ATP2C2 - ATPase secretory pathway Ca2+ transporting 2 Gene

Homo sapiens

Also known as SPCA2

Gene ID: 9914 | Gene type: protein coding

About ATP2C2

Cytogenetic location: 16q24.1 Genomic coordinates (GRCh38): 16:84,368,538-84,464,187 (from NCBI)

This gene has 15 transcripts (splice variants), 312 orthologues and 21 paralogues. Biased expression in colon (RPKM 16.5), skin (RPKM 9.9) and 12 other tissues.

Summary

Enables P-type calcium transporter activity and P-type manganese transporter activity. Predicted to be involved in calcium ion transmembrane transport; cellular calcium ion homeostasis; and manganese ion transport. Predicted to act upstream of or within mammary gland epithelium development; positive regulation of calcium ion import; and protein localization to plasma membrane. Predicted to be located in trans-Golgi network membrane. Predicted to be active in Golgi membrane; endoplasmic reticulum; and plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

ATP2C2 Products(3)

mRNA	Protein	Name
NM_001286527.3	NP_001273456.2	calcium-transporting ATPase type 2C member 2 isoform 1
NM_001291454.2	NP_001278383.1	calcium-transporting ATPase type 2C member 2 isoform 3
NM_014861.4	NP_055676.3	calcium-transporting ATPase type 2C member 2 isoform 2

ATP2C2 Protein Structure

Cation_ATPase_N

E1-E2_ATPase

Hydrolase

Cation_ATPase_C

0
200
400
600
800
946 a.a.

Protein Preferred Names

Protein Names

calcium-transporting ATPase type 2C member 2

ATPase 2C2

Related Diseases

Diseases

Alias

Dyslexia

Benign Chronic Pemphigus

Hailey-Hailey Disease	Pemphigus, Benign Familial
Familial Benign Pemphigus	Benign Familial Pemphigus
Familial Benign Chronic Pemphigus	BCPM
HHD	Benign Chronic Familial Pemphigus Of Hailey-Hailey
Pemphigus, Chronic, Benign

Speech And Communication Disorders

Language Disorder	Communication Disorder
Language Disorders	Communication Disorders
Speech Language Disorder	Speech-Language Disorder
Communication Impairment	Speech And Language Disorder

Reading Disorder

Specific Reading Disorder	Reading
Dyslexia	Developmental Reading Disorder

Triple-Receptor Negative Breast Cancer

Expressive Language Disorder

Developmental Expressive Language Disorder

Specific Language Impairment

Language Impairment, Specific

Developmental Coordination Disorder

Motor Skills Disorders

Mixed Receptive-Expressive Language Disorder

Learning Disability

Learning Disabilities	Learning Disorders
Academic Skill Disorder	Learning Disorder

Speech Disorder

Speech Disorders

Stuttering

Stammering	Familial Persistent Stuttering
Stuttering, Familial Persistent 1

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Benign Epilepsy With Centrotemporal Spikes

Rolandic Epilepsy	Benign Rolandic Epilepsy
Epilepsy, Rolandic	Bcects
Benign Childhood Epilepsy With Centrotemporal Spike	Sylvan Seizures
Becrs	Bects
Bre	Benign Epilepsy Of Childhood With Centrotemporal Spikes
Benign Familial Epilepsy Of Childhood With Rolandic Spikes	Centrotemporal Epilepsy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01199	ATP2C2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ATP2C2	RGD	RGD:620647
Macaca mulatta	ATP2C2	VGNC	VGNC:70149
Bos taurus	ATP2C2	VGNC	VGNC:26297
Canis familiaris	ATP2C2	VGNC	VGNC:38261
Mus musculus	ATP2C2	MGD	MGI:1916297
Felis catus	ATP2C2	VGNC	VGNC:60020

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