1. Protein Tyrosine Kinase/RTK
    PROTAC
  2. FAK
    PROTAC
  3. BI-3663

BI-3663 

Cat. No.: HY-111546
Handling Instructions

BI-3663 is a highly selective PTK2/FAK PROTAC, with VHL and cereblon ligands to hijack E3 ligases for PTK2 degradation. BI-3663 inhibits PTK2 with an IC50 of 18 nM. Anti-cancer activity.

For research use only. We do not sell to patients.

BI-3663 Chemical Structure

BI-3663 Chemical Structure

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Description

BI-3663 is a highly selective PTK2/FAK PROTAC, with VHL and cereblon ligands to hijack E3 ligases for PTK2 degradation. BI-3663 inhibits PTK2 with an IC50 of 18 nM. Anti-cancer activity[1].

IC50 & Target

IC50: 18 nM (PTK2)[1]

In Vitro

BI-3663 potently degrades PTK2 in Hep3B2.1-7 cells, and A549 cells, with pDC50s of 7.6 and 7.9, respectively[1].

References
Molecular Weight

917.84

Formula

C₄₄H₄₂F₃N₇O₁₂

SMILES

O=C(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CCOCCOCCOCCNC(C4=CC=C(NC5=NC=C(C(F)(F)F)C(OC6=CC=CC(CC7)=C6C7=O)=N5)C(OC)=C4)=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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C1   V1   C2   V2

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Product Name:
BI-3663
Cat. No.:
HY-111546
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BI-3663

Cat. No.: HY-111546