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製品番号: HY-W1058380

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BChE-IN-53

BChE-IN-53 is a butyrylcholinesterase (BChE) inhibitor with an IC₅₀ value of 119.0 μM and is inactive against α-glucosidase. BChE-IN-53 can be used for the research of alzheimer's disease, type 2 diabetes mellitus.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 25870-73-9
分子式: C₁₆H₁₅NO₂
分子量:253.30

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

BChE-IN-53 構造式

CAS 番号: 25870-73-9

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target

^[1]

BChE

119 μM (IC₅₀)

Cholinesterase (ChE) アイソフォーム固有の製品をすべて表示 :

AChE
BChE

Cellular Effect

Cell Line	Type	Value	Description	References
CCRF-CEM	IC₅₀	14 μM Compound: 8b	Antiproliferative activity against human CEM cells after 48 hrs by Coulter counting analysis Antiproliferative activity against human CEM cells after 48 hrs by Coulter counting analysis	[PMID: 19250822]
FM3A	IC₅₀	35 μM Compound: 8b	Antiproliferative activity against mouse FM3A cells after 48 hrs by Coulter counting analysis Antiproliferative activity against mouse FM3A cells after 48 hrs by Coulter counting analysis	[PMID: 19250822]
HCT-116	IC₅₀	19.75 μM Compound: 5	Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay	10.1039/C4MD00371C
HeLa	IC₅₀	8.7 μM Compound: 8b	Antiproliferative activity against human HeLa cells after 48 hrs by Coulter counting analysis Antiproliferative activity against human HeLa cells after 48 hrs by Coulter counting analysis	[PMID: 19250822]
HL-60	IC₅₀	10.5 μM Compound: 5	Cytotoxicity against human HL60 cells after 72 hrs by MTT assay Cytotoxicity against human HL60 cells after 72 hrs by MTT assay	10.1039/C4MD00371C
L1210	IC₅₀	18 μM Compound: 8b	Antiproliferative activity against mouse L1210 cells after 48 hrs by Coulter counting analysis Antiproliferative activity against mouse L1210 cells after 48 hrs by Coulter counting analysis	[PMID: 19250822]
MOLT-4	IC₅₀	8.6 μM Compound: 8b	Antiproliferative activity against human MOLT4 cells after 48 hrs by Coulter counting analysis Antiproliferative activity against human MOLT4 cells after 48 hrs by Coulter counting analysis	[PMID: 19250822]
OVCAR-8	IC₅₀	19.75 μM Compound: 5	Cytotoxicity against human OVCAR8 cells after 72 hrs by MTT assay Cytotoxicity against human OVCAR8 cells after 72 hrs by MTT assay	10.1039/C4MD00371C
PBMC	IC₅₀	19.75 μM Compound: 5	Cytotoxicity against human PBMC cells after 72 hrs by MTT assay Cytotoxicity against human PBMC cells after 72 hrs by MTT assay	10.1039/C4MD00371C
SF-295	IC₅₀	19.75 μM Compound: 5	Cytotoxicity against human SF295 cells after 72 hrs by MTT assay Cytotoxicity against human SF295 cells after 72 hrs by MTT assay	10.1039/C4MD00371C

体外実験

BChE-IN-53 (5-500 μM; 15 min enzyme incubation, 10 min substrate reaction) inhibits purified butyrylcholinesterase enzyme with an IC₅₀ of 119.0 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

化学情報

CAS 番号 25870-73-9
分子量 253.30
分子式 C₁₆H₁₅NO₂
SMILES

O=C(C=CC1=CC=C(OC)C=C1)C2=CC=C(N)C=C2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (265 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Jabeen F, et al. Dual inhibition of the α-glucosidase and butyrylcholinesterase studied by molecular field topology analysis. European journal of medicinal chemistry. 2014 Jun 10;80:228-42. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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