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GIT1 - GIT ArfGAP 1 Gene

Also Known as p95-APP1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 28964

About GIT1

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:29,573,475-29,589,648 (from NCBI)

This gene has 15 transcripts (splice variants), 198 orthologues and 28 paralogues. Broad expression in testis (RPKM 58.9), brain (RPKM 28.4) and 23 other tissues.

Summary

Enables gamma-tubulin binding activity. Involved in positive regulation of microtubule nucleation and regulation of cytokinesis. Located in several cellular components, including focal adhesion; microtubule cytoskeleton; and mitochondrion. Implicated in attention deficit hyperactivity disorder. Biomarker of Huntington's disease. [provided by Alliance of Genome Resources, Apr 2022]

GIT1 Products (2)

mRNA	Protein	Name
NM_001085454.2	NP_001078923.1	ARF GTPase-activating protein GIT1 isoform 1
NM_014030.4	NP_054749.2	ARF GTPase-activating protein GIT1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables gamma-tubulin binding	IDA IDA: Inferred from direct assay	27012601	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15182672	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of microtubule nucleation	IMP IMP: Inferred from mutant phenotype	27012601	GOA
involved in regulation of cytokinesis	IDA IDA: Inferred from direct assay	23108400	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in centrosome	IDA IDA: Inferred from direct assay	27012601	GOA
located in mitotic spindle pole	IDA IDA: Inferred from direct assay	27012601	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GIT1 Protein Structure

ArfGap

Ank_2

GIT_SHD

GIT1_C

0
200
400
600
761 a.a.

Protein Preferred Names	Protein Names
ARF GTPase-activating protein GIT1	ARF GAP GIT1

GIT1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GIT1	Q9Y2X7	PAK1	Homo sapiens	Q13153	Anti Bait CoIP	16628223
Intra	GIT1	Q9Y2X7	ARHGEF6	Homo sapiens	Q15052	Y2H	21900206
Intra	GIT1	Q9Y2X7	PFDN1	Homo sapiens	O60925	Y2H	21900206
Intra	GIT1	Q9Y2X7	GRK2	Homo sapiens	P25098	Anti Bait CoIP	18369319
Intra	GIT1	Q9Y2X7	GRK2	Homo sapiens	P25098	IF	18369319
Intra	GIT1	Q9Y2X7	GRB2	Homo sapiens	P62993	Y2H	21900206
Intra	GIT1	Q9Y2X7	HTT	Homo sapiens	P42858	Imaging	15383276
Intra	GIT1	Q9Y2X7	HTT	Homo sapiens	P42858	Pull Down	15383276
Intra	GIT1	Q9Y2X7	HTT	Homo sapiens	P42858	CoIP	15383276
Intra	GIT1	Q9Y2X7	HTT	Homo sapiens	P42858	Y2H	15383276
Intra	GIT1	Q9Y2X7	CEP126	Homo sapiens	Q9P2H0	Pull Down	15383276
Intra	GIT1	Q9Y2X7	CEP126	Homo sapiens	Q9P2H0	Y2H	15383276
Intra	GIT1	Q9Y2X7	LRIF1	Homo sapiens	Q5T3J3	Y2H	15383276
Intra	GIT1	Q9Y2X7	LRIF1	Homo sapiens	Q5T3J3	Pull Down	15383276
Intra	GIT1	Q9Y2X7	ARHGEF7	Homo sapiens	Q14155	Anti Tag CoIP	16787945
Cross	GIT1	Q9Y2X7	PXN	Gallus gallus	P49024	Anti Tag CoIP	16717130

Cross: Cross-species interaction Intra: Intraspecies interaction

GIT1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82000	GIT1 Antibody (YA1745)	WB, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity
Progressive Myoclonus Epilepsy 7	Epm7 Meak Myoclonus Epilepsy And Ataxia Due To Potassium Channel Mutation Pme Type 7 Progressive Myoclonic Epilepsy Due To Kv3.1 Deficiency Progressive Myoclonus Epilepsy Type 7
Blind Loop Syndrome	Bacterial Overgrowth Syndrome
Pneumatosis Cystoides Intestinalis
Non-Syndromic X-Linked Intellectual Disability	X-Linked Non-Syndromic Intellectual Disability Non-Specific X-Linked Mental Retardation X-Linked Non-Specific Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-152095	PPI-GIT1/β-Pix PPI-IN-1	Inhibitor	99.01%	Unkown
HY-181978	GIT1-IN-1		/	Unkown
HY-RS05438	GIT1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19605	Git1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26101	Git1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GIT1	VGNC	VGNC:62560
Macaca mulatta	GIT1	VGNC	VGNC:73053
Mus musculus	GIT1	MGD	MGI:1927140
Canis familiaris	GIT1	VGNC	VGNC:41229
Rattus norvegicus	GIT1	RGD	RGD:69331
Bos taurus	GIT1	VGNC	VGNC:29368
Others	GIT1	NCBI