GRB7 - growth factor receptor bound protein 7 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2886

About GRB7

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:39,737,938-39,747,285 (from NCBI)

This gene has 14 transcripts (splice variants), 197 orthologues and 4 paralogues. Broad expression in kidney (RPKM 6.4), esophagus (RPKM 5.5) and 16 other tissues.

Summary

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of Receptor Tyrosine Kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the Integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

GRB7 Products (5)

mRNA	Protein	Name
NM_001030002.3	NP_001025173.1	growth factor receptor-bound protein 7 isoform a
NM_001242442.2	NP_001229371.2	growth factor receptor-bound protein 7 isoform b
NM_001242443.2	NP_001229372.1	growth factor receptor-bound protein 7 isoform a
NM_001330207.2	NP_001317136.1	growth factor receptor-bound protein 7 isoform c
NM_005310.5	NP_005301.2	growth factor receptor-bound protein 7 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	15841400	GOA
enables phosphatidylinositol binding	IDA IDA: Inferred from direct assay	12021278	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8940081	GOA
enables protein kinase binding	IDA IDA: Inferred from direct assay	12021278	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	10893408	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	10893408	GOA
located in focal adhesion	IDA IDA: Inferred from direct assay	10893408	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GRB7 Protein Structure

BPS

SH2

0
100
200
300
400
500
532 a.a.

Protein Preferred Names	Protein Names
growth factor receptor-bound protein 7	B47

GRB7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GRB7	Q14451	LAX1	Homo sapiens	Q8IWV1	Validated Y2H	25416956
Intra	GRB7	Q14451	LAX1	Homo sapiens	Q8IWV1	Y2H Prey Pooling	25416956
Intra	GRB7	Q14451	KIT	Homo sapiens	P10721	FPS	24728074
Intra	GRB7	Q14451	TRIM36	Homo sapiens	Q9NQ86	Validated Y2H	25416956
Intra	GRB7	Q14451	KCTD6	Homo sapiens	Q8NC69	Validated Y2H	25416956
Intra	GRB7	Q14451	KCTD6	Homo sapiens	Q8NC69	Y2H Prey Pooling	25416956
Intra	GRB7	Q14451	HAX1	Homo sapiens	O00165	Anti Bait CoIP	20665473
Intra	GRB7	Q14451	OLIG1	Homo sapiens	Q8TAK6	Lumier	25814554
Intra	GRB7	Q14451	RND1	Homo sapiens	Q92730	Y2H	10664463
Intra	GRB7	Q14451	AR	Homo sapiens	P10275	FPS	24728074
Intra	GRB7	Q14451	ERBB2	Homo sapiens	P04626	NMR	12975581
Intra	GRB7	Q14451	ERBB2	Homo sapiens	P04626	Protein Array	16273093
Intra	GRB7	Q14451	PDGFRB	Homo sapiens	P09619	Pull Down	8940081
Intra	GRB7	Q14451	PDGFRB	Homo sapiens	P09619	Competition Binding	8940081
Intra	GRB7	Q14451	LY6G6F	Homo sapiens	Q5SQ64	Anti Tag CoIP	12852788
Intra	GRB7	Q14451	PTK2	Homo sapiens	Q05397	Y2H Array	25814554
Intra	GRB7	Q14451	PTK2	Homo sapiens	Q05397	Lumier	25814554
Intra	GRB7	Q14451	ERBB3	Homo sapiens	P21860	Competition Binding	9516479
Intra	GRB7	Q14451	ERBB3	Homo sapiens	P21860	Protein Array	16273093
Intra	GRB7	Q14451	EPHB1	Homo sapiens	P54762	Y2H	12223469
Cross	GRB7	Q14451	CALM	Bos taurus	P62157	Pull Down	15806159
Cross	GRB7	Q14451	Calm1	Rattus norvegicus	P0DP29	Far-WB	15806159
Cross	GRB7	Q14451	Calm1	Rattus norvegicus	P0DP29	Filter Binding	15806159

Cross: Cross-species interaction Intra: Intraspecies interaction

GRB7 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81420	GRB7 Antibody (YA1165)	IHC-P	Human
HY-P81420A	GRB7 Antibody (YA1165)(PBS only)	IHC-P	Human

Related Diseases

Diseases	Alias
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Esophageal Cancer	Esophageal Carcinoma Carcinoma Of Esophagus Esophageal Squamous Cell Carcinoma, Somatic Esophageal Carcinoma, Somatic Esophagus Cancer Gastric Cardia Adenocarcinoma Esophageal Neoplasms Esophageal Cancer, Somatic Cancer Of Esophagus Cancer Of Oesophagus Carcinoma Of Oesophagus Ca Lower Third Oesophagus Ca Middle Third Oesophagus Malignant Neoplasm Of Distal Third Of Esophagus Malignant Neoplasm Of Lower Third Of Oesophagus Malignant Neoplasm Of Middle Third Of Oesophagus Malignant Neoplasm Of Proximal Third Of Esophagus Malignant Neoplasm Of Upper Third Esophagus Malignant Tumor Of Abdominal Esophagus Malignant Tumor Of Distal Third Of Esophagus Malignant Tumor Of Proximal Third Of Esophagus Malignant Tumor Of The Middle Third Of The Esophagus ESCR Aerodigestive Tract Cancer Escc Esophageal Squamous Cell Carcinoma Cancer, Esophageal Malignant Neoplasm Of Esophagus Squamous Cell Carcinoma Of Esophagus Malignant Neoplasm Of Middle Third Of Esophagus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P10224A	G7-18NATE TFA		98.06%	Unkown
HY-N14349	Asterriquinone	Inhibitor	/	Unkown
HY-P10224	G7-18NATE		/	Unkown
HY-RS05781	GRB7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-180480	NSC 104999	Ligand	/	Unkown
HY-180498	NSC 57148	Inhibitor	/	Unkown
HY-RS20748	Grb7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27260	Grb7 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GRB7	MGD	MGI:102683
Macaca mulatta	GRB7	VGNC	VGNC:73270
Canis familiaris	GRB7	VGNC	VGNC:41473
Bos taurus	GRB7	VGNC	VGNC:29632
Rattus norvegicus	GRB7	RGD	RGD:619759
Felis catus	GRB7	VGNC	VGNC:67458
Others	GRB7	NCBI