BChE-IN-53
BChE-IN-53 is a butyrylcholinesterase (BChE) inhibitor with an IC50 value of 119.0 μM and is inactive against α-glucosidase. BChE-IN-53 can be used for the research of alzheimer's disease, type 2 diabetes mellitus.
For research use only. We do not sell to patients.
- CAS No.: 25870-73-9
- Formula: C16H15NO2
- Molecular Weight:253.30
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
BChE 119 μM (IC50) |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CCRF-CEM | IC50 |
14 μM
Compound: 8b
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Antiproliferative activity against human CEM cells after 48 hrs by Coulter counting analysis
Antiproliferative activity against human CEM cells after 48 hrs by Coulter counting analysis
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[PMID: 19250822] |
| FM3A | IC50 |
35 μM
Compound: 8b
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Antiproliferative activity against mouse FM3A cells after 48 hrs by Coulter counting analysis
Antiproliferative activity against mouse FM3A cells after 48 hrs by Coulter counting analysis
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[PMID: 19250822] |
| HCT-116 | IC50 |
19.75 μM
Compound: 5
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Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay
|
10.1039/C4MD00371C |
| HeLa | IC50 |
8.7 μM
Compound: 8b
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Antiproliferative activity against human HeLa cells after 48 hrs by Coulter counting analysis
Antiproliferative activity against human HeLa cells after 48 hrs by Coulter counting analysis
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[PMID: 19250822] |
| HL-60 | IC50 |
10.5 μM
Compound: 5
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Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
|
10.1039/C4MD00371C |
| L1210 | IC50 |
18 μM
Compound: 8b
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Antiproliferative activity against mouse L1210 cells after 48 hrs by Coulter counting analysis
Antiproliferative activity against mouse L1210 cells after 48 hrs by Coulter counting analysis
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[PMID: 19250822] |
| MOLT-4 | IC50 |
8.6 μM
Compound: 8b
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Antiproliferative activity against human MOLT4 cells after 48 hrs by Coulter counting analysis
Antiproliferative activity against human MOLT4 cells after 48 hrs by Coulter counting analysis
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[PMID: 19250822] |
| OVCAR-8 | IC50 |
19.75 μM
Compound: 5
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Cytotoxicity against human OVCAR8 cells after 72 hrs by MTT assay
Cytotoxicity against human OVCAR8 cells after 72 hrs by MTT assay
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10.1039/C4MD00371C |
| PBMC | IC50 |
19.75 μM
Compound: 5
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Cytotoxicity against human PBMC cells after 72 hrs by MTT assay
Cytotoxicity against human PBMC cells after 72 hrs by MTT assay
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10.1039/C4MD00371C |
| SF-295 | IC50 |
19.75 μM
Compound: 5
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Cytotoxicity against human SF295 cells after 72 hrs by MTT assay
Cytotoxicity against human SF295 cells after 72 hrs by MTT assay
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10.1039/C4MD00371C |
In Vitro
BChE-IN-53 (5-500 μM; 15 min enzyme incubation, 10 min substrate reaction) inhibits purified butyrylcholinesterase enzyme with an IC50 of 119.0 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 25870-73-9
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Molecular Weight 253.30
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Formula C16H15NO2
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SMILES
O=C(C=CC1=CC=C(OC)C=C1)C2=CC=C(N)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BChE-IN-53 Related Classifications
HY-W1058380 Related Classifications
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