1. Membrane Transporter/Ion Channel
    Neuronal Signaling
    Autophagy
    Apoptosis
  2. TRP Channel
    Autophagy
    Apoptosis
  3. Capsaicin

Capsaicin (Synonyms: (E)-Capsaicin)

Cat. No.: HY-10448 Purity: 99.79%
Handling Instructions

Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin has pain relief, antioxidant, anti-inflammatory, neuroprotection and anti-cancer effects.

For research use only. We do not sell to patients.

Capsaicin Chemical Structure

Capsaicin Chemical Structure

CAS No. : 404-86-4

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Customer Review

Based on 22 publication(s) in Google Scholar

Other Forms of Capsaicin:

Top Publications Citing Use of Products

    Capsaicin purchased from MCE. Usage Cited in: Clin Exp Pharmacol Physiol. 2017 Jul;44(7):803-814.

    Western blot analysis showing that the CAP (0.5 mg/kg) injection inhibits the increase of p65 expression and phosphorylation at 24 h after I/R injury.

    Capsaicin purchased from MCE. Usage Cited in: Theranostics. 2020 Jun 24;10(17):7906-7920.

    The expression of cell cycle-associated molecules is altered by Capsaicin treatment in both cell lines.The cell-cycle inhibitor p27Kip1 is upregulated after Capsaicin treatment while the G1-S phase transition marker cyclin D1 is downregulated. p38 phosphorylation levels are also decreased following capsaicin treatment.

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    Description

    Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin has pain relief, antioxidant, anti-inflammatory, neuroprotection and anti-cancer effects[1][2].

    IC50 & Target

    EC50: 290 nM (hTRPV1, in HEK293 cell)[1]

    In Vitro

    Capsaicin (50-300 µM; 24-72 hours) shows an augmented decrease in cell growth in a dose- and time-dependent manner. The observed IC50 value is around 150 µM[2].
    Capsaicin (50-300 µM; 24-72 hours) shows increase in cytosolic cytochrome c, activation of caspase 3 and PARP (p85) levels, and decreases anti-apoptotic Bcl-2 protein and increases pro-apoptotic Bad/Bax expression[2].
    Capsaicin increases the nuclear condensation, nuclear DNA fragmentation and sub-G1 DNA content[2].
    Capsaicin suppresses the cell cycle progression at the G1/S phase in FaDu cells by decreasing the expression of the regulators of cyclin B1 and D1, as well as cyclin-dependent protein kinases cdk-1, cdk-2 and cdk-4[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Viability Assay[2]

    Cell Line: Human pharyngeal squamous carcinoma cells (FaDu) cells
    Concentration: 50 µM, 100 µM, 200 µM, and 300 µM
    Incubation Time: 24 hours, 48 hours and 72 hours
    Result: Showed an augmented decrease in cell growth.

    Apoptosis Analysis[2]

    Cell Line: FaDu cells
    Concentration: 50 µM, 100 µM and 200 µM
    Incubation Time: 12 hours
    Result: Increased the activity of caspase 3 in a time-dependent manner.

    Western Blot Analysis[2]

    Cell Line: FaDu cells
    Concentration: 200 µM
    Incubation Time: 24 hours
    Result: The observed activation of caspase 3 and PARP (p85) levels.
    In Vivo

    Capsaicin suppresses the development of lung carcinoma by amending the protein expressions of apoptotic regulators p53, Bcl-2, Bax and caspase-3[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Swiss albino mice (20-25 g; 8-10 weeks old) induced by Benzo(a)pyrene[3]
    Dosage: 10 mg/kg
    Administration: Intraperitoneal administration; once in a week; for 14 weeks
    Result: Inhibited the development of mice lung carcinogenesis.
    Clinical Trial
    Molecular Weight

    305.41

    Formula

    C₁₈H₂₇NO₃

    CAS No.
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    Solvent & Solubility
    In Vitro: 

    Ethanol : 200 mg/mL (654.86 mM; Need ultrasonic)

    DMSO : 100 mg/mL (327.43 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.2743 mL 16.3714 mL 32.7429 mL
    5 mM 0.6549 mL 3.2743 mL 6.5486 mL
    10 mM 0.3274 mL 1.6371 mL 3.2743 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% EtOH    90% corn oil

      Solubility: ≥ 20 mg/mL (65.49 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (8.19 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (8.19 mM); Clear solution

    • 4.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (8.19 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 99.79%

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    Product Name:
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    Cat. No.:
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