1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. Calcium Channel
    CRAC Channel
  3. MRS1845


Cat. No.: HY-103310
Handling Instructions

MRS1845 is a selective store-operated calcium (SOC) channel inhibitor with an IC50 of 1.7 μM. MRS1845 is an ORAI1 inhibitor.

For research use only. We do not sell to patients.

MRS1845 Chemical Structure

MRS1845 Chemical Structure

CAS No. : 544478-19-5

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MRS1845 is a selective store-operated calcium (SOC) channel inhibitor with an IC50 of 1.7 μM[1]. MRS1845 is an ORAI1 inhibitor[2][3].

IC50 & Target

Ca2+ channel[1]

In Vitro

Treatment with MRS1845 (10 μM) virtually disrupts the effects of β-glycerophosphate on store-operated Ca2+ entry (SOCE)[2].
MRS1845 (10 μM) significantly decreases SOCE and virtually abolishes the increase of SOCE following placental growth factor (PlGF) treatment[3].

Molecular Weight









Room temperature in continental US; may vary elsewhere.


Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : ≥ 83.33 mg/mL (209.16 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5100 mL 12.5499 mL 25.0998 mL
5 mM 0.5020 mL 2.5100 mL 5.0200 mL
10 mM 0.2510 mL 1.2550 mL 2.5100 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.22 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.22 mM); Clear solution

*All of the co-solvents are provided by MCE.
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  • Molarity Calculator

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MRS1845MRS 1845MRS-1845Calcium ChannelCRAC ChannelCa2+ channelsCa channelsCalcium release-activated channelsCa2+ release-activated Ca2+ channelscalciumchannelSOCSOCEORAI1Inhibitorinhibitorinhibit

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