1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. TRP Channel
  3. GSK2332255B

GSK2332255B 

Cat. No.: HY-121519
Handling Instructions

GSK2332255B is a potent, selective TRPC3 and TRPC6 antagonist with IC50s of 5 nM and 4 nM for rat TRPC3 and rat TRPC6. GSK2332255B shows ≥100-fold selectivity for TRPC3/6 over other calcium-permeable channels.

For research use only. We do not sell to patients.

GSK2332255B Chemical Structure

GSK2332255B Chemical Structure

CAS No. : 1366233-41-1

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Description

GSK2332255B is a potent, selective TRPC3 and TRPC6 antagonist with IC50s of 5 nM and 4 nM for rat TRPC3 and rat TRPC6. GSK2332255B shows ≥100-fold selectivity for TRPC3/6 over other calcium-permeable channels[1].

IC50 & Target[1]

rTRPC3

5 nM (IC50)

rTRPC6

4 nM (IC50)

In Vitro

Nuclear factor of activated T cells (NFAT) activation by Ang II ( angiotensin II) is blocked in a dose dependent manner by GSK255B (0.01, 0.1, and 1 μM) in HEK293T cells overexpressing TRPC3. GSK255B blocks NFAT activation by Ang II in HEK293T cells expressing a mutant TRPC6 channel with T70 and S322 mutated to glutamic acid (SETE)[1].
GSK255B (10 μM) blocks calcium entry stimulated by Phenylephrine (20 μM) in rat neonatal cardiac myocytes. GSK255B dose-dependent blockade of cell hypertrophy signaling triggered by angiotensin II or endothelin-1 in HEK293T cells as well as in neonatal and adult cardiac myocytes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

411.88

Formula

C₁₈H₁₉ClFN₃O₃S

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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GSK2332255B
Cat. No.:
HY-121519
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