LRIF1 - ligand dependent nuclear receptor interacting factor 1 Gene

Also Known as RIF1; FSHD3; HBiX1; C1orf103

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55791

About LRIF1

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:110,874,957-110,963,922 (from NCBI)

This gene has 3 transcripts (splice variants), 170 orthologues and is associated with 1 phenotype. Broad expression in testis (RPKM 11.6), ovary (RPKM 5.5) and 24 other tissues.

Summary

Predicted to enable retinoic acid receptor binding activity. Involved in dosage compensation by inactivation of X chromosome. Located in Barr body; centriolar satellite; and nucleoplasm. Colocalizes with chromosome, telomeric region. [provided by Alliance of Genome Resources, Apr 2022]

LRIF1 Products (2)

mRNA Protein Name
NM_001006945.2 NP_001006946.1 ligand-dependent nuclear receptor-interacting factor 1 isoform 2
NM_018372.4 NP_060842.3 ligand-dependent nuclear receptor-interacting factor 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15383276 GOA
Biological Process GO Annotation Evidence References Source
involved in dosage compensation by inactivation of X chromosome IMP
IMP: Inferred from mutant phenotype
23542155 GOA
Cellular Component GO Annotation Evidence References Source
located in Barr body IDA
IDA: Inferred from direct assay
23542155 GOA
colocalizes with chromosome, telomeric region IDA
IDA: Inferred from direct assay
24270157 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ligand-dependent nuclear receptor-interacting factor 1

  • HP1-binding protein enriched in inactive X chromosome protein 1

LRIF1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LRIF1 Q5T3J3 ZBTB14 Homo sapiens O43829
Y2H Array
32814053
Intra
LRIF1 Q5T3J3 ZBTB14 Homo sapiens O43829
Y2H Pooling
32814053
Intra
LRIF1 Q5T3J3 ZBTB14 Homo sapiens O43829
Validated Y2H
32814053
Intra
LRIF1 Q5T3J3 SPATA18 Homo sapiens Q8TC71
Validated Y2H
32296183
Intra
LRIF1 Q5T3J3 BANP Homo sapiens Q8N9N5-2
Y2H Array
32296183
Intra
LRIF1 Q5T3J3 BANP Homo sapiens Q8N9N5-2
Y2H Prey Pooling
32296183
Intra
LRIF1 Q5T3J3 BANP Homo sapiens Q8N9N5-2
Validated Y2H
32296183
Intra
LRIF1 Q5T3J3 ZNF410 Homo sapiens Q86VK4-3
Validated Y2H
32296183
Intra
LRIF1 Q5T3J3 SLC3A2 Homo sapiens P08195-4
Y2H Array
32814053
Intra
LRIF1 Q5T3J3 SLC3A2 Homo sapiens P08195-4
Y2H Pooling
32814053
Intra
LRIF1 Q5T3J3 SLC3A2 Homo sapiens P08195-4
Validated Y2H
32814053
Intra
LRIF1 Q5T3J3 SMCHD1 Homo sapiens A6NHR9
Anti Bait CoIP
23542155
Intra
LRIF1 Q5T3J3 SMCHD1 Homo sapiens A6NHR9
Anti Tag CoIP
26496610
Intra
LRIF1 Q5T3J3 SMCHD1 Homo sapiens A6NHR9
Anti Tag CoIP
23542155
Intra
LRIF1 Q5T3J3 TSEN15 Homo sapiens Q8WW01
Validated Y2H
32296183
Intra
LRIF1 Q5T3J3 FOXD4L6 Homo sapiens Q3SYB3
Validated Y2H
32814053
Intra
LRIF1 Q5T3J3 FOXD4L6 Homo sapiens Q3SYB3
Y2H Array
32814053
Intra
LRIF1 Q5T3J3 FOXD4L6 Homo sapiens Q3SYB3
Y2H Pooling
32814053
Intra
LRIF1 Q5T3J3 VSX2 Homo sapiens P58304
Validated Y2H
32814053
Intra
LRIF1 Q5T3J3 VSX2 Homo sapiens P58304
Y2H Array
32814053
Intra
LRIF1 Q5T3J3 VSX2 Homo sapiens P58304
Y2H Pooling
32814053
Intra
LRIF1 Q5T3J3 CRACR2A Homo sapiens Q9BSW2
Validated Y2H
32296183
Intra
LRIF1 Q5T3J3 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Intra
LRIF1 Q5T3J3 CBX3 Homo sapiens Q13185
Y2H Prey Pooling
32296183
Intra
LRIF1 Q5T3J3 CBX3 Homo sapiens Q13185
Y2H Array
32296183
Intra
LRIF1 Q5T3J3 CBX3 Homo sapiens Q13185
Anti Tag CoIP
23542155
Intra
LRIF1 Q5T3J3 CBX5 Homo sapiens P45973
Anti Tag CoIP
23542155
Intra
LRIF1 Q5T3J3 CBX5 Homo sapiens P45973
Y2H
23542155
Intra
LRIF1 Q5T3J3 CBX5 Homo sapiens P45973
Y2H
21900206
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Facioscapulohumeral Muscular Dystrophy 3, Digenic

  • FSHD3
Facioscapulohumeral Muscular Dystrophy 2, Digenic

  • Facioscapulohumeral Muscular Dystrophy 2

  • FSHD2

  • Fshd1b

  • Facioscapulohumeral Muscular Dystrophy 1b

  • Fshd2, Digenic

  • Muscular Dystrophy, Facioscapulohumeral, Type 2

  • Muscular Dystrophy, Facioscapulohumeral, Type 1b

  • Fascioscapulohumeral Muscular Dystrophy 2, Digenic

  • Facioscapulohumeral Muscular Dystrophy Type 2

  • Digenic Facioscapulohumeral Muscular Dystrophy

  • Digenic Fshd2

  • Facioscapulohumeral Muscular Dystrophy Type 1b

  • Dystrophy, Muscular, Facioscapulohumeral, Type 2
Facioscapulohumeral Muscular Dystrophy 1

  • Facioscapulohumeral Muscular Dystrophy

  • Fshd

  • Landouzy-Dejerine Muscular Dystrophy

  • Muscular Dystrophy, Facioscapulohumeral

  • FSHD1

  • Fshd1a

  • Muscular Dystrophy, Facioscapulohumeral, Type 1a

  • Facioscapulohumeral Muscular Dystrophy Type 1a

  • Fsh Muscular Dystrophy

  • Facioscapulohumeral Muscular Dystrophy 1a

  • Facioscapulohumeral Atrophy

  • Facioscapulohumeral Myopathy

  • Muscular Dystrophy, Facioscapulohumeral, Type 1

  • Facioscapulohumeral Muscular Dystrophy Type 1

  • Landouzy Dejerine Muscular Dystrophy

  • Muscular Dystrophy, Landouzy-Dejerine

  • Fshmd1a

  • Facio-Scapulo-Humeral Dystrophy

  • Facioscapulohumeral Type Progressive Muscular Dystrophy

  • Facioscapuloperoneal Muscular Dystrophy

  • Facioscapulohumeral Dystrophy

  • Fsh Dystrophy

  • Landouzy-Dejerine Dystrophy

  • Landouzy-Dejerine Myopathy

  • Fmd

  • Facioscapulohumeral Muscular Dystrophy-1a

  • Muscular Dystrophy Facioscapulohumeral

  • Dystrophy, Muscular, Facioscapulohumeral

  • Dystrophy, Muscular, Facioscapulohumeral, Type 1

  • Landouzy-Dejerine Disease

  • Landouzy-Déjerine Atrophy

  • Facioscapulohumeral Muscle Dystrophy

  • Fmd - [Facioscapulohumeral Muscular Dystrophy]

  • Fsh - [Facioscapulohumeral Muscular Dystrophy]

  • Fshd - [Facioscapulohumeral Muscular Dystrophy]

  • Landouzy-Déjerine Dystrophy Or Facioscapulohumeral Atrophy

  • Landouzy-Déjérine Muscular Dystrophy
Digenic Disease
Muscular Dystrophy

  • Muscular Dystrophies

  • Congenital Md

  • Congenital Muscular Dystrophy

  • Cmd

  • Mdc

  • Dystrophy, Muscular

  • Gower'S Muscular Dystrophy

  • Progressive Musclular Dystrophy

  • Pseudohypertrophic Atrophy

  • Pseudohypertrophic Muscle Paralysis

  • Pseudohypertrophic Muscular Atrophy

  • Pseudohypertrophic Muscular Dystrophy

  • Pseudohypertrophic Paralysis

  • Pseudomuscular Hypertrophy
Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome

  • Icf Syndrome

  • Immunodeficiency Syndrome, Variable

  • Ciid

  • Centromeric Instability, Immunodeficiency Syndrome

  • Immune Deficiency, Variable, With Centromeric Instability Of Chromosomes 1, 9, And 16

  • Icf
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07786 LRIF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus LRIF1 MGD MGI:2445214
Bos taurus LRIF1 VGNC VGNC:30981
Rattus norvegicus LRIF1 RGD RGD:1306520
Felis catus LRIF1 VGNC VGNC:63280
Macaca mulatta LRIF1 VGNC VGNC:74406
Canis familiaris LRIF1 VGNC VGNC:42766
Others LRIF1 NCBI