1366233-41-1
1366233-41-1
Chemical Structure
GSK2332255B
- CAS No.: 1366233-41-1
- Formula:C18H19ClFN3O3S
- Molecular Weight:411.88
IUPAC Name: (5-chloro-2-((6-fluorobenzo[d][1,3]dioxol-5-yl)amino)thiazol-4-yl)(2,3-dimethylpiperidin-1-yl)methanone
InChIKey: GGKQWFQQUMWVOB-UHFFFAOYSA-N
SMILES: O=C(C1=C(Cl)SC(NC2=C(F)C=C(OCO3)C3=C2)=N1)N4C(C)C(C)CCC4
Biological Activity: GSK2332255B is a potent, selective TRPC3 and TRPC6 antagonist with IC50s of 5 nM and 4 nM for rat TRPC3 and rat TRPC6. GSK2332255B shows ≥100-fold selectivity for TRPC3/6 over other calcium-permeable channels[1].
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GSK2332255B | GSK2332255B is a potent, selective TRPC3 and TRPC6 antagonist with IC50s of 5 nM and 4 nM for rat TRPC3 and rat TRPC6. GSK2332255B shows ≥100-fold selectivity for TRPC3/6 over other calcium-permeable channels. | |||||||||||||||||||||
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References
Keywords
