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Cat. No.: HY-W1057938

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(E)-N-(4-Methoxyphenyl)cinnamamide

(E)-N-(4-Methoxyphenyl)cinnamamide is a selective matrix metalloproteinase inhibitor with inhibitory activity against MMP-2 (IC₅₀ = 5.37 nM), MMP-9 (IC₅₀ = 6.21 nM), and low activity against MMP-1 (IC₅₀ = 5301.68 nM). (E)-N-(4-Methoxyphenyl)cinnamamide can be used for the research of tumor.

For research use only. We do not sell to patients.

CAS No.: 76228-15-4
Formula: C₁₆H₁₅NO₂
Molecular Weight:253.30

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

(E)-N-(4-Methoxyphenyl)cinnamamide Chemical Structure

CAS No.: 76228-15-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

IC₅₀ & Target

^[1]

MMP-2

5.37 nM (IC₅₀)

MMP-9

6.21 nM (IC₅₀)

All MMP Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MCF7	IC₅₀	2.34 μM Compound: 2g	Antiproliferative activity against Homo sapiens (human) MCF-7 cells overexpressing EGFR assessed as inhibition of cell survival after 48 hr by MTT assay Antiproliferative activity against Homo sapiens (human) MCF-7 cells overexpressing EGFR assessed as inhibition of cell survival after 48 hr by MTT assay	10.1007/s00044-012-0093-z
Sf9	IC₅₀	9.05 μM Compound: 2g	Inhibition of autophosphorylation of His6-tagged EGFR cytoplasmic domain (unknown origin) expressed in Sf9 cells by DELFIA time resolved fluorometry Inhibition of autophosphorylation of His6-tagged EGFR cytoplasmic domain (unknown origin) expressed in Sf9 cells by DELFIA time resolved fluorometry	10.1007/s00044-012-0093-z

In Vitro

(E)-N-(4-Methoxyphenyl)cinnamamide (compound 7i) (0.1-10000 nM; 30 min) potently inhibits human recombinant MMP-2 (IC₅₀ = 5.37 nM) and MMP-9 (IC₅₀ = 6.21 nM) with high selectivity over human recombinant MMP-1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 76228-15-4
Molecular Weight 253.30
Formula C₁₆H₁₅NO₂
SMILES

N(C(/C=C/C1=CC=CC=C1)=O)C2=CC=C(OC)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Shi ZH, et al. Synthesis and structure-activity relationship analysis of caffeic acid amides as selective matrix metalloproteinase inhibitors. Bioorganic & medicinal chemistry letters. 2013 Mar 01;23(5):1206-11. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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