1009821-06-0
1009821-06-0
Chemical Structure
CX-5011 free base
- CAS No.: 1009821-06-0
- Formula:C20H12N4O2
- Molecular Weight:340.33
IUPAC Name: 5-((3-ethynylphenyl)amino)pyrimido[4,5-c]quinoline-8-carboxylic acid
InChIKey: HJGFPNFAFSFDNN-UHFFFAOYSA-N
SMILES: C#CC1=CC(NC2=NC3=CC(C(O)=O)=CC=C3C4=CN=CN=C42)=CC=C1
Biological Activity: CX-5011 free base is a potent CK2 inhibitor. CX-5011 free base also is a Rac-1 activator. CX-5011 free base induces methuosis and promotes macropinocytosis. CX-5011 free base induces apoptosis. CX-5011 free base decreases the expression of rpS6 phosphorylation[1][2].
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CX-5011 free base | CX-5011 free base is a potent CK2 inhibitor. CX-5011 free base also is a Rac-1 activator. CX-5011 free base induces methuosis and promotes macropinocytosis. CX-5011 free base induces apoptosis. CX-5011 free base decreases the expression of rpS6 phosphorylation. | |||||||||||||||||||||
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References
- [1]. D'Amore C, et al. "Janus" efficacy of CX-5011: CK2 inhibition and methuosis induction by independent mechanisms. Biochim Biophys Acta Mol Cell Res. 2020 Nov;1867(11):118807. [Content Brief]
- [2]. Salizzato V, et al. Inhibition of protein kinase CK2 by CX-5011 counteracts imatinib-resistance preventing rpS6 phosphorylation in chronic myeloid leukaemia cells: new combined therapeutic strategies. Oncotarget. 2016 Apr 5;7(14):18204-18. [Content Brief]
Keywords
