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Isoforms Recommended:	TRPC

Results for "

TRPC6

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) Calcium Channel (2) ERK (2) Formyl Peptide Receptor (FPR) (1) HPV (1) p38 MAPK (1) Small Interfering RNA (siRNA) (1) Src (2) TRP Channel (22)
By Research Areas:	Cancer (2) Cardiovascular Disease (7) Infection (1) Inflammation/Immunology (2) Metabolic Disease (2) Neurological Disease (10)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-136190

TRPC6-PAM-C20	TRP Channel	Neurological Disease
TRPC6-PAM-C20 is a selective positive allosteric modulator (PAM) of *TRPC6* channels. TRPC6-PAM-C20 is a potent enhancer of channel activation, enabling low basal concentrations of DAG to induce activation of the ion channel. TRPC6-PAM-C20 induces increases in intracellular Ca ²⁺ concentrations ([Ca ²⁺]i) in TRPC6-expressing HEK293 cells with an EC₅₀ of 2.37 μM. TRPC6-PAM-C20 can be used as a valuable tool to selectively exaggerate TRPC6-dependent signals .

HY-148129

TRPC6-IN-3	TRP Channel	Cardiovascular Disease
TRPC6-IN-3 (compound 17) is a potent, orally active transient receptor potential C6 ion channel (TRPC6) inhibitor. TRPC6-IN-3 modulates not only intracellular calcium concentration, but also membrane potential by modulating the flux of cations including calcium and sodium ions. TRPC6-IN-3 can be used in research of respiratory system .

HY-101547

TRPC6-IN-1

1 Publications Verification

TRP Channel Cancer

TRPC6-IN-1 is a Transient Receptor Potential Canonical 6 Channel (TRPC6) inhibitor, with an EC₅₀ of 4.66 μM.

TRPC6-IN-1 1 Publications Verification	TRP Channel	Cancer
TRPC6-IN-1 is a Transient Receptor Potential Canonical 6 Channel *(TRPC6)* inhibitor, with an EC₅₀ of 4.66 μM.

HY-RS15109

TRPC6 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TRPC6 Human Pre-designed siRNA Set A contains three designed siRNAs for TRPC6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TRPC6 Human Pre-designed siRNA Set A TRPC6 Human Pre-designed siRNA Set A

HY-145151

TRPC6-IN-2

TRP Channel Others

The compound inhibits TRPC proteins, and more specifically inhibits the TRPC6 protein.

TRPC6-IN-2	TRP Channel	Others
The compound inhibits TRPC proteins, and more specifically inhibits the *TRPC6* protein.

HY-121519

GSK2332255B	TRP Channel	Cardiovascular Disease
GSK2332255B is a potent, selective *TRPC3* and *TRPC6* antagonist with IC₅₀s of 5 nM and 4 nM for rat *TRPC3* and rat *TRPC6. GSK2332255B shows ≥100-fold selectivity for TRPC*3/6 over other calcium-permeable channels .

HY-15699A

SAR7334 hydrochloride Maximum Cited Publications 15 Publications Verification	TRP Channel	Neurological Disease
SAR7334 hydrochloride is a potent and specific *TRPC6* inhibitor, inhibiting TRPC6 currents with IC₅₀ of 7.9 nM.

HY-15699

SAR7334 Maximum Cited Publications 15 Publications Verification	TRP Channel	Neurological Disease
SAR7334 is a potent and specific *TRPC6* inhibitor, inhibiting TRPC6 currents with IC₅₀ of 7.9 nM.

HY-111925

BI-749327 10+ Cited Publications	TRP Channel	Cardiovascular Disease
BI-749327 is a potent, high selectivity and orally bioavailable *TRPC6* antagonist, with IC₅₀s of 13 nM, 19 nM and 15 nM for mouse, human and guinea pig TRPC6, respectively. BI-749327 is 85-fold more selective for mouse TRPC6 than TRPC3 and 42-fold versus TRPC7 .

HY-112298

DS88790512

TRP Channel Cardiovascular Disease

DS88790512 is a potent, selective, and orally bioavailable TRPC6 inhibitor with an IC₅₀ of 11 nM.
HY-N10756

Hyp9

TRP Channel Neurological Disease

Hyp9 is a transient receptor potential canonical 6 (TRPC6)-specific agonist. Hyp9 can be used for the research of spinal cord injury (SCI) .
HY-153455

TRPC3/6-IN-2

TRP Channel Metabolic Disease

TRPC3/6-IN-2 is a potent TRPC3/6 inhibitor with IC₅₀ values of 16 nM and 29.8 nM for TRPC3 and TRPC6, respectively .

DS88790512	TRP Channel	Cardiovascular Disease
DS88790512 is a potent, selective, and orally bioavailable *TRPC6* inhibitor with an IC₅₀ of 11 nM.

Hyp9	TRP Channel	Neurological Disease
Hyp9 is a transient receptor potential canonical 6 (TRPC6)-specific agonist. Hyp9 can be used for the research of spinal cord injury (SCI) .

TRPC3/6-IN-2	TRP Channel	Metabolic Disease
TRPC3/6-IN-2 is a potent *TRPC3/6* inhibitor with IC₅₀ values of 16 nM and 29.8 nM for TRPC3 and TRPC6, respectively .

HY-116330

Hyperforin	Calcium Channel TRP Channel	Neurological Disease Inflammation/Immunology
Hyperforin is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin modulates Ca ²⁺ levels by activating Ca ²⁺-conducting non-selective canonical TRPC6 channels. Hyperforin also shows diverse pharmacological activities including anti-depression, anti-tumor, anti-dementia, anti-diabetes. Hyperforin modulates γδ T cells to secret IL-17α, improves Imiquimod (HY-B0180)-induced psoriasis-like mice model .

HY-116330A

Hyperforin dicyclohexylammonium salt 1 Publications Verification Hyperforin DCHA	TRP Channel Calcium Channel	Neurological Disease
Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin dicyclohexylammonium salt modulates Ca ²⁺ levels by activating Ca ²⁺-conducting non-selective canonical TRPC6 channels. Hyperforin dicyclohexylammonium salt also shows diverse pharmacological activities including anti-depression, anti-tumor, anti-dementia, anti-diabetes. Hyperforin dicyclohexylammonium salt modulates γδ T cells to secret IL-17α, improves Imiquimod (HY-B0180)-induced psoriasis-like mice model .

HY-12949

ML204 4 Publications Verification	TRP Channel	Neurological Disease
ML204 is a potent, selective *TRPC4/TRPC5* channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca ²⁺ channels .

HY-12949A

ML204 hydrochloride 4 Publications Verification	TRP Channel	Neurological Disease
ML204 hydrochloride is a novel, potent, selective *TRPC4/TRPC5* channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca ²⁺ channels .

HY-101795

Larixyl acetate 2 Publications Verification	TRP Channel HPV	Infection Neurological Disease
Larixyl acetate is a potent and selective *TRPC6* inhibitor with IC₅₀ values of 0.58 μM and 6.83 μM against *hTRPC6-YFP* and hTRPC3-YFP, respectively. Larixyl acetate prevents HPV and is effective in protecting against traumatic brain injury-induced systemic endothelial dysfunction .

HY-122051

AC1903 1 Publications Verification	TRP Channel	Metabolic Disease
AC1903 is a specific and selective inhibitor of *TRPC5* and has podocyte-protective properties. AC1903 does no effects on TRPC4 or TRPC6 currents and shows no off-target effects in kinase profiling assays. AC1903 suppresses severe proteinuria and prevents podocyte loss in focal segmental glomerulosclerosis (FSGS) rat model .

HY-101507

Pico145 5+ Cited Publications HC-608	TRP Channel	Cancer
Pico145 (HC-608) is a remarkable inhibitor of *TRPC1/4/5* channels, inhibits (−)-englerin A-activated TRPC4/TRPC5 channels, with IC₅₀s of 0.349 and 1.3 nM in cells, and shows no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, TRPM8 .

HY-133012

GFB-8438	TRP Channel	Neurological Disease
GFB-8438 is a potent and subtype selective *TRPC5* inhibitor, with IC₅₀s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively. GFB-8438 shows excellent selectivity against TRPC6, other TRP family members, NaV 1.5, as well as limited activity against the hERG channel. GFB-8438 protects mouse podocytes from injury induced by protamine sulfate model .

HY-W744699

Larixol (+)-Larixol	Src ERK Akt	Inflammation/Immunology
Larixol is an fMLP inhibitor and also inhibits Src kinase, ERK1/2, p38 and AKT phosphorylation signals in immune regulation. Larixol can interfere with the interaction between the βγ subunit of the fMLP receptor Gi protein and its downstream molecules, thereby inhibiting fMLP-induced respiratory burst. Larixol inhibits fMLP (0.1 μM)-induced superoxide anion production (IC₅₀: 1.98 μM), cathepsin G release (IC₅₀: 2.76 μM), and chemotaxis. Larixol improves neutrophil hyperactivation and reduces inflammation or tissue damage. A series of Larixol derivatives were found to have inhibitory effects on FSGS-related TRPC6 functional mutants .

HY-W745090

Isomaltulose monohydrate	Formyl Peptide Receptor (FPR) Src ERK Akt p38 MAPK	Others
Isomaltulose monohydrate is a fMLP inhibitor and also inhibits Src kinase, ERK1/2, p38 and AKT phosphorylation signals in immune regulation. Isomaltulose monohydrate can interfere with the interaction between the βγ subunit of the fMLP receptor Gi protein and its downstream molecules, thereby inhibiting fMLP-induced respiratory burst. Isomaltulose monohydrate inhibits fMLP (0.1 μM)-induced superoxide anion production (IC₅₀: 1.98 μM) , cathepsin G release (IC< sub>50: 2.76 μM) and chemotaxis. Isomaltulose monohydrate can improve excessive activation of neutrophils and reduce inflammation or tissue damage. A series of derivatives of Isomaltulose monohydrate are found to have inhibitory effects on FSGS-related TRPC6 functional mutants .

HY-120818

TRPC3/6-IN-3

TRP Channel Cardiovascular Disease

TRPC3/6-IN-3 is a selective TRPC3/6 blocker. TRPC3/6-IN-3 can be used for the research of cardiovascular disease .

TRPC3/6-IN-3	TRP Channel	Cardiovascular Disease
TRPC3/6-IN-3 is a selective *TRPC3/6* blocker. TRPC3/6-IN-3 can be used for the research of cardiovascular disease .

HY-111098

GSK1702934A 1 Publications Verification	TRP Channel	Cardiovascular Disease
GSK1702934A is a selective *TRPC3* agonist. GSK1702934A modulates cardiac contractility and f arrhythmogenesis by activation of TRPC3 .

HY-147357

TRPC3/6-IN-1	TRP Channel	Cardiovascular Disease
TRPC3/6-IN-1 is a potent selectivity blocker of the canonical transient receptor channels *(TRPC3/6), has block potency for hTRPC3 and hTRPC6 with IC₅₀* values of 1260 nM and 500 nM, respectively. TRPC3/6-IN-1 can be used for the research of chronic models of heart failure .

Isomaltulose monohydrate	Biochemical Assay Reagents
Isomaltulose monohydrate is a fMLP inhibitor and also inhibits Src kinase, ERK1/2, p38 and AKT phosphorylation signals in immune regulation. Isomaltulose monohydrate can interfere with the interaction between the βγ subunit of the fMLP receptor Gi protein and its downstream molecules, thereby inhibiting fMLP-induced respiratory burst. Isomaltulose monohydrate inhibits fMLP (0.1 μM)-induced superoxide anion production (IC₅₀: 1.98 μM) , cathepsin G release (IC< sub>50: 2.76 μM) and chemotaxis. Isomaltulose monohydrate can improve excessive activation of neutrophils and reduce inflammation or tissue damage. A series of derivatives of Isomaltulose monohydrate are found to have inhibitory effects on FSGS-related TRPC6 functional mutants .

Hyperforin dicyclohexylammonium salt 1 Publications Verification Hyperforin DCHA	Structural Classification Natural Products Source classification Guttiferae Hyperlcurn perforatum L. Plants	TRP Channel Calcium Channel
Hyperforin dicyclohexylammonium salt (Hyperforin DCHA) is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin dicyclohexylammonium salt modulates Ca ²⁺ levels by activating Ca ²⁺-conducting non-selective canonical TRPC6 channels. Hyperforin dicyclohexylammonium salt also shows diverse pharmacological activities including anti-depression, anti-tumor, anti-dementia, anti-diabetes. Hyperforin dicyclohexylammonium salt modulates γδ T cells to secret IL-17α, improves Imiquimod (HY-B0180)-induced psoriasis-like mice model .

Larixyl acetate 2 Publications Verification	Infection Structural Classification Natural Products Neurological Disease Classification of Application Fields Pinaceae Source classification Larch resin Plants Disease Research Fields	TRP Channel HPV
Larixyl acetate is a potent and selective *TRPC6* inhibitor with IC₅₀ values of 0.58 μM and 6.83 μM against *hTRPC6-YFP* and hTRPC3-YFP, respectively. Larixyl acetate prevents HPV and is effective in protecting against traumatic brain injury-induced systemic endothelial dysfunction .

Hyperforin	Structural Classification Anti-inflammation/Immunoregulatory Antibiotics Source classification Guttiferae Hyperlcurn perforatum L. Disease Research Plants Anticancer	Calcium Channel TRP Channel
Hyperforin is a transient receptor canonical 6 (TRPC6) channels activator. Hyperforin modulates Ca ²⁺ levels by activating Ca ²⁺-conducting non-selective canonical TRPC6 channels. Hyperforin also shows diverse pharmacological activities including anti-depression, anti-tumor, anti-dementia, anti-diabetes. Hyperforin modulates γδ T cells to secret IL-17α, improves Imiquimod (HY-B0180)-induced psoriasis-like mice model .

Larixol (+)-Larixol	Larix decidua Miller Structural Classification Natural Products Pinaceae Source classification Plants	Src ERK Akt
Larixol is an fMLP inhibitor and also inhibits Src kinase, ERK1/2, p38 and AKT phosphorylation signals in immune regulation. Larixol can interfere with the interaction between the βγ subunit of the fMLP receptor Gi protein and its downstream molecules, thereby inhibiting fMLP-induced respiratory burst. Larixol inhibits fMLP (0.1 μM)-induced superoxide anion production (IC₅₀: 1.98 μM), cathepsin G release (IC₅₀: 2.76 μM), and chemotaxis. Larixol improves neutrophil hyperactivation and reduces inflammation or tissue damage. A series of Larixol derivatives were found to have inhibitory effects on FSGS-related TRPC6 functional mutants .

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