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ATP2C2 - ATPase secretory pathway Ca2+ transporting 2 Gene

Also Known as SPCA2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9914

About ATP2C2

Cytogenetic location: 16q24.1 Genomic coordinates (GRCh38): 16:84,368,538-84,464,187 (from NCBI)

This gene has 15 transcripts (splice variants), 312 orthologues and 21 paralogues. Biased expression in colon (RPKM 16.5), skin (RPKM 9.9) and 12 other tissues.

Summary

Enables P-type calcium transporter activity and P-type manganese transporter activity. Predicted to be involved in calcium ion transmembrane transport; cellular calcium ion homeostasis; and manganese ion transport. Predicted to act upstream of or within mammary gland epithelium development; positive regulation of calcium ion import; and protein localization to plasma membrane. Predicted to be located in trans-Golgi network membrane. Predicted to be active in Golgi membrane; endoplasmic reticulum; and plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

ATP2C2 Products (3)

mRNA	Protein	Name
NM_001286527.3	NP_001273456.2	calcium-transporting ATPase type 2C member 2 isoform 1
NM_001291454.2	NP_001278383.1	calcium-transporting ATPase type 2C member 2 isoform 3
NM_014861.4	NP_055676.3	calcium-transporting ATPase type 2C member 2 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables P-type calcium transporter activity	IDA IDA: Inferred from direct assay	15677451	GOA
enables P-type manganese transporter activity	IDA IDA: Inferred from direct assay	15831496	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20887894	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATP2C2 Protein Structure

Cation_ATPase_N

E1-E2_ATPase

Hydrolase

Cation_ATPase_C

0
200
400
600
800
946 a.a.

Protein Preferred Names	Protein Names
calcium-transporting ATPase type 2C member 2	ATPase 2C2

ATP2C2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ATP2C2	O75185	ORAI1	Homo sapiens	Q96D31	Anti Tag CoIP	20887894
Intra	ATP2C2	O75185	ORAI1	Homo sapiens	Q96D31	Anti Bait CoIP	20887894

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Dyslexia
Benign Chronic Pemphigus	Hailey-Hailey Disease Pemphigus, Benign Familial Familial Benign Pemphigus Benign Familial Pemphigus Familial Benign Chronic Pemphigus BCPM HHD Benign Chronic Familial Pemphigus Of Hailey-Hailey Pemphigus, Chronic, Benign
Speech And Communication Disorders	Language Disorder Communication Disorder Language Disorders Communication Disorders Speech Language Disorder Speech-Language Disorder Communication Impairment Speech And Language Disorder
Reading Disorder	Specific Reading Disorder Reading Dyslexia Developmental Reading Disorder
Triple-Receptor Negative Breast Cancer
Expressive Language Disorder	Developmental Expressive Language Disorder
Specific Language Impairment	Language Impairment, Specific
Developmental Coordination Disorder	Motor Skills Disorders
Mixed Receptive-Expressive Language Disorder
Learning Disability	Learning Disabilities Learning Disorders Academic Skill Disorder Learning Disorder
Speech Disorder	Speech Disorders
Stuttering	Stammering Familial Persistent Stuttering Stuttering, Familial Persistent 1
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity
Benign Epilepsy With Centrotemporal Spikes	Rolandic Epilepsy Benign Rolandic Epilepsy Epilepsy, Rolandic Bcects Benign Childhood Epilepsy With Centrotemporal Spike Sylvan Seizures Becrs Bects Bre Benign Epilepsy Of Childhood With Centrotemporal Spikes Benign Familial Epilepsy Of Childhood With Rolandic Spikes Centrotemporal Epilepsy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01199	ATP2C2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ATP2C2	RGD	RGD:620647
Macaca mulatta	ATP2C2	VGNC	VGNC:70149
Bos taurus	ATP2C2	VGNC	VGNC:26297
Canis familiaris	ATP2C2	VGNC	VGNC:38261
Mus musculus	ATP2C2	MGD	MGI:1916297
Felis catus	ATP2C2	VGNC	VGNC:60020
Others	ATP2C2	NCBI