1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. TRP Channel
  3. GSK1702934A

GSK1702934A 

Cat. No.: HY-111098 Purity: >99.0%
Handling Instructions

GSK1702934A is a selective TRPC3 agonist. GSK1702934A modulates cardiac contractility and f arrhythmogenesis by activation of TRPC3.

For research use only. We do not sell to patients.

GSK1702934A Chemical Structure

GSK1702934A Chemical Structure

CAS No. : 924377-85-5

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Description

GSK1702934A is a selective TRPC3 agonist. GSK1702934A modulates cardiac contractility and f arrhythmogenesis by activation of TRPC3[1][2].

IC50 & Target

TRPC3

 

In Vitro

GSK1702934A is able to induce TRPC3/6-currents in HEK293 cells transduced with recombinant human TRPC3/6 with an EC50 of 0.08 mM and 0.44 mM, respectively[1].
GSK1702934A induces a transient, non-selective conductance and prolonged action potentials in TRPC3-overexpressing myocytes but not in wild-type myocytes[2].
GSK1702934A substantially promotes NCX currents in TRPC3-overexpressing myocytes[2].

Molecular Weight

395.52

Formula

C₂₂H₂₅N₃O₂S

CAS No.

924377-85-5

SMILES

O=C1NC2=CC=CC=C2N1C3CCN(C(C4=CC(CCCCC5)=C5S4)=O)CC3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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Keywords:

GSK1702934ATRP ChannelTransient receptor potential channelsTRPC3TRPC6 cardiaccontractilityarrhythmogenesisInhibitorinhibitorinhibit

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GSK1702934A
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