2. Gene
  3. PTK2 - protein tyrosine kinase 2 Gene

PTK2 - protein tyrosine kinase 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as FAK; FADK; FAK1; FRNK; FADK 1; PPP1R71; p125FAK; pp125FAK

Gene ID: 5747 | Gene type: protein coding

About PTK2

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:140,657,900-141,002,079 (from NCBI)

This gene has 58 transcripts (splice variants), 230 orthologues and 32 paralogues. Ubiquitous expression in brain (RPKM 21.7), placenta (RPKM 17.8) and 25 other tissues.

Summary

This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of Protein Tyrosine Kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural Peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]

PTK2 Products(181)

mRNA Protein Name
XM_024447208.2 XP_024302976.1 focal adhesion kinase 1 isoform X28
NM_001387591.1 NP_001374520.1 focal adhesion kinase 1 isoform 54
NM_001387649.1 NP_001374578.1 focal adhesion kinase 1 isoform 63
NM_001352715.2 NP_001339644.1 focal adhesion kinase 1 isoform 14
NM_001352707.2 NP_001339636.1 focal adhesion kinase 1 isoform 10
NM_001387657.1 NP_001374586.1 focal adhesion kinase 1 isoform 1
NR_148038.2
NM_001387661.1 NP_001374590.1 focal adhesion kinase 1 isoform 65
NM_001387650.1 NP_001374579.1 focal adhesion kinase 1 isoform 65
NM_001316342.2 NP_001303271.1 focal adhesion kinase 1 isoform 4
NM_001387603.1 NP_001374532.1 focal adhesion kinase 1 isoform 55
NM_001387644.1 NP_001374573.1 focal adhesion kinase 1 isoform 62
XM_047422027.1 XP_047277983.1 focal adhesion kinase 1 isoform X10
NM_001352716.2 NP_001339645.1 focal adhesion kinase 1 isoform 15
XM_047422023.1 XP_047277979.1 focal adhesion kinase 1 isoform X6
NM_001387592.1 NP_001374521.1 focal adhesion kinase 1 isoform 71
NM_001352739.2 NP_001339668.1 focal adhesion kinase 1 isoform 33
NM_001352748.2 NP_001339677.1 focal adhesion kinase 1 isoform 41
XM_047422036.1 XP_047277992.1 focal adhesion kinase 1 isoform X21
NM_005607.5 NP_005598.3 focal adhesion kinase 1 isoform 2
XM_047422054.1 XP_047278010.1 focal adhesion kinase 1 isoform X38
NM_001352700.2 NP_001339629.1 focal adhesion kinase 1 isoform 7
NM_001352745.2 NP_001339674.1 focal adhesion kinase 1 isoform 38
NM_001352736.2 NP_001339665.1 focal adhesion kinase 1 isoform 30
NM_001387620.1 NP_001374549.1 focal adhesion kinase 1 isoform 4
XM_047422025.1 XP_047277981.1 focal adhesion kinase 1 isoform X8
NM_001352701.2 NP_001339630.1 focal adhesion kinase 1 isoform 7
NM_001352724.2 NP_001339653.1 focal adhesion kinase 1 isoform 19
NM_001387643.1 NP_001374572.1 focal adhesion kinase 1 isoform 65
XM_047422049.1 XP_047278005.1 focal adhesion kinase 1 isoform X24
NR_148036.2
NM_001387623.1 NP_001374552.1 focal adhesion kinase 1 isoform 56
NM_001387617.1 NP_001374546.1 focal adhesion kinase 1 isoform 71
NM_001352732.2 NP_001339661.1 focal adhesion kinase 1 isoform 27
XM_047422046.1 XP_047278002.1 focal adhesion kinase 1 isoform X33
NM_001387614.1 NP_001374543.1 focal adhesion kinase 1 isoform 59
NR_170673.1
XM_047422030.1 XP_047277986.1 focal adhesion kinase 1 isoform X13
NM_001352698.2 NP_001339627.1 focal adhesion kinase 1 isoform 6
NM_001352740.2 NP_001339669.1 focal adhesion kinase 1 isoform 34
NM_001352694.2 NP_001339623.1 focal adhesion kinase 1 isoform 1
NM_001387619.1 NP_001374548.1 focal adhesion kinase 1 isoform 23
NM_001387587.1 NP_001374516.1 focal adhesion kinase 1 isoform 1
XM_047422018.1 XP_047277974.1 focal adhesion kinase 1 isoform X3
NM_001387618.1 NP_001374547.1 focal adhesion kinase 1 isoform 56
NM_001352752.2 NP_001339681.1 focal adhesion kinase 1 isoform 45
NM_001352705.2 NP_001339634.1 focal adhesion kinase 1 isoform 9
NM_001352747.2 NP_001339676.1 focal adhesion kinase 1 isoform 40
NM_001387627.1 NP_001374556.1 focal adhesion kinase 1 isoform 60
XM_047422026.1 XP_047277982.1 focal adhesion kinase 1 isoform X9
NM_001387633.1 NP_001374562.1 focal adhesion kinase 1 isoform 68
NM_001352723.2 NP_001339652.1 focal adhesion kinase 1 isoform 18
NM_001387647.1 NP_001374576.1 focal adhesion kinase 1 isoform 1
NM_001352749.2 NP_001339678.1 focal adhesion kinase 1 isoform 42
XM_047422038.1 XP_047277994.1 focal adhesion kinase 1 isoform X23
NM_001352731.2 NP_001339660.1 focal adhesion kinase 1 isoform 26
XM_047422053.1 XP_047278009.1 focal adhesion kinase 1 isoform X24
NM_001387655.1 NP_001374584.1 focal adhesion kinase 1 isoform 1
NM_001387660.1 NP_001374589.1 focal adhesion kinase 1 isoform 65
NM_001352733.2 NP_001339662.1 focal adhesion kinase 1 isoform 28
NM_001352711.2 NP_001339640.1 focal adhesion kinase 1 isoform 11
XM_047422050.1 XP_047278006.1 focal adhesion kinase 1 isoform X36
NM_001387625.1 NP_001374554.1 focal adhesion kinase 1 isoform 20
NM_001387632.1 NP_001374561.1 focal adhesion kinase 1 isoform 59
NM_001352703.2 NP_001339632.1 focal adhesion kinase 1 isoform 7
NM_001352710.2 NP_001339639.1 focal adhesion kinase 1 isoform 10
XM_047422032.1 XP_047277988.1 focal adhesion kinase 1 isoform X15
NM_001387612.1 NP_001374541.1 focal adhesion kinase 1 isoform 56
NM_001387651.1 NP_001374580.1 focal adhesion kinase 1 isoform 69
NM_001352725.2 NP_001339654.1 focal adhesion kinase 1 isoform 20
XM_047422020.1 XP_047277976.1 focal adhesion kinase 1 isoform X4
NM_001387613.1 NP_001374542.1 focal adhesion kinase 1 isoform 35
NM_001387662.1 NP_001374591.1 focal adhesion kinase 1 isoform 61
NM_001387630.1 NP_001374559.1 focal adhesion kinase 1 isoform 52
NM_001352743.2 NP_001339672.1 focal adhesion kinase 1 isoform 47
NM_001352744.2 NP_001339673.1 focal adhesion kinase 1 isoform 37
NM_001352728.2 NP_001339657.1 focal adhesion kinase 1 isoform 23
NM_001387610.1 NP_001374539.1 focal adhesion kinase 1 isoform 52
NM_001352695.2 NP_001339624.1 focal adhesion kinase 1 isoform 48
NM_001387658.1 NP_001374587.1 focal adhesion kinase 1 isoform 1
XM_047422047.1 XP_047278003.1 focal adhesion kinase 1 isoform X34
NM_001352697.2 NP_001339626.1 focal adhesion kinase 1 isoform 5
NM_001352737.2 NP_001339666.1 focal adhesion kinase 1 isoform 31
NM_001352719.2 NP_001339648.1 focal adhesion kinase 1 isoform 17
NM_001352706.2 NP_001339635.1 focal adhesion kinase 1 isoform 10
NM_001387636.1 NP_001374565.1 focal adhesion kinase 1 isoform 1
NM_001352714.2 NP_001339643.1 focal adhesion kinase 1 isoform 13
XM_047422037.1 XP_047277993.1 focal adhesion kinase 1 isoform X22
XM_047422019.1 XP_047277975.1 focal adhesion kinase 1 isoform X4
NM_001352712.2 NP_001339641.1 focal adhesion kinase 1 isoform 12
NM_001387639.1 NP_001374568.1 focal adhesion kinase 1 isoform 10
NM_001352742.2 NP_001339671.1 focal adhesion kinase 1 isoform 36
NM_001387615.1 NP_001374544.1 focal adhesion kinase 1 isoform 21
NM_001387624.1 NP_001374553.1 focal adhesion kinase 1 isoform 15
NR_170671.1
NM_001387648.1 NP_001374577.1 focal adhesion kinase 1 isoform 65
XM_047422039.1 XP_047277995.1 focal adhesion kinase 1 isoform X24
NM_001352734.2 NP_001339663.1 focal adhesion kinase 1 isoform 29
XM_024447203.2 XP_024302971.1 focal adhesion kinase 1 isoform X17
NM_001352750.2 NP_001339679.1 focal adhesion kinase 1 isoform 43
XM_047422044.1 XP_047278000.1 focal adhesion kinase 1 isoform X31
NM_001387642.1 NP_001374571.1 focal adhesion kinase 1 isoform 1
NM_001387656.1 NP_001374585.1 focal adhesion kinase 1 isoform 20
NM_001352696.2 NP_001339625.1 focal adhesion kinase 1 isoform 4
NM_001352751.2 NP_001339680.1 focal adhesion kinase 1 isoform 44
NM_001352721.2 NP_001339650.1 focal adhesion kinase 1 isoform 18
NM_001387654.1 NP_001374583.1 focal adhesion kinase 1 isoform 56
NM_001387638.1 NP_001374567.1 focal adhesion kinase 1 isoform 17
NM_001387645.1 NP_001374574.1 focal adhesion kinase 1 isoform 1
NM_001352717.2 NP_001339646.1 focal adhesion kinase 1 isoform 16
XM_047422029.1 XP_047277985.1 focal adhesion kinase 1 isoform X12
XM_047422022.1 XP_047277978.1 focal adhesion kinase 1 isoform X5
NM_001352713.2 NP_001339642.1 focal adhesion kinase 1 isoform 13
NM_001387584.1 NP_001374513.1 focal adhesion kinase 1 isoform 56
NM_001352704.2 NP_001339633.1 focal adhesion kinase 1 isoform 8
NM_001387611.1 NP_001374540.1 focal adhesion kinase 1 isoform 57
NM_001387652.1 NP_001374581.1 focal adhesion kinase 1 isoform 56
XM_047422028.1 XP_047277984.1 focal adhesion kinase 1 isoform X11
NM_001387628.1 NP_001374557.1 focal adhesion kinase 1 isoform 1
NM_001199649.2 NP_001186578.1 focal adhesion kinase 1 isoform 3
XM_024447209.2 XP_024302977.1 focal adhesion kinase 1 isoform X30
NM_001352709.2 NP_001339638.1 focal adhesion kinase 1 isoform 10
XM_024447207.2 XP_024302975.1 focal adhesion kinase 1 isoform X27
NM_001387646.1 NP_001374575.1 focal adhesion kinase 1 isoform 65
NM_001387607.1 NP_001374536.1 focal adhesion kinase 1 isoform 58
NM_001387631.1 NP_001374560.1 focal adhesion kinase 1 isoform 15
NM_001352741.2 NP_001339670.1 focal adhesion kinase 1 isoform 35
NM_001387653.1 NP_001374582.1 focal adhesion kinase 1 isoform 23
XM_047422035.1 XP_047277991.1 focal adhesion kinase 1 isoform X20
NM_001387637.1 NP_001374566.1 focal adhesion kinase 1 isoform 1
XM_047422043.1 XP_047277999.1 focal adhesion kinase 1 isoform X29
NM_001387588.1 NP_001374517.1 focal adhesion kinase 1 isoform 69
NM_001387608.1 NP_001374537.1 focal adhesion kinase 1 isoform 56
XM_047422041.1 XP_047277997.1 focal adhesion kinase 1 isoform X26
XM_047422031.1 XP_047277987.1 focal adhesion kinase 1 isoform X14
XM_047422017.1 XP_047277973.1 focal adhesion kinase 1 isoform X2
NM_001352720.2 NP_001339649.1 focal adhesion kinase 1 isoform 17
NM_001387586.1 NP_001374515.1 focal adhesion kinase 1 isoform 1
NM_001352718.2 NP_001339647.1 focal adhesion kinase 1 isoform 17
NM_001387621.1 NP_001374550.1 focal adhesion kinase 1 isoform 71
NM_001387622.1 NP_001374551.1 focal adhesion kinase 1 isoform 16
NM_001387606.1 NP_001374535.1 focal adhesion kinase 1 isoform 33
NM_001352746.2 NP_001339675.1 focal adhesion kinase 1 isoform 39
XM_047422040.1 XP_047277996.1 focal adhesion kinase 1 isoform X25
NM_001387604.1 NP_001374533.1 focal adhesion kinase 1 isoform 49
NM_001387659.1 NP_001374588.1 focal adhesion kinase 1 isoform 17
XM_047422034.1 XP_047277990.1 focal adhesion kinase 1 isoform X19
NM_001352729.2 NP_001339658.1 focal adhesion kinase 1 isoform 24
NR_170670.1
NM_001352730.2 NP_001339659.1 focal adhesion kinase 1 isoform 25
NM_001387635.1 NP_001374564.1 focal adhesion kinase 1 isoform 53
XM_047422052.1 XP_047278008.1 focal adhesion kinase 1 isoform X37
XM_047422048.1 XP_047278004.1 focal adhesion kinase 1 isoform X35
NM_153831.4 NP_722560.1 focal adhesion kinase 1 isoform 1
NM_001352702.2 NP_001339631.1 focal adhesion kinase 1 isoform 7
NM_001352699.2 NP_001339628.1 focal adhesion kinase 1 isoform 7
NM_001387609.1 NP_001374538.1 focal adhesion kinase 1 isoform 35
XM_047422024.1 XP_047277980.1 focal adhesion kinase 1 isoform X7
XM_047422033.1 XP_047277989.1 focal adhesion kinase 1 isoform X18
NM_001387640.1 NP_001374569.1 focal adhesion kinase 1 isoform 64
NM_001387589.1 NP_001374518.1 focal adhesion kinase 1 isoform 70
NM_001352726.2 NP_001339655.1 focal adhesion kinase 1 isoform 21
NM_001352722.2 NP_001339651.1 focal adhesion kinase 1 isoform 18
NM_001352735.2 NP_001339664.1 focal adhesion kinase 1 isoform 46
NR_148037.2
NR_170672.1
XM_047422045.1 XP_047278001.1 focal adhesion kinase 1 isoform X32
NM_001352727.2 NP_001339656.1 focal adhesion kinase 1 isoform 22
NM_001387641.1 NP_001374570.1 focal adhesion kinase 1 isoform 72
NM_001387585.1 NP_001374514.1 focal adhesion kinase 1 isoform 59
NM_001387629.1 NP_001374558.1 focal adhesion kinase 1 isoform 50
NM_001387634.1 NP_001374563.1 focal adhesion kinase 1 isoform 14
XM_047422021.1 XP_047277977.1 focal adhesion kinase 1 isoform X4
NM_001387605.1 NP_001374534.1 focal adhesion kinase 1 isoform 56
NM_001387616.1 NP_001374545.1 focal adhesion kinase 1 isoform 71
NM_001352708.2 NP_001339637.1 focal adhesion kinase 1 isoform 10
XM_024447202.2 XP_024302970.1 focal adhesion kinase 1 isoform X16
NM_001352738.2 NP_001339667.1 focal adhesion kinase 1 isoform 32
XM_047422016.1 XP_047277972.1 focal adhesion kinase 1 isoform X1
NR_148039.2
NM_001387590.1 NP_001374519.1 focal adhesion kinase 1 isoform 53

PTK2 Protein Structure

FERM_M

FERM_M: FERM central domain (138 - 249)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (422 - 676)

Focal_AT

Focal_AT: Focal adhesion targeting region (914 - 1051)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1052 a.a.
Protein Preferred Names Protein Names

focal adhesion kinase 1

FAK-related non-kinase polypeptide

PTK2 protein tyrosine kinase 2

focal adhesion kinase-related nonkinase

protein phosphatase 1 regulatory subunit 71

Related Diseases

Diseases Alias
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Protection Against

Lung Cancer, Susceptibility To

Adenocarcinoma Of Lung, Somatic

Nonsmall Cell Lung Cancer

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Breast Cancer

Breast Carcinoma

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Male Breast Cancer

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Glanzmann Thrombasthenia 1

Glanzmann Thrombasthenia

Thrombasthenia Of Glanzmann And Naegeli

Bdplt2

Platelet Glycoprotein Iib-Iiia Deficiency

Glanzmann'S Thrombasthenia

Deficiency Of Platelet Fibrinogen Receptor

GT1

Gt

Platelet Fibrinogen Receptor Deficiency

Glycoprotein Complex Iib-Iiia Deficiency

Deficiency Of Glycoprotein Complex Iib-Iiia

Glycoprotein Iib/Iiia Defect

Glanzmann Thrombasthenia, Type A

Thrombasthenia

Bleeding Disorder, Platelet-Type, 2

Gp Iib-Iiia Complex Deficiency

Deficiency Of Gp Iib-Iiia Complex

Platelet-Type Bleeding Disorder 2

Thrombocytasthenia

Deficiency Of Gp 2b 3a Complex

Diacyclothrombopathia 2b 3a

Glanzmann Thrombasthenia Type A

Platelet Fibrinogen Receptor, Deficiency Of

Platelet Glycoprotein 2b 3a Deficiency

Glanzmann Disease

Glanzmann-Naegeli Disorder

Hereditary Hemorrhagic Thrombasthenia

Hereditary Thrombasthenia

Bleeding Disorder Platelet-Type 2
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Cancer Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Focal Segmental Glomerulosclerosis

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome

Focal Glomerulosclerosis

Fsgs

Segmental Glomerulosclerosis

Glomerulosclerosis, Focal Segmental

Fgs

Focal Glomerular Sclerosis

Familial Idiopathic Nephrotic Syndrome

Focal Sclerosis With Hyalinosis

Glomerulosclerosis, Focal

Glomerulosclerosis Focal

Glomerulosclerosis, Segmental, Focal

Focal Segmental Glomerulosclerosis, Not Otherwise Specified
Colon Adenocarcinoma

Adenocarcinoma Of Colon

Adenocarcinoma Of The Colon

Colonic Adenocarcinoma
Nephrotic Syndrome, Type 10

NPHS10

Nephrotic Syndrome Type 10

Idiopathic Steroid-Sensitive Nephrotic Syndrome

Nephrotic Syndrome 10
Malignant Pleural Mesothelioma

Malignant Mesothelioma Of Pleura

Pleural Malignant Mesothelioma
Thrombasthenia
Laryngeal Squamous Cell Carcinoma

Epidermoid Carcinoma Of The Larynx

Squamous Cell Carcinoma Of Larynx

Squamous Cell Carcinoma Of The Larynx

Squamous Cell Carcinoma Of Head And Neck
Squamous Cell Carcinoma, Head And Neck

Squamous Cell Carcinoma Of The Head And Neck

HNSCC

Head And Neck Squamous Cell Carcinoma

Head And Neck Cancer

Squamous Cell Carcinoma Of Lip

Squamous Cell Carcinoma, Head And Neck, Somatic

Carcinoma Of The Head And Neck

Squamous Cell Carcinomas Of Head And Neck

Scchn

Squamous Cell Carcinoma Of The Hypopharynx

Squamous Cell Carcinoma Of The Oropharynx

Squamous Cell Carcinoma Of Salivary Glands

Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses

Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses

Squamous Cell Carcinoma Of The Oral Cavity

Squamous Cell Carcinoma Of The Lip

Carcinoma, Squamous Cell Of Head And Neck

Lip Squamous Cell Carcinoma

Cancer, Head/Neck

Carcinoma, Squamous Cell, Head And Neck

Salivary Gland Squamous Cell Carcinoma

Cancer Of Head And Neck

Squamous Cell Carcinoma Of Oropharynx Nos
Pancreatic Cancer

Pancreatic Carcinoma

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Carcinoma Of Pancreas

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Cancer Of The Pancreas

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma
Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia

Chronic Myelogenous Leukemia

CML

Chronic Granulocytic Leukemia

Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib

Chronic Myeloid Leukaemia

Chronic Granulocytic Leukaemia

Chronic Myelogenous Leukaemia

Myeloid Leukemia, Chronic

Leukemia, Chronic Myelogenous

Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic

Cml - Chronic Myelogenous Leukemia

Cgl

Chronic Myelocytic Leukemia

Leukemia, Chronic Myeloid, Atypical

ACML

Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative

Myeloid Leukemia Chronic

Leukemia, Myeloid, Chronic

Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative

Cml- [Chronic Myeloid Leukaemia]

Cgl - [Chronic Granulocytic Leukaemia]

Chronic Myelocytic Leukaemia
Melanoma, Uveal

Uveal Melanoma

Choroidal Melanoma

Melanoma Of Uvea

Iris Melanoma

Malignant Melanoma Of Choroid

Malignant Melanoma Of Iris
Esophageal Cancer

Esophageal Carcinoma

Carcinoma Of Esophagus

Esophageal Squamous Cell Carcinoma, Somatic

Esophageal Carcinoma, Somatic

Esophagus Cancer

Gastric Cardia Adenocarcinoma

Esophageal Neoplasms

Esophageal Cancer, Somatic

Cancer Of Esophagus

Cancer Of Oesophagus

Carcinoma Of Oesophagus

Ca Lower Third Oesophagus

Ca Middle Third Oesophagus

Malignant Neoplasm Of Distal Third Of Esophagus

Malignant Neoplasm Of Lower Third Of Oesophagus

Malignant Neoplasm Of Middle Third Of Oesophagus

Malignant Neoplasm Of Proximal Third Of Esophagus

Malignant Neoplasm Of Upper Third Esophagus

Malignant Tumor Of Abdominal Esophagus

Malignant Tumor Of Distal Third Of Esophagus

Malignant Tumor Of Proximal Third Of Esophagus

Malignant Tumor Of The Middle Third Of The Esophagus

ESCR

Aerodigestive Tract Cancer

Escc

Esophageal Squamous Cell Carcinoma

Cancer, Esophageal

Malignant Neoplasm Of Esophagus

Squamous Cell Carcinoma Of Esophagus

Malignant Neoplasm Of Middle Third Of Esophagus
Cholangiocarcinoma

Cholangiocarcinoma, Susceptibility To

Extrahepatic Cholangiocarcinoma

Intrahepatic Cholangiocarcinoma

Chlc

Chlc, Susceptibility To

Cc

Cholangiocarcinoma Of Biliary Tract

Cholangiocellular Carcinoma

Distal Cholangiocarcinoma

Perihilar Cholangiocarcinoma

Bile Duct Cancer

Cca

Adult Primary Cholangiocellular Carcinoma

Bile Duct Carcinoma
Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma
Fibrosarcoma

Neoplasms, Fibrous Tissue

Fibrocytic Tumor

Fibrosarcoma Of Soft Tissue

Fibrous Tissue Neoplasm
Lung Cancer Susceptibility 3

Lung Adenocarcinoma

Adenocarcinoma Of Lung

LNCR3

Adenocarcinoma Of Lung, Susceptibility To

Bronchogenic Lung Adenocarcinoma

Nonsmall Cell Adenocarcinoma

Adenocarcinoma Lung

Lung Adenocarcinomas

Non-Small Cell Adenocarcinoma
Heart Disease

Heart Failure

Congenital Heart Disease

Heart Diseases

Congenital Heart Defects

Congenital Heart Defect

Congenital Anomaly Of Heart

Heart Defect

Heart Malformation

Heart-Congenital Defect

Congenital Heart Disorder

Heart Defects Congenital

Heart Defects, Congenital

Heart Defects

Heart Disease, Congenital

Disease, Heart, Congenital

Congestive Heart Failure
Endometrial Cancer

Endometrial Carcinoma

Endometrial Neoplasm

Malignant Neoplasm Of Endometrium

Endometrioid Carcinoma

Endometrial Neoplasms

Carcinoma, Endometrioid

Endometrial Cancer, Familial

Endometrial Carcinoma, Somatic

Endometrial Cancer, Susceptibility To

Endometrial Ca

Malignant Endometrial Neoplasm

Neoplasm Of Endometrium

Primary Malignant Neoplasm Of Endometrium

Tumor Of Endometrium

Carcinoma Of The Endometrium

Endometrioid Carcinoma Of Female Reproductive System

ENDMC

Carcinoma Endometrioid

Endometrial Cancers

Cancer, Endometrial

Uterine Corpus Cancer
Glioma
Rhabdomyosarcoma
Ewing Sarcoma

Neuroepithelioma

Ewing'S Tumor

Ewings Sarcoma

Ewing'S Sarcoma

Peripheral Neuroepithelioma

Primitive Neuroectodermal Tumor

ES

Ewings Sarcoma-Primitive Neuroectodermal Tumor

Localized Peripheral Primitive Neuroectodermal Tumor

Peripheral Primitive Neuroectodermal Tumor

Ewing Tumor

Sarcoma, Ewing'S

Extraosseous Ewing Tumor

Askin Tumor

Ewing'S Family Localized Tumor

Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Localized Ewing Sarcoma

Localized Ewing'S Sarcoma

Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Localized Ewing'S Tumor

Pnet Of Thoracopulmonary Region

Ewing Family Of Tumors

Tumor Of The Ewing Family

Skeletal Ewing Sarcoma

Osseous Ewing Sarcoma

Ppnet

Peripheral Pnet

Extraskeletal Ewing Sarcoma

Eoe

Extraosseous Ewing Sarcoma

Extraskeletal Ewing Tumor

Esft

Ewing Sarcoma Family Of Tumors

Pne

Pnet

Pnet Of The Chest Wall

Sarcoma, Ewing

Neuroectodermal Tumors, Primitive, Peripheral

Neuroectodermal Tumor, Primitive

Disorder Of Eye

Askin'S Tumor

Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor

Neuroepithelioma, Peripheral
Prion Disease

Spongiform Encephalopathy

Transmissible Spongiform Encephalopathies

Prion Diseases

Prion Disease Pathway

Transmissible Spongiform Encephalopathy

Prion Induced Disorder

Prion Protein Disease

Inherited Human Transmissible Spongiform Encephalopathies

Prion Protein Diseases

Prion-Associated Disorders

Prion-Induced Disorders

Transmissible Dementias

Tses

Human Prion Disease

Tse

Encephalopathy, Transmissible Spongiform

Prion Disease, Susceptibility To

Spongiform Encephalopathies

Human Transmissible Spongiform Encephalopathies, Inherited
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (15)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-111546 BI-3663 Inhibitor 99.90% Unkown
HY-123919 TL13-112 Inhibitor 98.15% Unkown
HY-124625 BI-4464 Inhibitor 99.27% Unkown
HY-148063 DB0614 98.80% Unkown
HY-122582 TL13-12 Inhibitor 98.06% Unkown
HY-130422 Tos-PEG4-t-butyl ester ≥97.0% Unkown
HY-148061 DB1113 99.28% Unkown
HY-130521 Pomalidomide-amido-PEG3-C2-NH2 99.55% Unkown
HY-136194 TL13-22 Inhibitor / Unkown
HY-136195 TL13-110 Inhibitor / Unkown
HY-148065 FMF-06-098-1 / Unkown
HY-RS11399 PTK2 Human Pre-designed siRNA Set A / Unkown
HY-RS11400 Ptk2 Mouse Pre-designed siRNA Set A / Unkown
HY-RS11401 Ptk2 Rat Pre-designed siRNA Set A / Unkown
HY-RS11402 PTK2B Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PTK2 MGD MGI:95481
Rattus norvegicus PTK2 RGD RGD:3443
Macaca mulatta PTK2 VGNC VGNC:84105
Bos taurus PTK2 VGNC VGNC:33518
Felis catus PTK2 VGNC VGNC:82498
Canis familiaris PTK2 VGNC VGNC:45158
Others PTK2 NCBI