(E)-N-(3-Methoxyphenyl)cinnamamide 

(E)-N-(3-Methoxyphenyl) cinnamamide (Compound 5h) is a weakly selective inhibitor of MMP-2 and MMP-9, with weak inhibitory activity against hMMP-2 and hMMP-9, showing IC₅₀ values of 1674.81 nM and 1658.63 nM, respectively, and low selectivity for MMP-1. (E)-N-(3-Methoxyphenyl) cinnamamide is applicable for cancer research^[1].

(E)-N-(3-Methoxyphenyl) cinnamamide (compound 5h) (0.1-10000 nM; 30 min) inhibits recombinant hMMP-2 and hMMP-9 with IC₅₀ values of 1674.81 nM and 1658.63 nM, respectively, and shows 3-fold higher selectivity for these MMPs than for recombinant hMMP-1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

253.30

C₁₆H₁₅NO₂

127033-74-3

Solid

N(C(/C=C/C1=CC=CC=C1)=O)C2=CC(OC)=CC=C2

Room temperature in continental US; may vary elsewhere.

Store at room temperature 3 years

• [1]. Shi ZH, et al. Synthesis and structure-activity relationship analysis of caffeic acid amides as selective matrix metalloproteinase inhibitors. Bioorg Med Chem Lett. 2013;23(5):1206-1211.  [Content Brief]