Cat. No.: HY-100001

SKF-96365 (hydrochloride)

28 Cited Publications

Customer Review

Based on 28 publication(s) in Google Scholar

SKF-96365 hydrochloride is a TRPC channel antagonist and store-operated calcium entry (SOCE) inhibitor. SKF-96365 hydrochloride reduces calcium ion influx by inhibiting the activity and expression of TRPC6, STIM1 and Orai1. SKF-96365 hydrochloride inhibits voltage-gated sodium current (cardiac I_Na/NaV1.5) and slows myocardial conduction. SKF-96365 hydrochloride inhibits phosphorylation/activation of CaMKIIγ and suppresses the downstream AKT signaling pathway. SKF-96365 hydrochloride induces G₂/M phase cell cycle arrest, apoptosis and cytoprotective autophagy in colorectal cancer cells. SKF-96365 hydrochloride alleviates allergic rhinitis symptoms by reducing inflammatory cytokine levels. SKF-96365 hydrochloride reduces intracellular calcium overload, inhibits Homer1 expression, prevents nuclear damage and suppresses apoptosis. SKF-96365 hydrochloride inhibits the growth of colorectal cancer xenografts in nude mice. SKF-96365 hydrochloride is applicable to research related to allergic rhinitis, colorectal cancer, Parkinson's disease, persistent spontaneous nociception and hyperalgesia.

For research use only. We do not sell to patients.

Purity: 99.93%
CAS No.: 130495-35-1
Formula: C₂₂H₂₇ClN₂O₃
Molecular Weight:402.91

Storage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

SKF-96365 (hydrochloride) Chemical Structure

CAS No.: 130495-35-1

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (28)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All TRP Channel Isoforms :

All CaMK Isoforms :

All Akt Isoforms :

All Calcium Channel Isoforms :

In Vitro

SKF-96365 (0-10 μM; applied until steady-state inhibition is reached) hydrochloride inhibits hNaV1.5 currents stably expressed in HEK 293 cells, with an IC₅₀ of 0.94 μM^[2].
SKF-96365 (0-20 μM) hydrochloride dose-dependently inhibits store-operated calcium entry in human colorectal cancer cell lines HCT116 and HT29^[3].
SKF-96365 (0-40 μM, 48-72 h) hydrochloride inhibits the growth of human colorectal cancer cells HCT116 (IC₅₀ = 10.88 μM) and HT29 (IC₅₀ = 14.56 μM), and exhibits significantly lower toxicity against normal colonic epithelial cells NCM460^[3].
SKF-96365 (0-20 μM, 48 h) hydrochloride induces G₂/M cell cycle arrest in human colorectal cancer cells HCT116 and HT29 by regulating key G₂/M transition proteins, including upregulating p21waf/Cip1 and downregulating p-Cdc25c, Cdc25c, and Cyclin B^[3].
SKF-96365 (10 μM, 0-24 h) hydrochloride induces apoptosis in human colorectal cancer cell lines HCT116 and HT29 via the endogenous mitochondrial pathway, a process characterized by early (12 h) mitochondrial membrane depolarization, Bax translocation and cytochrome c release, followed by caspase activation and marked apoptosis (24 h)^[3].
SKF-96365 (0-20 μM, 12 h) hydrochloride induces cytoprotective autophagy in human colorectal cancer cells HCT116 and HT29. This effect appears as early as 12 h (prior to apoptosis) and antagonizes apoptosis by sequestering mitochondria into autophagosomes to reduce cytosolic cytochrome c levels^[3].
SKF-96365 (0-20 μM, 24 h) hydrochloride inhibits the AKT/mTOR signaling pathway and the calcium/Ca²⁺/CaMKIIγ/AKT signaling pathway in human colorectal cancer cell lines HCT116 and HT29^[3].
SKF-96365 (1-50 μM, 24 h) hydrochloride significantly increases the survival rate of PC12 cells treated with MPP⁺, reduces LDH release, alleviates nuclear damage, membrane damage, and late apoptotic cell death, mitigates intracellular calcium overload, and decreases the mRNA and protein expression levels of Homer1^[4].
SKF-96365 (1-10 µM) hydrochloride inhibits melittin-induced inward currents in acutely isolated small and medium-sized dorsal root ganglion cells of rats in a dose-dependent manner^[5].
SKF-96365 (10 µM) hydrochloride inhibits melittin-induced intracellular Ca²⁺ elevation, and the proportion of cells exhibiting this inhibitory effect reaches 46.5% in acutely isolated rat dorsal root ganglion cells sensitive to melittin^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[4]

Cell Line:

PC12 (adrenal gland pheochromocytoma) cells
Concentration:

1 μM, 10 μM, 50 μM
Incubation Time:

30 min pretreatment before MPP+ insult; 24 h post-MPP+ measurement
Result:

Significantly inhibited the MPP⁺-induced decrease in cell viability at 10 μM and 50 μM, with viability levels significantly higher than the MPP+-treated vehicle group.
Did not show a significant effect on cell viability compared to the vehicle group at 1 μM.
Did not affect cell viability in untreated normal PC12 cells at all tested concentrations.

Apoptosis Analysis^[4]

Cell Line:

PC12 cells
Concentration:

50 μM
Incubation Time:

30 min pretreatment before MPP+ insult; 24 h post-MPP+ flow cytometry
Result:

Increased the percentage of normal (AV^-/PI^-) cells compared to the MPP+-treated vehicle group.
Decreased the percentage of late apoptotic (AV⁺/PI⁺) cells compared to the MPP+-treated vehicle group.
Showed no significant effect on necrotic (AV^-/PI⁺) cells.

Real Time qPCR^[4]

Cell Line:

PC12 cells
Concentration:

50 μM
Incubation Time:

30 min pretreatment before MPP+ insult; measured at 3 h, 6 h, 12 h post-MPP+
Result:

Significantly decreased Homer1 mRNA expression in a time-dependent manner, with significant reductions observed at 3 h, 6 h, and 12 h post-MPP+ insult compared to the MPP+-treated vehicle group.
MPP+ alone did not alter Homer1 mRNA expression compared to untreated control cells.

Western Blot Analysis^[4]

Cell Line:

PC12 cells
Concentration:

50 μM
Incubation Time:

30 min pretreatment before MPP+ insult; 24 h post-MPP+ measurement
Result:

Significantly decreased Homer1 protein expression in a time-dependent manner, with significant reductions observed at 3 h, 6 h, and 12 h post-MPP+ insult compared to the MPP+-treated vehicle group.
MPP+ alone did not alter Homer1 protein expression compared to untreated control cells.

In Vivo

SKF-96365 (200-400 μg; intranasal administration; once daily; for 8 consecutive days) hydrochloride dose-dependently alleviates allergic rhinitis symptoms and suppresses inflammatory responses in BALB/c mice^[1].
SKF-96365 (20 mg/kg; i.p.; once daily for 14 consecutive days) hydrochloride inhibits the growth of colorectal cancer xenografts in athymic BALB/c nude mice by inducing cell cycle arrest, apoptosis and protective autophagy via suppressing the CaMKIIγ/AKT-mediated pathway^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c (female; allergic rhinitis model via intraperitoneal sensitization and intranasal challenge)^[1]
Dosage:

200 μg; 400 μg
Administration:

i.n.; once daily; 8 days (1 hour before ovalbumin challenge)
Result:

Significantly reduced frequencies of sneezing and nasal rubbing compared to untreated allergic rhinitis mice, with the 400 μg dose being more effective than the 200 μg dose.
Significantly decreased serum levels of OVA-specific IgE, histamine, and LTC4 compared to untreated allergic rhinitis mice, with greater reductions observed in the 400 μg group.
Significantly decreased nasal lavage fluid levels of OVA-specific IgE, IL-4, IL-5, IL-6, IL-13, and IL-33 compared to untreated allergic rhinitis mice, with greater reductions observed in the 400 μg group.
Significantly decreased counts of total inflammatory cells, eosinophils, macrophages, neutrophils, and lymphocytes in nasal lavage fluid compared to untreated allergic rhinitis mice, with greater reductions observed in the 400 μg group.
Reduced eosinophil counts in nasal mucosa compared to untreated allergic rhinitis mice, with the 400 μg dose producing more pronounced effects than the 200 μg dose.
Downregulated TRPC6 immunolabeling in nasal mucosa compared to untreated allergic rhinitis mice, with the 400 μg dose producing more pronounced effects than the 200 μg dose.
Decreased nasal mucosa mRNA levels of TRPC6, STIM1, and Orai1 compared to untreated allergic rhinitis mice, with the 400 μg dose producing more pronounced effects than the 200 μg dose.

Chemical Information

CAS No. 130495-35-1
Appearance Solid
Molecular Weight 402.91
Formula C₂₂H₂₇ClN₂O₃
Color White to light yellow
SMILES

COC1=CC=C(CCCOC(C2=CC=C(OC)C=C2)CN3C=CN=C3)C=C1.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (28)

All IFRT-PCRCell Migration/Invasion AssayWB

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Journal Impact Factor

Nat Immunol

Lipid asymmetry disruption by XKR8 orchestrates neutrophil extracellular trap formation and inhibits fungal infection. [Abstract]

2026 May;27(5):949-960. PMID: 41781710
Bioact Mater

Improved activity of MC3T3-E1 cells by the exciting piezoelectric BaTiO3/TC4 using low-intensity pulsed ultrasound. [Abstract]

2021 Apr 21;6(11):4073-4082. PMID: 33997494

SKF-96365 (hydrochloride) purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2021 Apr 21;6(11):4073-4082. [Abstract]

Intracellular calcium fluorescence staining of MC3T3-E1 cells on day 1 in a blank and samples inhibited by verapamil (10 μmol/L, 24 h) or SKF-96365 (10 μmol/L, 24 h).

SKF-96365 (hydrochloride) purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2021 Apr 21;6(11):4073-4082. [Abstract]

SKF-96365 (100 μM; 2 h) significantly inhibits the mRNA levels of the HSV-1 UL30 gene in Trpv2^fl/fl BMDCs but not in Lyz2-Cre;Trpv2^fl/fl BMDCs.
Autophagy

Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4. [Abstract]

2021 Nov;17(11):3592-3606. PMID: 33629929
Theranostics

TRPV2-spike protein interaction mediates the entry of SARS-CoV-2 into macrophages in febrile conditions. [Abstract]

2021 May 25;11(15):7379-7390. PMID: 34158856
Theranostics

FGF19/SOCE/NFATc2 signaling circuit facilitates the self-renewal of liver cancer stem cells. [Abstract]

2021 Mar 5;11(10):5045-5060. PMID: 33754043

SKF-96365 (hydrochloride) purchased from MedChemExpress. Usage Cited in: Theranostics. 2021 Mar 5;11(10):5045-5060. [Abstract]

WB were applied to measure levels of Nanog, Oct-4, Sox2 and ALB in FGF19 (100 ng/ml) treated NCSCs, in the presence of SKF-96365 (5 µM) or not.
Theranostics

STIM1 is a metabolic checkpoint regulating the invasion and metastasis of hepatocellular carcinoma. [Abstract]

2020 May 16;10(14):6483-6499. PMID: 32483465

SKF-96365 (hydrochloride) purchased from MedChemExpress. Usage Cited in: Theranostics. 2020 May 16;10(14):6483-6499. [Abstract]

Transwell assays were performed to detect the effects of different concentrations SKF-96365 on the invasion ability of Snail1 OE-SMMC7721 and HepG2 cells. The results show that SKF-96365 (2-5 μM) enhances the invasive ability of hepatocellular carcinoma cells with Snail1 overexpression.
Adv Sci (Weinh)

Hyperviscous Diabetic Bone Marrow Niche Impairs BMSCs Osteogenesis via TRPV2-Mediated Cytoskeletal-Nuclear Mechanotransduction. [Abstract]

2025 Dec 22:e09056. PMID: 41431162
Adv Sci (Weinh)

The Transient Receptor Potential Vanilloid 2 (TRPV2) Channel Facilitates Virus Infection Through the Ca2+ -LRMDA Axis in Myeloid Cells. [Abstract]

2022 Oct 19;e2202857. PMID: 36261399
Cell Death Differ

OR2T6 modulates autophagy through the PPP3CA-mediated pathways to suppress gastric cancer. [Abstract]

2025 Nov 10. PMID: 41214150
Stem Cell Res Ther

Nano-zinc oxide (nZnO) targets the AMPK-ULK1 pathway to promote bone regeneration. [Abstract]

2025 Apr 24;16(1):206. PMID: 40275329

SKF-96365 (hydrochloride) purchased from MedChemExpress. Usage Cited in: Stem Cell Res Ther. 2025 Apr 24;16(1):206. [Abstract]

Western blot analysis of CaMKK2, AMPK activation and RUNX2 in MSCs after osteogenic differentiation for 72 h treated with TRP channel blocker SKF-96,365 hydrochloride (SKF, 2 µM) under control and nZnO (5 µg/mL) conditions.
Cell Rep

Viral infection and spread are inhibited by the polyubiquitination and downregulation of TRPV2 channel by the interferon-stimulated gene TRIM21. [Abstract]

2024 Apr 23;43(4):114095. PMID: 38613787
Br J Pharmacol

Small intestinal glucose and sodium absorption through calcium-induced calcium release and store-operated Ca2+ entry mechanisms. [Abstract]

2021 Jan;178(2):346-362. PMID: 33080043
J Agric Food Chem

miR-2765 Modulates the Seasonal Polyphenism in Cacopsylla chinensis by Targeting a Novel Cold Rreceptor CcTRPC3. [Abstract]

2024 Jan 10;72(1):140-152. PMID: 38118125
Cells

Impact of Short-Term (+)-JQ1 Exposure on Mouse Aorta: Unanticipated Inhibition of Smooth Muscle Contractility. [Abstract]

2023 May 24;12(11):1461. PMID: 37296583
Eur J Pharmacol

Novel mechanisms of metformin-induced vasorelaxation of mesenteric arterioles via endothelium-dependent hyperpolarization to treat murine colitis. [Abstract]

2025 Sep 15:1003:177900. PMID: 40617384
Acta Physiol

The CaSR/TRPV4 coupling mediates pro-inflammatory macrophage function. [Abstract]

2023 Apr;237(4):e13926. PMID: 36606511
Front Pharmacol

Role of Serosal TRPV4-Constituted SOCE Mechanism in Secretagogues-Stimulated Intestinal Epithelial Anion Secretion. [Abstract]

2021 Jul 14:12:684538. PMID: 34335254
Chem Biol Interact

Platycodin D reverses tumor necrosis factor-α-induced endothelial dysfunction by increasing nitric oxide through G protein-coupled estrogen receptor-mediated eNOS activity. [Abstract]

2025 Sep 5:418:111577. PMID: 40447174
J Neuroendocrinol

The caudal neurosecretory system: A novel thermosensitive tissue and its signal pathway in olive flounder (Paralichthys olivaceus). [Abstract]

2020 Jun;32(6):e12876. PMID: 32542811
Mol Cell Biochem

Inhibition of STIM1 alleviates high glucose-induced proliferation and fibrosis by inducing autophagy in mesangial cells. [Abstract]

2024 Sep;479(9):2365-2379. PMID: 37736800
Acta Biochim Biophys Sin (Shanghai)

Combined bone marrow stromal cells and oxiracetam treatments ameliorates acute cerebral ischemia/reperfusion injury through TRPC6. [Abstract]

2019 Aug 5;51(8):767-777. PMID: 31236585
Front Physiol

Cyclopiazonic Acid-Induced Ca2+ Store Depletion Initiates Endothelium-Dependent Hyperpolarization-Mediated Vasorelaxation of Mesenteric Arteries in Healthy and Colitis Mice. [Abstract]

2021 Mar 9:12:639857. PMID: 33767636
FASEB J

Leucine-rich repeat kinase 2 regulates mouse dendritic cell migration by ORAI2. [Abstract]

2019 Sep;33(9):9775-9784. PMID: 31166814
J Pharm Pharmacol

Homoplantaginin attenuates high glucose-induced vascular endothelial dysfunction via inhibiting store-operated calcium entry channel and endoplasmic reticulum stress. [Abstract]

2023 Dec 8;75(12):1530-1543. PMID: 37774413
Biochem Biophys Res Commun

Glucose transports in the ileum: mechanism, regulation and physiological role of ileal glucose absorption. [Abstract]

2025 Sep 19:785:152676. PMID: 41005286
Physiol Rep

Monosodium glutamate-mediated Ca2+-dependent intestinal epithelial ion transports in health and IBS-D in male mice. [Abstract]

2026 Jun;14(11):e70975. PMID: 42281391
Res Sq

2024 Jun 11.
Heliyon

N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine induces endothelium-dependent hyperpolarization-mediated vasorelaxation via store-operated calcium entry mechanism in healthy and intestinal inflammatory mice. [Abstract]

2024 Jul 6;10(14):e33994. PMID: 39108891

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (248.19 mM; Need ultrasonic; DMSO can inactivate SKF-96365 (hydrochloride)'s activity)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.4819 mL

12.4097 mL

24.8194 mL

5 mM

0.4964 mL

2.4819 mL

4.9639 mL

10 mM

0.2482 mL

1.2410 mL

2.4819 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: Saline

Solubility: 100 mg/mL (248.19 mM); Clear solution; Need ultrasonic

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (286 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ba G, et al. Therapeutic effects of SKF-96365 on murine allergic rhinitis induced by OVA. Int J Immunopathol Pharmacol. 2021;35:20587384211015054. [Content Brief]

[2]. Chen KH, et al. SKF-96365 strongly inhibits voltage-gated sodium current in rat ventricular myocytes. Pflugers Arch. 2015;467(6):1227-1236. [Content Brief]

[3]. Jing Z, et al. SKF-96365 activates cytoprotective autophagy to delay apoptosis in colorectal cancer cells through inhibition of the calcium/CaMKIIγ/AKT-mediated pathway. Cancer Lett. 2016;372(2):226-238. [Content Brief]

[4]. Chen T, et al. Protective effects of SKF-96365, a non-specific inhibitor of SOCE, against MPP+-induced cytotoxicity in PC12 cells: potential role of Homer1. PLoS One. 2013;8(1):e55601. [Content Brief]

[5]. Ding J, et al. Effects of SKF-96365, a TRPC inhibitor, on melittin-induced inward current and intracellular Ca2+ rise in primary sensory cells. Neurosci Bull. 2011;27(3):135-142. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	2.4819 mL	12.4097 mL	24.8194 mL	62.0486 mL
	5 mM	0.4964 mL	2.4819 mL	4.9639 mL	12.4097 mL
	10 mM	0.2482 mL	1.2410 mL	2.4819 mL	6.2049 mL
	15 mM	0.1655 mL	0.8273 mL	1.6546 mL	4.1366 mL
	20 mM	0.1241 mL	0.6205 mL	1.2410 mL	3.1024 mL
	25 mM	0.0993 mL	0.4964 mL	0.9928 mL	2.4819 mL
	30 mM	0.0827 mL	0.4137 mL	0.8273 mL	2.0683 mL
	40 mM	0.0620 mL	0.3102 mL	0.6205 mL	1.5512 mL
	50 mM	0.0496 mL	0.2482 mL	0.4964 mL	1.2410 mL
	60 mM	0.0414 mL	0.2068 mL	0.4137 mL	1.0341 mL
	80 mM	0.0310 mL	0.1551 mL	0.3102 mL	0.7756 mL
	100 mM	0.0248 mL	0.1241 mL	0.2482 mL	0.6205 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

SKF-96365 (hydrochloride)

28 Cited Publications

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SKF-96365 (hydrochloride)

Bioactive Compound Library Max

Bioactive Compound Library

Apoptosis Compound Library

Immunology/Inflammation Compound Library

Kinase Inhibitor Library

Membrane Transporter/Ion Channel Compound Library

Neuronal Signaling Compound Library

PI3K/Akt/mTOR Compound Library

Stem Cell Signaling Compound Library

Anti-Cancer Compound Library

Autophagy Compound Library

Anti-Aging Compound Library

Differentiation Inducing Compound Library

Oxygen Sensing Compound Library

Glycolysis Compound Library

Cytoskeleton Compound Library

Glutamine Metabolism Compound Library

Neuroprotective Compound Library

Anti-Breast Cancer Compound Library

Anti-Lung Cancer Compound Library

Anti-Pancreatic Cancer Compound Library

Anti-Blood Cancer Compound Library

Anti-Cancer Metabolism Compound Library

Anti-Parkinson's Disease Compound Library

Neurodegenerative Disease-related Compound Library

Anti-Obesity Compound Library

Angiogenesis-Related Compound Library

Glucose Metabolism Compound Library

Mechanoreceptors Compound Library

Anti-Liver Cancer Compound Library

Anti-Colorectal Cancer Compound Library

Calcium Channel Blocker Library

Anti-Prostate Cancer Compound Library

Anti-Pulmonary Fibrosis Compound Library

Cancer Stem Cells Compound Library

Pain-Related Compound Library

Antihypertensive Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Cell Death Library

Serine/Threonine Kinase Inhibitor Library

Ion Channel Compound Library

Anti-Hematopathy Compound Library

Anti-Ovarian Cancer Compound Library

Multi-Target Compound Library

MCE Bioactive Compound Library

Anti-Gastric Cancer Compound Library

Anti-Fibrosis Compound Library

Protein Kinase Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

Cell Proliferation Compound Library

High-Throughput Bioactive Compound Library

Lactylation Compound Library

Publications Citing Use of MedChemExpress (MCE) SKF-96365 (hydrochloride)

All TRP Channel Isoforms

All CaMK Isoforms

All Akt Isoforms

All Calcium Channel Isoforms

Biological Activity

Chemical Information

Publications (28)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

SKF-96365 (hydrochloride) Related Classifications

HY-100001 Related Classifications