AChE/BChE-IN-31
AChE/BChE-IN-31 (Compound 3c) is a cholinesterase inhibitor. AChE/BChE-IN-31 exhibits certain inhibitory activity against hAChE and eqBChE. AChE/BChE-IN-31 also possesses antioxidant properties with an IC50 value of 105.04 μM against DPPH. AChE/BChE-IN-31 can be used in the research of diseases such as Alzheimer’s disease.
For research use only. We do not sell to patients.
- CAS No.: 6338-81-4
- Formula: C16H14O3
- Molecular Weight:254.29
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| CCRF-CEM | IC50 |
5.9 μM
Compound: 14
|
Concentration required to inhibit 50% growth of Human CEM T-lymphocytes cells
Concentration required to inhibit 50% growth of Human CEM T-lymphocytes cells
|
[PMID: 9544201] |
| K562 | IC50 |
9.9 μM
Compound: 2uu
|
Antiproliferative activity against human K562 cells after 5 days by MTT assay
Antiproliferative activity against human K562 cells after 5 days by MTT assay
|
[PMID: 19837593] |
| L1210 | IC50 |
32.2 μM
Compound: 14
|
Concentration required to inhibit 50% growth of L1210 leukemia cells
Concentration required to inhibit 50% growth of L1210 leukemia cells
|
[PMID: 9544201] |
| P388 | IC50 |
8.7 μM
Compound: 14
|
Inhibition of proliferation of murine P388 cells
Inhibition of proliferation of murine P388 cells
|
[PMID: 9544201] |
Chemical Information
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CAS No. 6338-81-4
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Molecular Weight 254.29
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Formula C16H14O3
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SMILES
O=C(C=CC1=CC=C(OC)C=C1)C2=CC=C(O)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)