RND1 - Rho family GTPase 1 Gene

Also Known as ARHS; RHO6; RHOS

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 27289

About RND1

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:48,857,145-48,865,870 (from NCBI)

This gene has 6 transcripts (splice variants), 261 orthologues and 22 paralogues. Biased expression in liver (RPKM 28.4), brain (RPKM 15.0) and 9 other tissues.

Summary

This gene encodes a protein that belongs to the Rho GTPase family. Members of this family regulate the organization of the actin Cytoskeleton in response to extracellular growth factors. A similar protein in rat interacts with a microtubule regulator to control axon extension. [provided by RefSeq, Apr 2014]

RND1 Products (1)

mRNA	Protein	Name
NM_014470.4	NP_055285.1	rho-related GTP-binding protein Rho6 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10664463	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	19843518	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in actin filament organization	IDA IDA: Inferred from direct assay	9531558	GOA
involved in negative regulation of cell adhesion	IDA IDA: Inferred from direct assay	9531558	GOA
involved in neuron remodeling	IDA IDA: Inferred from direct assay	11095956	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in adherens junction	IDA IDA: Inferred from direct assay	9531558	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RND1 Protein Structure

Ras

0
100
200
232 a.a.

Protein Preferred Names	Protein Names
rho-related GTP-binding protein Rho6	ras homolog gene family, member S

RND1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RND1	Q92730	PLXNB1	Homo sapiens	O43157	Y2H	12730235
Intra	RND1	Q92730	PLXNB1	Homo sapiens	O43157	Affinity Techniques	14732713
Intra	RND1	Q92730	PLXNB1	Homo sapiens	O43157	ITC	29040270
Intra	RND1	Q92730	PLXNB1	Homo sapiens	O43157	GMS	29040270
Intra	RND1	Q92730	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	RND1	Q92730	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	RND1	Q92730	PLXNB1	Homo sapiens	O43157-1	Anti Tag CoIP	25531777
Intra	RND1	Q92730	ARFIP2	Homo sapiens	P53365	Y2H Array	32296183
Intra	RND1	Q92730	ARFIP2	Homo sapiens	P53365	Y2H Prey Pooling	32296183
Intra	RND1	Q92730	PLXNB2	Homo sapiens	O15031	ITC	29040270
Intra	RND1	Q92730	PLXNB2	Homo sapiens	O15031	GMS	29040270
Intra	RND1	Q92730	GRB7	Homo sapiens	Q14451	Anti Bait CoIP	10664463
Intra	RND1	Q92730	GRB7	Homo sapiens	Q14451	Pull Down	10664463

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Ascaridiasis	Ascariasis
Deafness, Autosomal Recessive 104	DFNB104 Autosomal Recessive Nonsyndromic Deafness 104 Autosomal Recessive Deafness 104 Deafness, Autosomal Recessive, 104 Deafness, Autosomal Recessive, Type 104
Toxic Megacolon	Megacolon, Toxic Toxic Dilatation Of Colon Toxic Functional Megacolon
Clostridium Difficile Colitis	Pseudomembranous Colitis Colitis Pseudomembranous Enterocolitis, Pseudomembranous Pseudomembranous Enterocolitis Clostridium Difficile Infection

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12031	RND1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21425	Rnd1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27943	Rnd1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RND1	VGNC	VGNC:45616
Felis catus	RND1	VGNC	VGNC:64661
Bos taurus	RND1	VGNC	VGNC:34004
Mus musculus	RND1	MGD	MGI:2444878
Rattus norvegicus	RND1	RGD	RGD:1306338
Macaca mulatta	RND1	VGNC	VGNC:100101
Others	RND1	NCBI