1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. Calcium Channel
    CRAC Channel
  3. MRS1845

MRS1845 

Cat. No.: HY-103310 Purity: 98.80%
Handling Instructions

MRS1845 is a selective store-operated calcium (SOC) channel inhibitor with an IC50 of 1.7 μM. MRS1845 is an ORAI1 inhibitor.

For research use only. We do not sell to patients.

MRS1845 Chemical Structure

MRS1845 Chemical Structure

CAS No. : 544478-19-5

Size Price Stock Quantity
10 mg USD 100 In-stock
Estimated Time of Arrival: December 31
25 mg USD 180 In-stock
Estimated Time of Arrival: December 31
50 mg USD 280 In-stock
Estimated Time of Arrival: December 31
100 mg USD 420 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

MRS1845 is a selective store-operated calcium (SOC) channel inhibitor with an IC50 of 1.7 μM[1]. MRS1845 is an ORAI1 inhibitor[2][3].

IC50 & Target

Ca2+ channel[1]

In Vitro

Treatment with MRS1845 (10 μM) virtually disrupts the effects of β-glycerophosphate on store-operated Ca2+ entry (SOCE)[2].
MRS1845 (10 μM) significantly decreases SOCE and virtually abolishes the increase of SOCE following placental growth factor (PlGF) treatment[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

398.41

Formula

C₂₁H₂₂N₂O₆

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 83.33 mg/mL (209.16 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5100 mL 12.5499 mL 25.0998 mL
5 mM 0.5020 mL 2.5100 mL 5.0200 mL
10 mM 0.2510 mL 1.2550 mL 2.5100 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 5 mg/mL (12.55 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 5 mg/mL (12.55 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 5 mg/mL (12.55 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.27%

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Product Name:
MRS1845
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HY-103310
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