2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. PPI-GIT1/β-Pix interaction-IN-1

PPI-GIT1/β-Pix interaction-IN-1 is a potent and orally active GIT1/β-Pix protein-protein interaction (PPI) inhibitor with a KD value of 7.7 µM. PPI-GIT1/β-Pix interaction-IN-1 disrupts the GIT/PIX interaction can impact the activation of the downstream Rho GTPase Rac1 and Cdc42. PPI-GIT1/β-Pix interaction-IN-1 inhibits metastasis of gastric cancer.

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PPI-GIT1/β-Pix interaction-IN-1 Chemical Structure

PPI-GIT1/β-Pix interaction-IN-1 Chemical Structure

CAS No. : 2070916-70-8

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PPI-GIT1/β-Pix interaction-IN-1 Related Antibodies

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Description

PPI-GIT1/β-Pix interaction-IN-1 is a potent and orally active GIT1/β-Pix protein-protein interaction (PPI) inhibitor with a KD value of 7.7 µM. PPI-GIT1/β-Pix interaction-IN-1 disrupts the GIT/PIX interaction can impact the activation of the downstream Rho GTPase Rac1 and Cdc42. PPI-GIT1/β-Pix interaction-IN-1 inhibits metastasis of gastric cancer[1].

In Vitro

PPI-GIT1/β-Pix interaction-IN-1 (compound 14-5-18; 0-50 μM) inhibits the interaction between GIT1 and β-Pix in living cells[1].
PPI-GIT1/β-Pix interaction-IN-1 (0-50 μM; 24 h; MGC803 cells and MKN45 cells) inhibits gastric cancer cell invasion in a dose-dependent manner and disrupts the GIT/PIX interaction can impact the activation of the downstream Rho GTPase Rac1 and Cdc42[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PPI-GIT1/β-Pix interaction-IN-1 Related Antibodies

Western Blot Analysis[1]

Cell Line: MGC803 cells and MKN45 cells
Concentration: 0, 5, 20, and 50 μM
Incubation Time: 24 hours
Result: Suppressed the expression of GTP-Rac1 and GTP-Cdc42 in a dose-dependent manner.
In Vivo

PPI-GIT1/β-Pix interaction-IN-1 (compound 14-5-18; 10 and 30 mg/kg; i.g.; 24 h) inhibits gastric cancer cell invasion in female nude mice with MGC803 xenografts[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female nude mice with MGC803 xenografts (Four-week-old)[1]
Dosage: 10 and 30 mg/kg
Administration: oral gavage, daily, for 18 days
Result: Reduced the luminescence intensity in the lungs in a dose-dependent manner.
Molecular Weight

391.42

Formula

C23H21NO5
CAS No.
SMILES

O=C([C@@H]1[C@@H](C(OCC)=O)[C@]2(C(N(C)C3=C2C=CC=C3)=O)[C@H]/4C1)C4=C\C5=COC=C5
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
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References
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PPI-GIT1/β-Pix interaction-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PPI-GIT1/β-Pix interaction-IN-12070916-70-8Rasprotein-protein interactionRho GTPase Rac1Cdc42gastric cancerMGC803MKN45Inhibitorinhibitorinhibit

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