472981-92-3
472981-92-3
Chemical Structure
SB-366791
- CAS. Nr.: 472981-92-3
- Formula:C16H14ClNO2
- Molecular Weight:287.74
IUPAC Name: (E)-3-(4-chlorophenyl)-N-(3-methoxyphenyl)acrylamide
InChIKey: RYAMDQKWNKKFHD-JXMROGBWSA-N
SMILES: O=C(NC1=CC=CC(OC)=C1)/C=C/C2=CC=C(Cl)C=C2
Biological Activity: SB-366791 is a potent and selective vanilloid receptor (VR1/TRPV1) antagonist (IC50=5.7 nM). SB-366791 can be used for the research of inflammation[1][2].
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SB-366791 | 99.29% | SB-366791 is a potent and selective vanilloid receptor (VR1/TRPV1) antagonist (IC50=5.7 nM). SB-366791 can be used for the research of inflammation. | ||||||||||||||||||||
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References
- [1]. Lappin SC, et al. TRPV1 antagonist, SB-366791, inhibits glutamatergic synaptic transmission in rat spinal dorsal horn following peripheral inflammation. Eur J Pharmacol. 2006;540(1-3):73-81. [Content Brief]
- [2]. Gunthorpe MJ, et al. Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist [published correction appears in Neuropharmacology. 2004 May;46(6):905]. Neuropharmacology. 2004;46(1):133-149. [Content Brief]
