACGAP1	Homo sapiens	Q9H0H5	Anti Bait CoIP	11782313
Intra	KIF23	Q02241	RACGAP1	Homo sapiens	Q9H0H5	Pull Down	22580824
Cross	KIF23	Q02241	Arf6	Mus musculus	P62331	SAXS	22522702
Cross	KIF23	Q02241	Arf6	Mus musculus	P62331	Pull Down	22522702

Cross: Cross-species interaction Intra: Intraspecies interaction

KIF23 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810722	MKLP1 Antibody (YA9967)	WB, ICC/IF	Human, Mouse, Rat
HY-P83488	MKLP1 Antibody (YA3233)	WB, ICC/IF	Human
HY-P83488A	MKLP1 Antibody (YA3233)(PBS only)	WB, ICC/IF	Human

Related Diseases

Diseases	Alias
Anemia, Congenital Dyserythropoietic, Type Iiia	Congenital Dyserythropoietic Anemia, Type Iii Cdan3 Congenital Dyserythropoietic Anemia Type Iii Cda Iii Congenital Dyserythropoietic Anemia Type 3 CDAN3A Dyserythropoietic Anemia, Congenital, Type Iiia Cda, Type Iiia Anemia, Congenital Dyserythropoietic, Type Iii Anemia With Multinucleated Erythroblasts Cda Type 3 Cda Type Iii Dyserythropoietic Anemia, Congenital Type 3 Cda, Type Iii Erythroreticulosis, Hereditary Benign Anaemia With Multinucleated Erythroblasts Congenital Dyserythropoietic Anaemia Type 3 Congenital Dyserythropoietic Anaemia Type Iii Hereditary Benign Erythroreticulosis Anemia, Congenital Dyserythropoietic, 3a Anemia With Multinucleated Erythroblasts Erythroreticulosis, Hereditary Benign
Anemia, Congenital Dyserythropoietic, Type Ia	Congenital Dyserythropoietic Anemia Type I Cda I CDAN1A Congenital Dyserythropoietic Anemia Type 1 Congenital Dyserythropoietic Anemia Type Ia Congenital Dyserythropoietic Anemia, Type I Anemia, Congenital Dyserythropoietic, Type I Cda Type 1 Cda Type I Cda Ia Dyserythropoietic Anemia, Congenital Type 1 Anemia, Congenital Dyserythropoietic, Type 1a Dyserythropoietic Anemia, Congenital, Type Ia Cda, Type Ia Congenital Dyserythropoietic Anaemia Type 1 Congenital Dyserythropoietic Anaemia Type I Anemia, Dyserythropoietic, Congenital Type 1 Type I Congenital Dyserythropoietic Anemia Anemia, Congenital Dyserythropoietic, 1a Anemia, Dyserythropoietic, Congenital, Type Ia
Anemia, Congenital Dyserythropoietic, Type Iv	CDAN4 Congenital Dyserythropoietic Anemia Type Iv Congenital Dyserythropoietic Anemia Type 4 Cda Iv Cda Due To Klf1 Mutation Cda Type 4 Cda Type Iv Congenital Dyserythropoietic Anemia Due To Klf1 Mutation Cda, Type Iv Dyserythropoietic Anemia, Congenital, Type Iv Congenital Dyserythropoietic Anaemia Due To Klf1 Mutation Congenital Dyserythropoietic Anaemia Type 4 Congenital Dyserythropoietic Anaemia Type Iv Anemia, Congenital Dyserythropoietic, 4 Anemia, Dyserythropoietic Congenital, Type Iv Anemia, Dyserythropoietic, Congenital, Type Iv
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Anemia, Congenital Dyserythropoietic, Type Ib	CDAN1B Congenital Dyserythropoietic Anemia Type Ib Cda, Type Ib Congenital Dyserythropoietic Anemia Type Type 1b Dyserythropoietic Anemia, Congenital, Type Ib Anemia, Congenital Dyserythropoietic, 1b Cda Ib Anemia, Dyserythropoietic, Congenital Anemia, Dyserythropoietic, Congenital, Type Ib
Anemia, Congenital Dyserythropoietic, Type Ii	Congenital Dyserythropoietic Anemia Type Ii CDAN2 Cda Ii Hereditary Erythroblastic Multinuclearity With Positive Acidified-Serum Test Cda Type Ii Congenital Dyserythropoietic Anemia Type 2 Hereditary Erythroblastic Multinuclearity With A Positive Acidified-Serum Test Sec23b-Cdg Congenital Dyserythropoietic Anemia, Type Ii Dyserythropoietic Anemia, Hempas Type Hempas Cda Type 2 Dyserythropoietic Anemia, Congenital, Type Ii Cda, Type Ii Congenital Dyserythropoietic Anaemia Type 2 Congenital Dyserythropoietic Anaemia Type Ii Anemia, Dyserythropoietic, Congenital Type 2 Hempas Anemia Dyserythropoietic Anemia, Congenital Type 2 Anemia, Congenital Dyserythropoietic, 2 Dyserythropoietic Anemia Hempas Type Anemia, Dyserythropoietic Congenital, Type Ii Anemia, Dyserythropoietic, Congenital, Type Ii
Congenital Dyserythropoietic Anemia	Congenital Dyshaematopoietic Anaemia Dyserythropoietic Anemia, Congenital Cda Anemia, Dyserythropoietic, Congenital Anemia Dyserythropoietic Congenital Cda - [Congenital Dyserythropoietic Anaemia] Dyserythropoietic Dyshaematopoietic Congenital Anaemia Dyshaematopoietic Anaemia Dyserythropoietic Anaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07277	KIF23 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KIF23	MGD	MGI:1919069
Rattus norvegicus	KIF23	RGD	RGD:1308596
Canis familiaris	KIF23	VGNC	VGNC:59116
Macaca mulatta	KIF23	VGNC	VGNC:84364
Bos taurus	KIF23	VGNC	VGNC:55119
Felis catus	KIF23	VGNC	VGNC:80939
Others	KIF23	NCBI