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  3. Tos-PEG4-t-butyl ester

Tos-PEG4-t-butyl ester (Synonyms: Tos-PEG4-Boc)

Cat. No.: HY-130422 Purity: 97.44%
Handling Instructions

Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) is a PROTAC linker, which refers to the PEG composition. Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) can be used in the synthesis of a series of PROTACs, such as BI-3663 (HY-111546). BI-3663 is a highly selective PTK2/FAK PROTAC, with cereblon ligands to hijack E3 ligases for PTK2 degradation, and inhibits PTK2 with an IC50 of 18 nM.

For research use only. We do not sell to patients.

Tos-PEG4-t-butyl ester Chemical Structure

Tos-PEG4-t-butyl ester Chemical Structure

CAS No. : 217817-01-1

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 50 In-stock
Estimated Time of Arrival: December 31
25 mg USD 78 In-stock
Estimated Time of Arrival: December 31
50 mg USD 133 In-stock
Estimated Time of Arrival: December 31
100 mg USD 226 In-stock
Estimated Time of Arrival: December 31
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Description

Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) is a PROTAC linker, which refers to the PEG composition. Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) can be used in the synthesis of a series of PROTACs, such as BI-3663 (HY-111546). BI-3663 is a highly selective PTK2/FAK PROTAC, with cereblon ligands to hijack E3 ligases for PTK2 degradation, and inhibits PTK2 with an IC50 of 18 nM[1].

IC50 & Target

PEGs

 

Molecular Weight

432.53

Formula

C₂₀H₃₂O₈S

CAS No.

217817-01-1

SMILES

O=C(OC(C)(C)C)CCOCCOCCOCCOS(=O)(C1=CC=C(C)C=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Pure form -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
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Keywords:

Tos-PEG4-t-butyl esterTos-PEG4-BocPROTAC LinkerPROTACPEGlinkerBI-3663Inhibitorinhibitorinhibit

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Product name:
Tos-PEG4-t-butyl ester
Cat. No.:
HY-130422
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