CRACR2A - calcium release activated channel regulator 2A Gene

Homo sapiens

Also known as RAB46; EFCAB4B

Gene ID: 84766 | Gene type: protein coding

About CRACR2A

Cytogenetic location: 12p13.32 Genomic coordinates (GRCh38): 12:3,615,328-3,753,109 (from NCBI)

This gene has 6 transcripts (splice variants), 268 orthologues and 1 paralogue. Broad expression in salivary gland (RPKM 9.7), colon (RPKM 7.2) and 16 other tissues.

Summary

Enables GTPase activity and calcium ion binding activity. Involved in several processes, including activation of store-operated Calcium Channel activity; positive regulation of JNK cascade; and store-operated calcium entry. Located in several cellular components, including Golgi apparatus; Weibel-Palade body; and immunological synapse. [provided by Alliance of Genome Resources, Apr 2022]

CRACR2A Products(2)

mRNA	Protein	Name
NM_001144958.2	NP_001138430.1	EF-hand calcium-binding domain-containing protein 4B isoform a
NM_032680.4	NP_116069.1	EF-hand calcium-binding domain-containing protein 4B isoform c

CRACR2A Protein Structure

EF-hand_8

0
100
200
300
395 a.a.

Protein Preferred Names

Protein Names

EF-hand calcium-binding domain-containing protein 4B

CRAC channel regulator 2A

Related Diseases

Diseases

Alias

Mucinous Stomach Adenocarcinoma

Mucinous Adenocarcinoma Of The Stomach

Mucinous Gastric Adenocarcinoma

Stormorken Syndrome

Thrombocytopathy, Asplenia, And Miosis	Stormorken-Sjaastad-Langslet Syndrome
STRMK	York Platelet Syndrome
Yps	Thrombocytopathy, Asplenia And Miosis
Thrombocytopathy Asplenia Miosis	Thrombocytopathy-Asplenia-Miosis Syndrome
Miosis Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03137	CRACR2A Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CRACR2A	RGD	RGD:1563719
Felis catus	CRACR2A	VGNC	VGNC:61157
Mus musculus	CRACR2A	MGD	MGI:2685919
Canis familiaris	CRACR2A	VGNC	VGNC:39589

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