217817-01-1
Chemical Structure
Tos-PEG4-t-butyl ester
Synonym(s): Tos-PEG4-Boc
- CAS No.: 217817-01-1
- Formula:C20H32O8S
- Molecular Weight:432.53
IUPAC Name: tert-butyl 3-(2-(2-(2-(tosyloxy)ethoxy)ethoxy)ethoxy)propanoate
InChIKey: AAQWIVKRAHBPDM-UHFFFAOYSA-N
SMILES: O=C(OC(C)(C)C)CCOCCOCCOCCOS(=O)(C1=CC=C(C)C=C1)=O
Biological Activity: Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) is a PROTAC linker, which refers to the PEG composition. Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) can be used in the synthesis of a series of PROTACs, such as BI-3663 (HY-111546). BI-3663 is a highly selective PTK2/FAK PROTAC, with cereblon ligands to hijack E3 ligases for PTK2 degradation, and inhibits PTK2 with an IC50 of 18 nM[1].
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Tos-PEG4-t-butyl ester | Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) is a PROTAC linker, which refers to the PEG composition. Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) can be used in the synthesis of a series of PROTACs, such as BI-3663 (HY-111546). BI-3663 is a highly selective PTK2/FAK PROTAC, with cereblon ligands to hijack E3 ligases for PTK2 degradation, and inhibits PTK2 with an IC50 of 18 nM. | |||||||||||||||||||||
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Keywords
