ORAI1 - ORAI calcium release-activated calcium modulator 1 Gene

Also Known as IMD9; TAM2; ORAT1; CRACM1; TMEM142A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84876

About ORAI1

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:121,626,550-121,642,040 (from NCBI)

Summary

The protein encoded by this gene is a membrane Calcium Channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011]

ORAI1 Products (1)

mRNA Protein Name
NM_032790.3 NP_116179.2 calcium release-activated calcium channel protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium channel activity IDA
IDA: Inferred from direct assay
31009446 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
18757751 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17360584 GOA
enables store-operated calcium channel activity IDA
IDA: Inferred from direct assay
16645049 GOA
Biological Process GO Annotation Evidence References Source
involved in calcineurin-NFAT signaling cascade IMP
IMP: Inferred from mutant phenotype
33941685 GOA
involved in calcium ion transmembrane transport IDA
IDA: Inferred from direct assay
31009446 GOA
involved in positive regulation of adenylate cyclase activity IDA
IDA: Inferred from direct assay
19171672 GOA
involved in positive regulation of calcium ion transport IDA
IDA: Inferred from direct assay
16645049 GOA
involved in regulation of calcium ion transport IMP
IMP: Inferred from mutant phenotype
16921383 GOA
involved in store-operated calcium entry IDA
IDA: Inferred from direct assay
16921383 GOA
Cellular Component GO Annotation Evidence References Source
located in membrane raft IDA
IDA: Inferred from direct assay
22494970 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
16645049 GOA
located in plasma membrane raft IDA
IDA: Inferred from direct assay
19171672 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ORAI1 Protein Structure

Orai-1

Orai-1: Mediator of CRAC channel activity (70 - 271)

  • 0
  • 100
  • 200
  • 303 a.a.
Protein Preferred Names Protein Names

calcium release-activated calcium channel protein 1

  • calcium release-activated calcium modulator 1

ORAI1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
ORAI1 Q96D31 Trpc6 Mus musculus Q61143
Anti Tag CoIP
17360584
Cross
ORAI1 Q96D31 Trpc6 Mus musculus Q61143
Pull Down
17360584
Intra
ORAI1 Q96D31 STIM1 Homo sapiens Q13586
Pull Down
19249086
Intra
ORAI1 Q96D31 ORAI1 Homo sapiens Q96D31
Crosslink
20018736
Intra
ORAI1 Q96D31 STIM1 Homo sapiens Q13586
Ub Reconstruction
19249086
Intra
ORAI1 Q96D31 STIM1 Homo sapiens Q13586
Anti Tag CoIP
19249086
Intra
ORAI1 Q96D31 ORAI1 Homo sapiens Q96D31
GMS
19249086
Intra
ORAI1 Q96D31 STIM1 Homo sapiens Q13586
Anti Tag CoIP
19706554
Intra
ORAI1 Q96D31 STIM1 Homo sapiens Q13586
AFM
24996186
Intra
ORAI1 Q96D31 ORAI1 Homo sapiens Q96D31
FRET
18757751
Intra
ORAI1 Q96D31 STIM1 Homo sapiens Q13586
GMS
19249086
Intra
ORAI1 Q96D31 STIM1 Homo sapiens Q13586
Anti Tag CoIP
20418871
Intra
ORAI1 Q96D31 EFHB Homo sapiens Q8N7U6
Anti Bait CoIP
30481768
Intra
ORAI1 Q96D31 ATP2C2 Homo sapiens O75185
Confocal
20887894
Intra
ORAI1 Q96D31 ATP2C2 Homo sapiens O75185
Anti Bait CoIP
20887894
Intra
ORAI1 Q96D31 ATP2C2 Homo sapiens O75185
Pull Down
20887894
Intra
ORAI1 Q96D31 ORAI3 Homo sapiens Q9BRQ5
Confocal
24954132
Intra
ORAI1 Q96D31 ORAI3 Homo sapiens Q9BRQ5
FRET
19887627
Intra
ORAI1 Q96D31 CRACR2A Homo sapiens Q9BSW2
Anti Tag CoIP
20418871
Intra
ORAI1 Q96D31 CRACR2A Homo sapiens Q9BSW2
Pull Down
20418871
Intra
ORAI1 Q96D31 TRPC1 Homo sapiens P48995
Anti Bait CoIP
21408196
Cross: Cross-species interaction Intra: Intraspecies interaction

ORAI1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82768 Orai1 Antibody (YA2513) WB, IP Human, Mouse, Rat
HY-P82768A Orai1 Antibody (YA2513)(PBS only) WB, IP Human, Mouse, Rat
HY-P83412 Orai1 Antibody (YA3157) WB Human

Related Diseases

Diseases Alias
Immunodeficiency 9

  • Immune Dysfunction With T-Cell Inactivation Due To Calcium Entry Defect 1

  • Combined Immunodeficiency Due To Orai1 Deficiency

  • IMD9

  • Cid Due To Orai1 Deficiency

  • Severe Combined Immunodeficiency Due To Crac Channel Dysfunction

  • Immunodeficiency, Type 9
Myopathy, Tubular Aggregate, 2

  • TAM2

  • Tubular Aggregate Myopathy 2
Stormorken Syndrome

  • Thrombocytopathy, Asplenia, And Miosis

  • Stormorken-Sjaastad-Langslet Syndrome

  • STRMK

  • York Platelet Syndrome

  • Yps

  • Thrombocytopathy, Asplenia And Miosis

  • Thrombocytopathy Asplenia Miosis

  • Thrombocytopathy-Asplenia-Miosis Syndrome

  • Miosis Disorder
Myopathy, Tubular Aggregate, 1

  • Tubular Aggregate Myopathy

  • Tam

  • Myopathy With Tubular Aggregates

  • TAM1

  • Myopathy, Tubular Aggregate

  • Tubular Aggregate Myopathy 1
Ectodermal Dysplasia

  • Congenital Ectodermal Defect

  • Congenital Ectodermal Dysplasia

  • Ectodermal Dysplasia Syndrome

  • Dysplasia, Ectodermal
Anhidrosis

  • Hypohidrosis

  • Absence Of Sweating

  • Adiaphoresis

  • Impaired Sweating

  • Oligohidrosis
Immunodeficiency 10

  • Immune Dysfunction With T-Cell Inactivation Due To Calcium Entry Defect 2

  • Combined Immunodeficiency Due To Stim1 Deficiency

  • IMD10

  • Stim1 Deficiency

  • Cid Due To Stim1 Deficiency

  • Immune Dysfunction, With T-Cell Inactivation Due To Calcium Entry Defect 2

  • Immunodeficiency, Type 10
T Cell And Nk Cell Immunodeficiency
Combined Immunodeficiency

  • Combined T Cell And B Cell Immunodeficiency

  • Congenital Combined Immunodeficiency

  • Syndrome With Combined Immunodeficiency

  • Combined T And B Cell Immunodeficiency

  • Combined Immunity Deficiency

  • Combined Immunodeficiency Syndrome

  • Combined T-Cell And B-Cell Immunodeficiency

  • Lymphopenic Agammaglobulinaemia
Urolithiasis
Myopathy

  • Muscular Diseases

  • Myopathies
Severe Combined Immunodeficiency

  • Scid

  • Severe Combined Immunodeficiency Disease

  • Combined T And B Cell Inborn Immunodeficiency

  • Immunodeficiency, Severe Combined

  • Scid - [Severe Combined Immunodeficiencies]
Nephrolithiasis

  • Kidney Stones

  • Stone - Kidney/Ureter

  • Kidney Calculi
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-101942 Zegocractin Inhibitor 99.96% Phase 2

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100001 SKF-96365 (hydrochloride) 99.93% Unkown
HY-19408 Pyr10 Inhibitor 99.95% Unkown
HY-103310 MRS1845 Inhibitor 99.46% Unkown
HY-113618B RO2959 monohydrochloride Inhibitor 98.03% Unkown
HY-12521 GSK-5498A Inhibitor 99.94% Unkown
HY-125942 SKF-96365 99.97% Unkown
HY-113618A RO2959 hydrochloride Inhibitor 99.12% Unkown
HY-RS09822 ORAI1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17989 Orai1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-103071 GSK-5503A Inhibitor / Unkown
HY-RS24460 Orai1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990478 Anti-Orai1 Antibody 99.16% Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ORAI1 VGNC VGNC:44137
Rattus norvegicus ORAI1 RGD RGD:1311873
Mus musculus ORAI1 MGD MGI:1925542
Bos taurus ORAI1 VGNC VGNC:32443
Macaca mulatta ORAI1 VGNC VGNC:75464
Felis catus ORAI1 VGNC VGNC:63971
Others ORAI1 NCBI