MKLP1 Antibody (YA3233)
(Synonyms: CHO1; KNSL5; MKLP1; MKLP-1)MKLP1 Antibody (YA3233) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MKLP1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF
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Reactivity :
Human
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Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Conjugation:
Non-conjugated
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:200-500 |
Product Details
MKLP1 Antibody (YA3233) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MKLP1.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 110 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 110 kDa
A synthetic peptide of human MKLP1 aa814-827.
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
MKLP1 component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro
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Subcellular Localization
Nucleus; Cytoplasm, cytoskeleton, spindle; Midbody, Midbody ring
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Expression
Tissue_specificity:Widely expressed -
Isoforms & Post-Translational Modification
Q02241 has 3 isomers: Q02241-1: 110059 Da (predicted); Q02241-2: 98105 Da (predicted); Q02241-3: 77699 Da (predicted).
Ubiquitinated. Deubiquitinated by USP8/UBPY -
Subunit
Heterotetramer of two molecules each of RACGAP1 and KIF23. Found in the centralspindlin complex. Interacts with RACGAP1; the interaction is direct. Interacts with ECT2 and PRC1.
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SwissProt ID
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Synonyms
CHO1; KNSL5; MKLP1; MKLP-1
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Research Field
Cell Biology
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