CX-5011 free base
CX-5011 free base is a potent CK2 inhibitor. CX-5011 free base also is a Rac-1 activator. CX-5011 free base induces methuosis and promotes macropinocytosis. CX-5011 free base induces apoptosis. CX-5011 free base decreases the expression of rpS6 phosphorylation.
For research use only. We do not sell to patients.
- CAS No.: 1009821-06-0
- Formula: C20H12N4O2
- Molecular Weight:340.33
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Rac-1[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BXPC-3 | EC50 |
0.27 μM
Compound: 7e
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Inhibition of CK2 in human BxPC3 cells assessed as reduction of Akt phosphorylation at Ser129
Inhibition of CK2 in human BxPC3 cells assessed as reduction of Akt phosphorylation at Ser129
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[PMID: 21316963] |
Chemical Information
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CAS No. 1009821-06-0
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Molecular Weight 340.33
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Formula C20H12N4O2
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SMILES
C#CC1=CC(NC2=NC3=CC(C(O)=O)=CC=C3C4=CN=CN=C42)=CC=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. D'Amore C, et al. "Janus" efficacy of CX-5011: CK2 inhibition and methuosis induction by independent mechanisms. Biochim Biophys Acta Mol Cell Res. 2020 Nov;1867(11):118807. [Content Brief]
[2]. Salizzato V, et al. Inhibition of protein kinase CK2 by CX-5011 counteracts imatinib-resistance preventing rpS6 phosphorylation in chronic myeloid leukaemia cells: new combined therapeutic strategies. Oncotarget. 2016 Apr 5;7(14):18204-18. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CX-5011 free base Related Classifications
HY-50733 Related Classifications
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