1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. TRP Channel
  3. GSK1702934A

GSK1702934A 

Cat. No.: HY-111098 Purity: >99.0%
Handling Instructions

GSK1702934A is a selective TRPC3 agonist. GSK1702934A modulates cardiac contractility and f arrhythmogenesis by activation of TRPC3.

For research use only. We do not sell to patients.

GSK1702934A Chemical Structure

GSK1702934A Chemical Structure

CAS No. : 924377-85-5

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10 mM * 1 mL in DMSO USD 99 In-stock
Estimated Time of Arrival: December 31
5 mg USD 90 In-stock
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10 mg USD 160 In-stock
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50 mg USD 640 In-stock
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100 mg USD 1150 In-stock
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Description

GSK1702934A is a selective TRPC3 agonist. GSK1702934A modulates cardiac contractility and f arrhythmogenesis by activation of TRPC3[1][2].

IC50 & Target

TRPC3

 

In Vitro

GSK1702934A is able to induce TRPC3/6-currents in HEK293 cells transduced with recombinant human TRPC3/6 with an EC50 of 0.08 mM and 0.44 mM, respectively[1].
GSK1702934A induces a transient, non-selective conductance and prolonged action potentials in TRPC3-overexpressing myocytes but not in wild-type myocytes[2].
GSK1702934A substantially promotes NCX currents in TRPC3-overexpressing myocytes[2].

In Vivo

GSK1702934A (0.3-3 mg/kg; i.v.) transiently increases blood pressure by 15 ~ 35 mmHg in conscious Sprague Dawley rats[3].

Molecular Weight

395.52

Formula

C₂₂H₂₅N₃O₂S

CAS No.

924377-85-5

SMILES

O=C1NC2=CC=CC=C2N1C3CCN(C(C4=CC(CCCCC5)=C5S4)=O)CC3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (252.83 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5283 mL 12.6416 mL 25.2832 mL
5 mM 0.5057 mL 2.5283 mL 5.0566 mL
10 mM 0.2528 mL 1.2642 mL 2.5283 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.32 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.32 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.32 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: >99.0%

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Keywords:

GSK1702934ATRP ChannelTransient receptor potential channelsTRPC3TRPC6 cardiaccontractilityarrhythmogenesisInhibitorinhibitorinhibit

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Product Name:
GSK1702934A
Cat. No.:
HY-111098
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