PXN - paxillin Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5829

About PXN

Cytogenetic location: 12q24.23 Genomic coordinates (GRCh38): 12:120,210,447-120,265,730 (from NCBI)

This gene has 22 transcripts (splice variants), 251 orthologues and 2 paralogues. Ubiquitous expression in placenta (RPKM 24.8), fat (RPKM 20.4) and 25 other tissues.

Summary

This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445). [provided by RefSeq, Aug 2011]

PXN Products (15)

mRNA	Protein	Name
NM_001080855.3	NP_001074324.1	paxillin isoform 2
NM_001243756.2	NP_001230685.1	paxillin isoform 3
NM_001385981.1	NP_001372910.1	paxillin isoform 5
NM_001385982.1	NP_001372911.1	paxillin isoform 6
NM_001385983.1	NP_001372912.1	paxillin isoform 7
NM_001385984.1	NP_001372913.1	paxillin isoform 8
NM_001385985.1	NP_001372914.1	paxillin isoform 9
NM_001385986.1	NP_001372915.1	paxillin isoform 10
NM_001385987.1	NP_001372916.1	paxillin isoform 11
NM_001385988.1	NP_001372917.1	paxillin isoform 12
NM_001385989.1	NP_001372918.1	paxillin isoform 13
NM_001385990.1	NP_001372919.1	paxillin isoform 14
NM_001410986.1	NP_001397915.1	paxillin isoform 15
NM_002859.4	NP_002850.2	paxillin isoform 1
NM_025157.5	NP_079433.3	paxillin isoform 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables beta-catenin binding	IPI IPI: Inferred from physical interaction	17513457	GOA
enables neuropilin binding	IPI IPI: Inferred from physical interaction	24863063	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7561682	GOA
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	28759036	GOA
enables vinculin binding	IPI IPI: Inferred from physical interaction	9054445	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cell migration	IMP IMP: Inferred from mutant phenotype	23275153	GOA
involved in cellular response to reactive oxygen species	IEP IEP: Inferred from expression pattern	12686598	GOA
involved in endothelial cell migration	IMP IMP: Inferred from mutant phenotype	24863063	GOA
involved in growth hormone receptor signaling pathway	IDA IDA: Inferred from direct assay	10925297	GOA
involved in positive regulation of stress fiber assembly	IMP IMP: Inferred from mutant phenotype	24863063	GOA
involved in transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	24036928	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell-cell junction	IMP IMP: Inferred from mutant phenotype	25753039	GOA
located in focal adhesion	IDA IDA: Inferred from direct assay	12686598	GOA
located in focal adhesion	IMP IMP: Inferred from mutant phenotype	25705373	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	12686598	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	17449030	GOA
located in stress fiber	IDA IDA: Inferred from direct assay	24036928	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PXN Protein Structure

Paxillin

LIM

0
100
200
300
400
500
591 a.a.

Protein Preferred Names	Protein Names
paxillin	testicular tissue protein Li 134

PXN Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PXN	P49023	GIT2	Homo sapiens	Q14161	Pull Down	22728435
Intra	PXN	P49023	GIT2	Homo sapiens	Q14161	Anti Tag CoIP	31980649
Intra	PXN	P49023	CSK	Homo sapiens	P41240	Anti Bait CoIP	14665621
Intra	PXN	P49023	PTPN12	Homo sapiens	Q05209	Anti Tag CoIP	35271311
Intra	PXN	P49023	PTPN11	Homo sapiens	Q06124	Anti Bait CoIP	14665621
Intra	PXN	P49023	PTPN11	Homo sapiens	Q06124	PLA	23397142
Intra	PXN	P49023	RNF5	Homo sapiens	Q99942	Pull Down	12861019
Intra	PXN	P49023	RNF5	Homo sapiens	Q99942	Anti Tag CoIP	12861019
Intra	PXN	P49023	RNF5	Homo sapiens	Q99942	Anti Bait CoIP	12861019
Intra	PXN	P49023	GIT1	Homo sapiens	Q9Y2X7	Anti Tag CoIP	31980649
Intra	PXN	P49023	GIT1	Homo sapiens	Q9Y2X7	Anti Bait CoIP	16628223
Intra	PXN	P49023	CTNNB1	Homo sapiens	P35222	Pull Down	22728435
Intra	PXN	P49023	GAB1	Homo sapiens	Q13480	Anti Tag CoIP	14665621
Intra	PXN	P49023	PTK2	Homo sapiens	Q05397	Confocal	21034468
Intra	PXN	P49023	PTK2	Homo sapiens	Q05397	Anti Tag CoIP	31980649
Intra	PXN	P49023	PTK2	Homo sapiens	Q05397	Pull Down	9756887
Intra	PXN	P49023	PTK2	Homo sapiens	Q05397	Anti Bait CoIP	25795725
Intra	PXN	P49023	PTK2	Homo sapiens	Q05397	IF	22270917
Intra	PXN	P49023	PTK2	Homo sapiens	Q05397	Anti Bait CoIP	21741599
Intra	PXN	P49023	PTK2	Homo sapiens	Q05397	Anti Bait CoIP	7561682
Intra	PXN	P49023	PTK2	Homo sapiens	Q05397	Pull Down	22270917
Intra	PXN	P49023	ITGA4	Homo sapiens	P13612	Anti Bait CoIP	10604475
Intra	PXN	P49023	ITGA4	Homo sapiens	P13612	Affinity Chrom	10604475
Cross	PXN	P49023	Sorbs1	Mus musculus	Q62417-2	Anti Tag CoIP	17082770
Cross	PXN	P49023	Sorbs1	Mus musculus	Q62417-2	Imaging	17082770
Cross	PXN	P49023	E6	Bovine papillomavirus	P06931	Pull Down	10814581
Cross	PXN	P49023	rnf-5	Caenorhabditis elegans	Q09463	Pull Down	12861019

Cross: Cross-species interaction Intra: Intraspecies interaction

PXN Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80266	Paxillin Antibody (YA243)	WB, ICC/IF, IHC-P, IP	Human, Mouse
HY-P83338	Phospho-Paxillin (Tyr118) Antibody (YA3083)	WB	Human, Mouse, Rat
HY-P86204	Phospho-Paxillin(Tyr118) Antibody (YA5896)	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
HY-P86469	Paxillin Antibody (YA6161)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Acoustic Neuroma	Neurofibromatosis Type 2 Vestibular Schwannoma Acoustic Neurinoma Bilateral Acoustic Neurofibromatosis Nf2 Acoustic Neurilemoma Cerebellopontine Angle Tumor Neurofibromatosis Central Type Neurofibromatosis Type Ii Vestibular Neurilemmoma Acoustic Tumor Neurinoma Of The Acoustic Nerve Acoustic Neurinoma Bilateral Acoustic Schwannomas Bilateral Banf Central Neurofibromatosis Familial Acoustic Neuromas Neurofibromatosis 2 Neurofibromatosis Type 2 Merlin Schwannoma, Acoustic, Bilateral Neuroma Acoustic Neuroma, Acoustic Familial Acoustic Neuroma Familial Vestibular Schwannoma Neurofibromatosis, Central Type Nf2 - [Neurofibromatosis Type 2]
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Colon Adenocarcinoma	Adenocarcinoma Of Colon Adenocarcinoma Of The Colon Colonic Adenocarcinoma
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Petrous Apex Meningioma	Meningioma Of The Petrous Ridge
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11479	PXDN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11484	PXN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17322	Pxn Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23777	Pxn Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PXN	VGNC	VGNC:107261
Canis familiaris	PXN	VGNC	VGNC:52959
Mus musculus	PXN	MGD	MGI:108295
Felis catus	PXN	VGNC	VGNC:80471
Rattus norvegicus	PXN	RGD	RGD:1305759
Macaca mulatta	PXN	VGNC	VGNC:76629
Others	PXN	NCBI