CRACR2A - calcium release activated channel regulator 2A Gene

Also Known as RAB46; EFCAB4B

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84766

About CRACR2A

Cytogenetic location: 12p13.32 Genomic coordinates (GRCh38): 12:3,615,328-3,753,109 (from NCBI)

This gene has 6 transcripts (splice variants), 268 orthologues and 1 paralogue. Broad expression in salivary gland (RPKM 9.7), colon (RPKM 7.2) and 16 other tissues.

Summary

Enables GTPase activity and calcium ion binding activity. Involved in several processes, including activation of store-operated Calcium Channel activity; positive regulation of JNK cascade; and store-operated calcium entry. Located in several cellular components, including Golgi apparatus; Weibel-Palade body; and immunological synapse. [provided by Alliance of Genome Resources, Apr 2022]

CRACR2A Products (2)

mRNA Protein Name
NM_001144958.2 NP_001138430.1 EF-hand calcium-binding domain-containing protein 4B isoform a
NM_032680.4 NP_116069.1 EF-hand calcium-binding domain-containing protein 4B isoform c

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase activity IMP
IMP: Inferred from mutant phenotype
27016526 GOA
enables calcium ion binding IDA
IDA: Inferred from direct assay
20418871 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20418871 GOA
Biological Process GO Annotation Evidence References Source
involved in T-helper 1 cell differentiation IMP
IMP: Inferred from mutant phenotype
29987160 GOA
involved in activation of store-operated calcium channel activity IMP
IMP: Inferred from mutant phenotype
20418871 GOA
involved in endosomal transport IDA
IDA: Inferred from direct assay
30814157 GOA
involved in positive regulation of JNK cascade IMP
IMP: Inferred from mutant phenotype
27016526 GOA
involved in positive regulation of calcium ion transport IMP
IMP: Inferred from mutant phenotype
20418871 GOA
involved in protein localization IMP
IMP: Inferred from mutant phenotype
20418871 GOA
involved in response to histamine IDA
IDA: Inferred from direct assay
31092558 GOA
involved in store-operated calcium entry IMP
IMP: Inferred from mutant phenotype
20418871 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi membrane IDA
IDA: Inferred from direct assay
27016526 GOA
located in Weibel-Palade body IDA
IDA: Inferred from direct assay
31092558 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
20418871 GOA
located in immunological synapse IDA
IDA: Inferred from direct assay
27016526 GOA
located in microtubule organizing center IDA
IDA: Inferred from direct assay
30814157 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
30814157 GOA
located in trans-Golgi network membrane IDA
IDA: Inferred from direct assay
27016526 GOA
located in vesicle IDA
IDA: Inferred from direct assay
27016526 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CRACR2A Protein Structure

EF-hand_8

EF-hand_8: EF-hand domain pair (67 - 113)

  • 0
  • 100
  • 200
  • 300
  • 395 a.a.
Protein Preferred Names Protein Names

EF-hand calcium-binding domain-containing protein 4B

  • CRAC channel regulator 2A

CRACR2A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CRACR2A Q9BSW2 PNMA5 Homo sapiens Q96PV4
Y2H Prey Pooling
32296183
Intra
CRACR2A Q9BSW2 PNMA5 Homo sapiens Q96PV4
Y2H Array
32296183
Intra
CRACR2A Q9BSW2 MID2 Homo sapiens Q9UJV3-2
Y2H Prey Pooling
32296183
Intra
CRACR2A Q9BSW2 MID2 Homo sapiens Q9UJV3-2
Validated Y2H
32296183
Intra
CRACR2A Q9BSW2 MID2 Homo sapiens Q9UJV3-2
Y2H Array
32296183
Intra
CRACR2A Q9BSW2 CCHCR1 Homo sapiens Q8TD31-3
Y2H Array
32296183
Intra
CRACR2A Q9BSW2 CCHCR1 Homo sapiens Q8TD31-3
Y2H Prey Pooling
32296183
Intra
CRACR2A Q9BSW2 SLAIN1 Homo sapiens Q8ND83
Y2H Prey Pooling
32296183
Intra
CRACR2A Q9BSW2 SLAIN1 Homo sapiens Q8ND83
Y2H Array
32296183
Intra
CRACR2A Q9BSW2 KRTAP19-5 Homo sapiens Q3LI72
Y2H Array
32296183
Intra
CRACR2A Q9BSW2 KRTAP19-5 Homo sapiens Q3LI72
Y2H Prey Pooling
32296183
Intra
CRACR2A Q9BSW2 DMWD Homo sapiens G5E9A7
Y2H Pooling
32814053
Intra
CRACR2A Q9BSW2 DMWD Homo sapiens G5E9A7
Validated Y2H
32814053
Intra
CRACR2A Q9BSW2 DMWD Homo sapiens G5E9A7
Y2H Array
32814053
Intra
CRACR2A Q9BSW2 TLE5 Homo sapiens Q08117-2
Y2H Array
32296183
Intra
CRACR2A Q9BSW2 TLE5 Homo sapiens Q08117-2
Y2H Prey Pooling
32296183
Intra
CRACR2A Q9BSW2 RBAK Homo sapiens Q9NYW8
Validated Y2H
32296183
Intra
CRACR2A Q9BSW2 RBAK Homo sapiens Q9NYW8
Y2H Array
32296183
Intra
CRACR2A Q9BSW2 RBAK Homo sapiens Q9NYW8
Y2H Prey Pooling
32296183
Intra
CRACR2A Q9BSW2 FAM86C1P Homo sapiens Q9NVL1-2
Validated Y2H
32296183
Intra
CRACR2A Q9BSW2 FAM86C1P Homo sapiens Q9NVL1-2
Y2H Array
32296183
Intra
CRACR2A Q9BSW2 FAM86C1P Homo sapiens Q9NVL1-2
Y2H Prey Pooling
32296183
Intra
CRACR2A Q9BSW2 ZC2HC1C Homo sapiens Q53FD0-2
Y2H Prey Pooling
32296183
Intra
CRACR2A Q9BSW2 ZC2HC1C Homo sapiens Q53FD0-2
Y2H Array
32296183
Intra
CRACR2A Q9BSW2 ASB3 Homo sapiens Q9Y575-3
Validated Y2H
32296183
Intra
CRACR2A Q9BSW2 ASB3 Homo sapiens Q9Y575-3
Y2H Array
32296183
Intra
CRACR2A Q9BSW2 ASB3 Homo sapiens Q9Y575-3
Y2H Prey Pooling
32296183
Intra
CRACR2A Q9BSW2 MCPH1 Homo sapiens Q8NEM0
Anti Tag CoIP
28514442
Intra
CRACR2A Q9BSW2 MCPH1 Homo sapiens Q8NEM0
Anti Tag CoIP
33961781
Intra
CRACR2A Q9BSW2 ANKRD29 Homo sapiens Q8N6D5
Y2H Prey Pooling
32296183
Intra
CRACR2A Q9BSW2 ANKRD29 Homo sapiens Q8N6D5
Y2H Array
32296183
Intra
CRACR2A Q9BSW2 RORB Homo sapiens Q92753-1
Y2H Prey Pooling
32296183
Intra
CRACR2A Q9BSW2 RORB Homo sapiens Q92753-1
Y2H Array
32296183
Intra
CRACR2A Q9BSW2 ORAI1 Homo sapiens Q96D31
Pull Down
20418871
Intra
CRACR2A Q9BSW2 ORAI1 Homo sapiens Q96D31
Anti Tag CoIP
20418871
Intra
CRACR2A Q9BSW2 MKRN3 Homo sapiens Q13064
Validated Y2H
25416956
Intra
CRACR2A Q9BSW2 KRT75 Homo sapiens O95678
Y2H Array
32296183
Intra
CRACR2A Q9BSW2 KRT75 Homo sapiens O95678
Y2H Prey Pooling
32296183
Intra
CRACR2A Q9BSW2 TRAF1 Homo sapiens Q13077
Y2H Array
32296183
Intra
CRACR2A Q9BSW2 TRAF1 Homo sapiens Q13077
Y2H Prey Pooling
32296183
Cross
CRACR2A Q9BSW2 Hoxa1 Mus musculus P09022
Y2H
23088713
Cross
CRACR2A Q9BSW2 Hoxa1 Mus musculus P09022
BiFC
23088713
Cross
CRACR2A Q9BSW2 Hoxa1 Mus musculus P09022
Pull Down
23088713
Intra
CRACR2A Q9BSW2 STIM1 Homo sapiens Q13586
Anti Tag CoIP
20418871
Intra
CRACR2A Q9BSW2 STIM1 Homo sapiens Q13586
Pull Down
20418871
Intra
CRACR2A Q9BSW2 STIM1 Homo sapiens Q13586
IF
20418871
Intra
CRACR2A Q9BSW2 LRIF1 Homo sapiens Q5T3J3
Y2H Array
32296183
Intra
CRACR2A Q9BSW2 LRIF1 Homo sapiens Q5T3J3
Y2H Prey Pooling
32296183
Intra
CRACR2A Q9BSW2 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
CRACR2A Q9BSW2 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
CRACR2A Q9BSW2 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
CRACR2A Q9BSW2 OIP5 Homo sapiens O43482
Y2H Prey Pooling
32296183
Intra
CRACR2A Q9BSW2 OIP5 Homo sapiens O43482
Y2H Array
32296183
Intra
CRACR2A Q9BSW2 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
CRACR2A Q9BSW2 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
CRACR2A Q9BSW2 ZNF655 Homo sapiens Q8N720
Y2H Prey Pooling
32296183
Intra
CRACR2A Q9BSW2 ZNF655 Homo sapiens Q8N720
Y2H Array
32296183
Intra
CRACR2A Q9BSW2 ZNF20 Homo sapiens P17024
Y2H Array
32296183
Intra
CRACR2A Q9BSW2 ZNF20 Homo sapiens P17024
Y2H Prey Pooling
32296183
Intra
CRACR2A Q9BSW2 TLE5 Homo sapiens Q08117
Validated Y2H
25416956
Intra
CRACR2A Q9BSW2 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra
CRACR2A Q9BSW2 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra
CRACR2A Q9BSW2 SORBS3 Homo sapiens O60504
Y2H Prey Pooling
32296183
Intra
CRACR2A Q9BSW2 SORBS3 Homo sapiens O60504
Y2H Array
32296183
Intra
CRACR2A Q9BSW2 DDIT3 Homo sapiens P35638
Y2H Prey Pooling
32296183
Intra
CRACR2A Q9BSW2 DDIT3 Homo sapiens P35638
Y2H Array
32296183
Intra
CRACR2A Q9BSW2 FKBP6 Homo sapiens O75344
Y2H Array
32296183
Intra
CRACR2A Q9BSW2 FKBP6 Homo sapiens O75344
Y2H Prey Pooling
32296183
Intra
CRACR2A Q9BSW2 FAM156B Homo sapiens Q8NDB6
Y2H Prey Pooling
32296183
Intra
CRACR2A Q9BSW2 FAM156B Homo sapiens Q8NDB6
Y2H Array
32296183
Intra
CRACR2A Q9BSW2 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Prey Pooling
25416956
Intra
CRACR2A Q9BSW2 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
25416956
Intra
CRACR2A Q9BSW2 GIGYF1 Homo sapiens O75420
Y2H Array
32296183
Intra
CRACR2A Q9BSW2 GIGYF1 Homo sapiens O75420
Y2H Prey Pooling
32296183
Intra
CRACR2A Q9BSW2 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra
CRACR2A Q9BSW2 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Mucinous Stomach Adenocarcinoma

  • Mucinous Adenocarcinoma Of The Stomach

  • Mucinous Gastric Adenocarcinoma
Stormorken Syndrome

  • Thrombocytopathy, Asplenia, And Miosis

  • Stormorken-Sjaastad-Langslet Syndrome

  • STRMK

  • York Platelet Syndrome

  • Yps

  • Thrombocytopathy, Asplenia And Miosis

  • Thrombocytopathy Asplenia Miosis

  • Thrombocytopathy-Asplenia-Miosis Syndrome

  • Miosis Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03137 CRACR2A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CRACR2A RGD RGD:1563719
Felis catus CRACR2A VGNC VGNC:61157
Mus musculus CRACR2A MGD MGI:2685919
Canis familiaris CRACR2A VGNC VGNC:39589
Others CRACR2A NCBI