1. PROTAC
    Antibody-drug Conjugate/ADC Related
  2. PROTAC Linker
    ADC Linker
  3. N3-PEG3-CH2CH2COOH

N3-PEG3-CH2CH2COOH 

Cat. No.: HY-42490
Handling Instructions

N3-PEG3-CH2CH2COOH a PEG-based PROTAC linker can be used in the synthesis of BI-3663 (HY-111546), BI-4216 and BI-0319. Azido-PEG3-acid is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

N3-PEG3-CH2CH2COOH Chemical Structure

N3-PEG3-CH2CH2COOH Chemical Structure

CAS No. : 1056024-94-2

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Description

N3-PEG3-CH2CH2COOH a PEG-based PROTAC linker can be used in the synthesis of BI-3663 (HY-111546), BI-4216 and BI-0319. Azido-PEG3-acid is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

IC50 & Target

PEGs

 

Non-cleavable

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

247.25

Formula

C₉H₁₇N₃O₅

CAS No.

1056024-94-2

SMILES

O=C(O)CCOCCOCCOCCN=[N+]=[N-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

N3-PEG3-CH2CH2COOHPROTAC LinkerADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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Product Name:
N3-PEG3-CH2CH2COOH
Cat. No.:
HY-42490
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