1. Membrane Transporter/Ion Channel
  2. TRP Channel

SB-366791 (Synonyms: SB366791; SB 366791)

Cat. No.: HY-12245 Purity: 98.01%
Data Sheet SDS Handling Instructions

SB-366791 is a potent , competitive and selective vanilloid receptor (VR1/TRPV1) antagonist with IC50 of 5.7±1.2 nM

For research use only. We do not sell to patients.
SB-366791 Chemical Structure

SB-366791 Chemical Structure

CAS No. : 472981-92-3

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10 mM * 1 mL in DMSO $55 In-stock
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10 mg $70 In-stock
25 mg $150 In-stock
50 mg $240 In-stock
100 mg $400 In-stock
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Description

SB-366791 is a potent , competitive and selective vanilloid receptor (VR1/TRPV1) antagonist with IC50 of 5.7±1.2 nM target: VR1/TRPV1 IC 50: 5.7±1.2 nM [1] SB-366791 produced a concentration-dependent inhibition of the response to capsaicin with an apparent pKb of 7.74±0.08. Schild analysis indicated a competitive mechanism of action with a pA2 of 7.71.[1] SB-366791 showed a concentration-dependent potentiation of pH 5-induced 45Ca2+uptake in CHO cells expressing rat TRPV1 but not in untransfected cells[2]

References
M.Wt

287.74

Formula

C₁₆H₁₄ClNO₂

CAS No.

472981-92-3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
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Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 39 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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SB-366791
Cat. No.:
HY-12245
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